ATE240313T1 - Tricyclische n-cyanoimine als inhibitoren der farnesyl-protein transferase - Google Patents
Tricyclische n-cyanoimine als inhibitoren der farnesyl-protein transferaseInfo
- Publication number
- ATE240313T1 ATE240313T1 AT97934269T AT97934269T ATE240313T1 AT E240313 T1 ATE240313 T1 AT E240313T1 AT 97934269 T AT97934269 T AT 97934269T AT 97934269 T AT97934269 T AT 97934269T AT E240313 T1 ATE240313 T1 AT E240313T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanoimine
- farnesyl
- inhibitors
- tricyclic
- protein transferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69052296A | 1996-07-31 | 1996-07-31 | |
| PCT/US1997/012923 WO1998004545A1 (en) | 1996-07-31 | 1997-07-29 | Novel tricyclic n-cyanoimines useful as inhibitors of farnesyl-protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240313T1 true ATE240313T1 (de) | 2003-05-15 |
Family
ID=24772812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97934269T ATE240313T1 (de) | 1996-07-31 | 1997-07-29 | Tricyclische n-cyanoimine als inhibitoren der farnesyl-protein transferase |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0915869B1 (de) |
| JP (1) | JP3153555B2 (de) |
| CN (1) | CN1117745C (de) |
| AT (1) | ATE240313T1 (de) |
| AU (1) | AU3737097A (de) |
| CA (1) | CA2261724C (de) |
| CO (1) | CO4900031A1 (de) |
| DE (1) | DE69722002T2 (de) |
| ES (1) | ES2194207T3 (de) |
| ID (1) | ID19401A (de) |
| PE (1) | PE92098A1 (de) |
| WO (1) | WO1998004545A1 (de) |
| ZA (1) | ZA976754B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002533336A (ja) * | 1998-12-18 | 2002-10-08 | シェーリング コーポレイション | 三環式ファルネシルタンパク質トランスフェラーゼインヒビター |
| AR033680A1 (es) * | 2000-08-30 | 2004-01-07 | Schering Corp | Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales |
| CN102731476A (zh) * | 2012-05-29 | 2012-10-17 | 安徽宏业药业有限公司 | 含氰胍结构的苯并环庚基吡啶衍生物、制备方法、药物组合物及其医药用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| CA1341044C (en) * | 1988-04-28 | 2000-07-04 | Frank J. Villani | Benzopyrido piperidine, piperidylidene and peperazine compounds, compositions, methods of manufacture and methods of use |
| TW308594B (de) * | 1993-10-15 | 1997-06-21 | Schering Corp | |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
-
1997
- 1997-07-22 PE PE1997000654A patent/PE92098A1/es not_active Application Discontinuation
- 1997-07-29 EP EP97934269A patent/EP0915869B1/de not_active Expired - Lifetime
- 1997-07-29 DE DE69722002T patent/DE69722002T2/de not_active Expired - Fee Related
- 1997-07-29 ZA ZA9706754A patent/ZA976754B/xx unknown
- 1997-07-29 JP JP50895298A patent/JP3153555B2/ja not_active Expired - Fee Related
- 1997-07-29 CA CA002261724A patent/CA2261724C/en not_active Expired - Fee Related
- 1997-07-29 AU AU37370/97A patent/AU3737097A/en not_active Abandoned
- 1997-07-29 CO CO97043296A patent/CO4900031A1/es unknown
- 1997-07-29 CN CN97196817A patent/CN1117745C/zh not_active Expired - Fee Related
- 1997-07-29 WO PCT/US1997/012923 patent/WO1998004545A1/en active IP Right Grant
- 1997-07-29 ES ES97934269T patent/ES2194207T3/es not_active Expired - Lifetime
- 1997-07-29 ID IDP972631A patent/ID19401A/id unknown
- 1997-07-29 AT AT97934269T patent/ATE240313T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69722002D1 (de) | 2003-06-18 |
| CA2261724A1 (en) | 1998-02-05 |
| DE69722002T2 (de) | 2004-04-01 |
| CO4900031A1 (es) | 2000-03-27 |
| EP0915869B1 (de) | 2003-05-14 |
| WO1998004545A1 (en) | 1998-02-05 |
| CA2261724C (en) | 2003-05-13 |
| ES2194207T3 (es) | 2003-11-16 |
| JP2000500783A (ja) | 2000-01-25 |
| ID19401A (id) | 1998-07-09 |
| AU3737097A (en) | 1998-02-20 |
| CN1117745C (zh) | 2003-08-13 |
| CN1226246A (zh) | 1999-08-18 |
| EP0915869A1 (de) | 1999-05-19 |
| ZA976754B (en) | 1998-02-02 |
| PE92098A1 (es) | 1998-12-31 |
| JP3153555B2 (ja) | 2001-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2293706A1 (en) | N-substituted urea inhibitors of farnesyl-protein transferase | |
| DE69628556D1 (de) | Tricyclische verbindungen als inhibitoren von farnesyl protein transferase | |
| MX9707732A (es) | Compuestos triciclicos utiles en el tratamiento de desordenes proliferativos de celulas. | |
| DE69628559D1 (en) | Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase | |
| MX9707665A (es) | Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas. | |
| MY110104A (en) | Saccharin derivative proteolytic enzyme inhibitors | |
| AU2443184A (en) | Benzazocinones and benzazoninones | |
| ATE252885T1 (de) | Plan zur verabreichung von h+, k+-atpase inhibitoren | |
| MY143570A (en) | Compounds useful for inhibition of farnesyl protein transferase | |
| TR199901274T2 (xx) | Farnezil protein transferaz inhibit�rleri olarak yararl� yeni trisiklik piperidinil bile�ikleri | |
| DE69926078D1 (en) | Farnesyl-protein transferase inhibitoren | |
| CA2293358A1 (en) | Tricyclic sulfonamide inhibitors of farnesyl-protein transferase | |
| ATE240313T1 (de) | Tricyclische n-cyanoimine als inhibitoren der farnesyl-protein transferase | |
| ATE236149T1 (de) | Tricyclische aminooxyamide derivate als farnesyl protein transferase inhibitoren | |
| CA2293549A1 (en) | Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase | |
| CA2293713A1 (en) | Bispyrido-cycloheptane compounds useful for inhibition of farnesyl protein transferase | |
| IL89537A (en) | Di- and tripeptides having inhibitory action on the enzymatic system, their preparation and pharmaceutical compositions containing them | |
| ECSP982531A (es) | Novedosos inhibidores de urea - n - sustituida de transferasa de proteina, farnesilo (case in0728) | |
| ECSP982536A (es) | Compuestos utiles para la inhibicion de transferasa de proteina al farnesilo ( case ino750k) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |