IT1273986B - Inibitori peptidici di farnesil proteina transferasi - Google Patents
Inibitori peptidici di farnesil proteina transferasiInfo
- Publication number
- IT1273986B IT1273986B ITRM940620A ITRM940620A IT1273986B IT 1273986 B IT1273986 B IT 1273986B IT RM940620 A ITRM940620 A IT RM940620A IT RM940620 A ITRM940620 A IT RM940620A IT 1273986 B IT1273986 B IT 1273986B
- Authority
- IT
- Italy
- Prior art keywords
- protein transferase
- inhibitors
- farnesil
- peptidal
- peptidal inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
La presente invenzione è diretta a tetrapeptidi che inibiscono farnesil proteina trasferasi (FPT) ed alla farnesilazione della proteina oncogena Ras. L'invenzione è diretta ancora ad un metodo per trattare cancro con inibitori tetrapeptidici di farnesil proteina trasferasi, nonché a formulazioni farmaceutiche utili per questo metodo di trattamento.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM940620A IT1273986B (it) | 1994-09-28 | 1994-09-28 | Inibitori peptidici di farnesil proteina transferasi |
US08/459,885 US5661128A (en) | 1994-09-28 | 1995-06-02 | Peptide inhibitors of farnesyl-protein transferase |
AU25746/95A AU2574695A (en) | 1994-09-28 | 1995-06-05 | Peptide inhibitors of farnesyl-protein transferase |
PCT/IT1995/000093 WO1996010037A1 (en) | 1994-09-28 | 1995-06-05 | Peptide inhibitors of farnesyl-protein transferase |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM940620A IT1273986B (it) | 1994-09-28 | 1994-09-28 | Inibitori peptidici di farnesil proteina transferasi |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM940620A0 ITRM940620A0 (it) | 1994-09-28 |
ITRM940620A1 ITRM940620A1 (it) | 1996-03-28 |
IT1273986B true IT1273986B (it) | 1997-07-14 |
Family
ID=11402744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM940620A IT1273986B (it) | 1994-09-28 | 1994-09-28 | Inibitori peptidici di farnesil proteina transferasi |
Country Status (4)
Country | Link |
---|---|
US (1) | US5661128A (it) |
AU (1) | AU2574695A (it) |
IT (1) | IT1273986B (it) |
WO (1) | WO1996010037A1 (it) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2718149B1 (fr) * | 1994-03-30 | 1996-04-26 | Rhone Poulenc Rorer Sa | Nouveaux peptides manifestant des propriétés inhibitrices de farnesyl transférase et microorganisme du genre streptomyces susceptible d'être utilisé pour les préparer. |
IT1273986B (it) * | 1994-09-28 | 1997-07-14 | Merck & Co Inc | Inibitori peptidici di farnesil proteina transferasi |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
US5043268A (en) * | 1990-05-04 | 1991-08-27 | The Trustees Of Princeton University | Substrates and inhibitors for prenyl cysteine methyltransferase enzymes |
US5185248A (en) * | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
CA2072033A1 (en) * | 1991-06-28 | 1992-12-29 | Jackson B. Gibbs | Non-substrate inhibitors of farnesyl protein transferase |
EP0528486A2 (en) * | 1991-08-16 | 1993-02-24 | Merck & Co. Inc. | Non-substrate inhibitors of farnesyl protein transferase |
US5238922A (en) * | 1991-09-30 | 1993-08-24 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US5340828A (en) * | 1991-09-30 | 1994-08-23 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US5352705A (en) * | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US5504212A (en) * | 1992-10-29 | 1996-04-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5326773A (en) * | 1992-10-29 | 1994-07-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5686472A (en) * | 1992-10-29 | 1997-11-11 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2118985A1 (en) * | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Heterocyclic inhibitors of farnesyl protein transferase |
DE69427127T2 (de) * | 1993-10-25 | 2001-10-04 | Parke Davis & Co | Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase |
IT1273986B (it) * | 1994-09-28 | 1997-07-14 | Merck & Co Inc | Inibitori peptidici di farnesil proteina transferasi |
-
1994
- 1994-09-28 IT ITRM940620A patent/IT1273986B/it active IP Right Grant
-
1995
- 1995-06-02 US US08/459,885 patent/US5661128A/en not_active Expired - Fee Related
- 1995-06-05 WO PCT/IT1995/000093 patent/WO1996010037A1/en active Application Filing
- 1995-06-05 AU AU25746/95A patent/AU2574695A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2574695A (en) | 1996-04-19 |
WO1996010037A1 (en) | 1996-04-04 |
US5661128A (en) | 1997-08-26 |
ITRM940620A1 (it) | 1996-03-28 |
ITRM940620A0 (it) | 1994-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |