FI961621A - Proteiini:farnesyylitranseraasin substituoidut tetra- ja pentapeptidi-inhibiittorit - Google Patents

Proteiini:farnesyylitranseraasin substituoidut tetra- ja pentapeptidi-inhibiittorit Download PDF

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Publication number
FI961621A
FI961621A FI961621A FI961621A FI961621A FI 961621 A FI961621 A FI 961621A FI 961621 A FI961621 A FI 961621A FI 961621 A FI961621 A FI 961621A FI 961621 A FI961621 A FI 961621A
Authority
FI
Finland
Prior art keywords
protein
farnesyl transferase
inhibitors
substituted tetra
pentapeptide inhibitors
Prior art date
Application number
FI961621A
Other languages
English (en)
Swedish (sv)
Other versions
FI961621A0 (fi
Inventor
Gary Louis Bolton
Alfred Campbell
Richard Gowan
John Cooke Hodges
Donald Hupe
Daniele Leonard
Tomi Sawyer
Judith Sebolt-Leopold
Francis J Tinney
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Publication of FI961621A publication Critical patent/FI961621A/fi
Publication of FI961621A0 publication Critical patent/FI961621A0/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI961621A 1993-10-25 1996-04-12 Proteiini:farnesyylitranseraasin substituoidut tetra- ja pentapeptidi-inhibiittorit FI961621A0 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14275693A 1993-10-25 1993-10-25
US30963594A 1994-09-23 1994-09-23
PCT/US1994/012060 WO1995011917A1 (en) 1993-10-25 1994-10-21 Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase

Publications (2)

Publication Number Publication Date
FI961621A true FI961621A (fi) 1996-04-12
FI961621A0 FI961621A0 (fi) 1996-04-12

Family

ID=26840404

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961621A FI961621A0 (fi) 1993-10-25 1996-04-12 Proteiini:farnesyylitranseraasin substituoidut tetra- ja pentapeptidi-inhibiittorit

Country Status (15)

Country Link
EP (1) EP0725790B1 (fi)
JP (1) JPH09504295A (fi)
KR (1) KR100378615B1 (fi)
AT (1) ATE200677T1 (fi)
AU (1) AU682906B2 (fi)
CA (1) CA2173590A1 (fi)
DE (1) DE69427127T2 (fi)
DK (1) DK0725790T3 (fi)
ES (1) ES2157994T3 (fi)
FI (1) FI961621A0 (fi)
GR (1) GR3036188T3 (fi)
LV (1) LV12771B (fi)
NZ (1) NZ275037A (fi)
PT (1) PT725790E (fi)
WO (1) WO1995011917A1 (fi)

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US5856326A (en) * 1995-03-29 1999-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
DE69427127T2 (de) 2001-10-04
DK0725790T3 (da) 2001-06-11
EP0725790B1 (en) 2001-04-18
AU8051394A (en) 1995-05-22
JPH09504295A (ja) 1997-04-28
AU682906B2 (en) 1997-10-23
GR3036188T3 (en) 2001-10-31
CA2173590A1 (en) 1995-05-04
PT725790E (pt) 2001-08-30
NZ275037A (en) 1998-01-26
ES2157994T3 (es) 2001-09-01
WO1995011917A1 (en) 1995-05-04
KR100378615B1 (ko) 2003-10-10
ATE200677T1 (de) 2001-05-15
LV12771A (lv) 2001-12-20
DE69427127D1 (de) 2001-05-23
LV12771B (en) 2002-03-20
FI961621A0 (fi) 1996-04-12
EP0725790A1 (en) 1996-08-14

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