RS50352B - Monosupstituisane 3-propil gama-aminobuterne kiseline - Google Patents

Monosupstituisane 3-propil gama-aminobuterne kiseline

Info

Publication number
RS50352B
RS50352B YUP-870/01A YUP87001A RS50352B RS 50352 B RS50352 B RS 50352B YU P87001 A YUP87001 A YU P87001A RS 50352 B RS50352 B RS 50352B
Authority
RS
Serbia
Prior art keywords
monosubstituted
aminobutyric acids
propyl gamma
gamma
propyl
Prior art date
Application number
YUP-870/01A
Other languages
English (en)
Inventor
Thomas Richard Belliotti
Justin Stephen Bryans
Ihoezo Victor Ekhato
Augustine Tobi Osuma
Robert Michael Schelkun
Jacob Bradley Schwarz
Andrew John Thorpe
Lawrence David Wise
David Juergen Wustrow
Po-Wai Yuen
Original Assignee
Warner-Lambert Company Llc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company Llc., filed Critical Warner-Lambert Company Llc.,
Publication of YU87001A publication Critical patent/YU87001A/sh
Publication of RS50352B publication Critical patent/RS50352B/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/10Antiepileptics; Anticonvulsants for petit-mal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Jedinjenje (3S,5R)-3-aminometil-5-metil-oktanska kiselina ili njena farmaceutski prihvatljiva so. Prijava sadrži još 2 patentna zahteva.
YUP-870/01A 1999-06-10 2000-05-31 Monosupstituisane 3-propil gama-aminobuterne kiseline RS50352B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13848599P 1999-06-10 1999-06-10

Publications (2)

Publication Number Publication Date
YU87001A YU87001A (sh) 2004-07-15
RS50352B true RS50352B (sr) 2009-11-10

Family

ID=22482232

Family Applications (2)

Application Number Title Priority Date Filing Date
YUP-870/01A RS50352B (sr) 1999-06-10 2000-05-31 Monosupstituisane 3-propil gama-aminobuterne kiseline
RSP-2009/0257A RS20090257A (en) 1999-06-10 2000-05-31 Mono- and disubstituted 3-propyl gamma aminobutyric acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
RSP-2009/0257A RS20090257A (en) 1999-06-10 2000-05-31 Mono- and disubstituted 3-propyl gamma aminobutyric acids

Country Status (43)

Country Link
EP (1) EP1192125B9 (sr)
JP (1) JP3904452B2 (sr)
KR (1) KR100694735B1 (sr)
CN (2) CN1196671C (sr)
AP (1) AP1397A (sr)
AR (1) AR033335A1 (sr)
AT (1) ATE419231T1 (sr)
AU (1) AU776723C (sr)
BG (1) BG65561B1 (sr)
BR (1) BR0011727A (sr)
CA (2) CA2374755C (sr)
CO (1) CO5200791A1 (sr)
CR (1) CR6529A (sr)
CU (1) CU23101A3 (sr)
CY (1) CY1108827T1 (sr)
CZ (2) CZ300834B6 (sr)
DE (1) DE60041256D1 (sr)
DK (1) DK1192125T3 (sr)
DZ (1) DZ3253A1 (sr)
EA (1) EA004398B1 (sr)
EE (1) EE200100672A (sr)
ES (1) ES2317839T3 (sr)
GE (1) GEP20074142B (sr)
HK (1) HK1046401B (sr)
HR (1) HRP20020025A2 (sr)
HU (1) HUP0201601A3 (sr)
IL (2) IL146969A0 (sr)
IS (1) IS6181A (sr)
MA (1) MA26804A1 (sr)
ME (1) MEP44808A (sr)
MX (1) MXPA01012319A (sr)
NO (2) NO327746B1 (sr)
NZ (1) NZ515668A (sr)
OA (1) OA11962A (sr)
PE (1) PE20010285A1 (sr)
PT (1) PT1192125E (sr)
RS (2) RS50352B (sr)
SI (1) SI1192125T1 (sr)
SK (2) SK287247B6 (sr)
TR (1) TR200103587T2 (sr)
UA (1) UA72519C2 (sr)
WO (1) WO2000076958A2 (sr)
ZA (1) ZA200109711B (sr)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US6620829B2 (en) 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CN1533270A (zh) * 2001-06-11 2004-09-29 ʲŵ�������޹�˾ 具有降低毒性的gaba类似物前药的口服给药剂型
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
JP2005521664A (ja) * 2002-01-31 2005-07-21 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 耳鳴を治療するためのアルファ2デルタ・リガンド
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
US20030225149A1 (en) * 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
US7071339B2 (en) 2002-08-29 2006-07-04 Warner Lambert Company Llc Process for preparing functionalized γ-butyrolactones from mucohalic acid
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
EP1572188A1 (en) 2002-12-13 2005-09-14 Warner-Lambert Company LLC Pregabalin derivatives for the treatment of fibromyalgia and other disorders
PL377662A1 (pl) * 2002-12-13 2006-02-06 Warner-Lambert Company Llc Pregabalina i jej pochodne w leczeniu fibromialgii i innych zaburzeń pokrewnych
WO2004054560A1 (en) 2002-12-13 2004-07-01 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
CA2572324A1 (en) * 2003-07-02 2005-01-13 Warner-Lambert Company Llc Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
KR100828218B1 (ko) 2003-09-12 2008-05-07 화이자 인코포레이티드 알파-2-델타 리간드 및 세로토닌/노르아드레날린 재흡수 억제제를 포함하는 조합물
AP2006003544A0 (en) * 2003-09-25 2006-04-30 Warner Lambert Co Amino acids with affinity for the alpha2delta-protein.
MXPA06003396A (es) 2003-09-25 2006-06-08 Warner Lambert Co Profarmacos de aminoacidos con afinidad por la proteina a 2d.
WO2006043171A2 (en) * 2004-10-23 2006-04-27 Warner-Lambert Company Llc Methods of using alpha2delta-1 selective compounds
NZ566240A (en) * 2005-09-15 2011-05-27 Ucb Pharma Sa 4-substituted pyrrolidin-2-ones and their use
US20070141684A1 (en) 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
ATE511860T1 (de) 2006-12-22 2011-06-15 Recordati Ireland Ltd Kombinationstherapie für erkrankungen der unteren harnwege mit 2 liganden und nsar
WO2009136375A1 (en) * 2008-05-08 2009-11-12 Pfizer Inc Treatment of interstitial cystitis
CA2783699C (en) 2009-12-08 2019-01-15 Case Western Reserve University Primary amine compounds for treating ocular disorders
CN101914031B (zh) * 2010-07-30 2013-08-28 中国广州分析测试中心 普瑞巴林衍生物及其应用
SI3364958T1 (sl) * 2015-10-23 2023-05-31 Navitor Pharmaceuticals, Inc. Modulatorji interakcije sestrina in gator2 ter njihova uporaba
CA3061611A1 (en) 2017-04-26 2018-11-01 Navitor Pharmaceuticals, Inc. Modulators of sestrin-gator2 interaction and uses thereof
AU2019364542B2 (en) 2018-10-24 2025-08-28 Navitor Pharmaceuticals, Inc. Polymorphic compounds and uses thereof

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DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
WO1992009560A1 (en) * 1990-11-27 1992-06-11 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
WO1993023383A1 (en) * 1992-05-20 1993-11-25 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
SI0934061T1 (en) * 1996-07-24 2003-10-31 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
NZ334898A (en) * 1996-10-23 2000-09-29 Warner Lambert Co Substituted gamma aminobutyric acids as pharamceutical agents
CU23048A3 (es) * 1997-10-27 2005-06-24 Warner Lambert Co Aminoacidos ciclicos y derivados de los mismos, utiles como agentes farmaceuticos

Also Published As

Publication number Publication date
EP1192125B1 (en) 2008-12-31
CN1310872C (zh) 2007-04-18
CZ301608B6 (cs) 2010-04-28
HK1046401B (zh) 2005-12-02
NO20015949L (no) 2001-12-05
NZ515668A (en) 2004-02-27
KR20020009631A (ko) 2002-02-01
CN1355784A (zh) 2002-06-26
DE60041256D1 (de) 2009-02-12
AP1397A (en) 2005-04-19
NO20091094L (no) 2001-12-05
CA2374755C (en) 2010-03-30
CO5200791A1 (es) 2002-09-27
EA200101134A1 (ru) 2002-06-27
AP2002002388A0 (en) 2002-03-31
EE200100672A (et) 2003-02-17
SI1192125T1 (sl) 2009-04-30
RS20090257A (en) 2010-03-02
SK287399B6 (sk) 2010-08-09
HUP0201601A3 (en) 2002-11-28
IS6181A (is) 2001-11-28
SK17642001A3 (sk) 2002-10-08
JP2003502308A (ja) 2003-01-21
EP1192125B9 (en) 2009-09-16
HUP0201601A2 (en) 2002-10-28
AR033335A1 (es) 2003-12-17
BG65561B1 (bg) 2008-12-30
CN1196671C (zh) 2005-04-13
DZ3253A1 (fr) 2000-12-21
ES2317839T3 (es) 2009-05-01
WO2000076958A2 (en) 2000-12-21
UA72519C2 (en) 2005-03-15
MA26804A1 (fr) 2004-12-20
OA11962A (en) 2006-04-17
EA004398B1 (ru) 2004-04-29
CR6529A (es) 2003-11-25
KR100694735B1 (ko) 2007-03-14
DK1192125T3 (da) 2009-02-16
CZ300834B6 (cs) 2009-08-19
ZA200109711B (en) 2003-03-20
HK1046401A1 (en) 2003-01-10
GEP20074142B (en) 2007-07-10
MEP44808A (en) 2011-02-10
IL146969A0 (en) 2002-08-14
ATE419231T1 (de) 2009-01-15
CZ20014285A3 (cs) 2002-07-17
CY1108827T1 (el) 2014-04-09
JP3904452B2 (ja) 2007-04-11
PL352431A1 (en) 2003-08-25
SK287247B6 (sk) 2010-04-07
EP1192125A2 (en) 2002-04-03
CA2374755A1 (en) 2000-12-21
MXPA01012319A (es) 2002-07-22
CA2689997A1 (en) 2000-12-21
BG106292A (bg) 2002-05-31
AU5311900A (en) 2001-01-02
HK1076626A1 (en) 2006-01-20
WO2000076958A3 (en) 2001-04-12
IL146969A (en) 2008-03-20
BR0011727A (pt) 2002-03-05
CN1660779A (zh) 2005-08-31
AU776723C (en) 2005-06-02
PE20010285A1 (es) 2001-03-22
PT1192125E (pt) 2009-03-05
NO20015949D0 (no) 2001-12-05
TR200103587T2 (tr) 2002-04-22
CU23101A3 (es) 2005-12-20
NO327746B1 (no) 2009-09-14
AU776723B2 (en) 2004-09-16
YU87001A (sh) 2004-07-15
HRP20020025A2 (en) 2003-12-31

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