BG106292A - Моно- и дизаместени 3-пропил гама - аминомаслени киселини - Google Patents

Моно- и дизаместени 3-пропил гама - аминомаслени киселини

Info

Publication number
BG106292A
BG106292A BG106292A BG10629202A BG106292A BG 106292 A BG106292 A BG 106292A BG 106292 A BG106292 A BG 106292A BG 10629202 A BG10629202 A BG 10629202A BG 106292 A BG106292 A BG 106292A
Authority
BG
Bulgaria
Prior art keywords
disubstituted
disorders
mono
aminobutyric acids
propyl gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
BG106292A
Other languages
English (en)
Other versions
BG65561B1 (bg
Inventor
Thomas Belliotti
Justin Bryans
Ihoezo EKHATO
Augustine OSUMA
Robert SCHELKUN
Roy SCHWARZ
Andrew Thorpe
Lawrence WISE
David Wustrow
Po-Wai Yuen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner-Lambert Co
Original Assignee
Warner-Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Co filed Critical Warner-Lambert Co
Publication of BG106292A publication Critical patent/BG106292A/bg
Publication of BG65561B1 publication Critical patent/BG65561B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/10Antiepileptics; Anticonvulsants for petit-mal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до серия нови моно- и дизаместени 3-пропил гама-аминомаслени киселини с формула. Съединенията са полезни като лекарствени средства при лечение на епилепсия, прилошаване, хипокинезия, черепни нарушения, невродегенеративни нарушения, депресия, страх, паника, болка, невропатологични нарушения, артрит, нарушения в съня, дразнещчревен синдром и стомашни увреждания. Изобретението се отнася и до методи за получаване на съединенията и техните междинни съединения.
BG106292A 1999-06-10 2002-01-09 Моно- и дизаместени 3-пропил гама-аминомаслени киселини, фармацевтичен състав и използването им BG65561B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13848599P 1999-06-10 1999-06-10

Publications (2)

Publication Number Publication Date
BG106292A true BG106292A (bg) 2002-05-31
BG65561B1 BG65561B1 (bg) 2008-12-30

Family

ID=22482232

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106292A BG65561B1 (bg) 1999-06-10 2002-01-09 Моно- и дизаместени 3-пропил гама-аминомаслени киселини, фармацевтичен състав и използването им

Country Status (43)

Country Link
EP (1) EP1192125B9 (bg)
JP (1) JP3904452B2 (bg)
KR (1) KR100694735B1 (bg)
CN (2) CN1196671C (bg)
AP (1) AP1397A (bg)
AR (1) AR033335A1 (bg)
AT (1) ATE419231T1 (bg)
AU (1) AU776723C (bg)
BG (1) BG65561B1 (bg)
BR (1) BR0011727A (bg)
CA (2) CA2689997A1 (bg)
CO (1) CO5200791A1 (bg)
CR (1) CR6529A (bg)
CU (1) CU23101A3 (bg)
CY (1) CY1108827T1 (bg)
CZ (2) CZ300834B6 (bg)
DE (1) DE60041256D1 (bg)
DK (1) DK1192125T3 (bg)
DZ (1) DZ3253A1 (bg)
EA (1) EA004398B1 (bg)
EE (1) EE200100672A (bg)
ES (1) ES2317839T3 (bg)
GE (1) GEP20074142B (bg)
HK (2) HK1046401B (bg)
HR (1) HRP20020025A2 (bg)
HU (1) HUP0201601A3 (bg)
IL (2) IL146969A0 (bg)
IS (1) IS6181A (bg)
MA (1) MA26804A1 (bg)
ME (1) MEP44808A (bg)
MX (1) MXPA01012319A (bg)
NO (2) NO327746B1 (bg)
NZ (1) NZ515668A (bg)
OA (1) OA11962A (bg)
PE (1) PE20010285A1 (bg)
PT (1) PT1192125E (bg)
RS (2) RS20090257A (bg)
SI (1) SI1192125T1 (bg)
SK (2) SK287399B6 (bg)
TR (1) TR200103587T2 (bg)
UA (1) UA72519C2 (bg)
WO (1) WO2000076958A2 (bg)
ZA (1) ZA200109711B (bg)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US6620829B2 (en) 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
ES2296956T5 (es) * 2001-06-11 2011-07-12 Xenoport, Inc. Profármacos de análogos de gaba, composiciones y sus usos.
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
KR20040081478A (ko) 2002-01-31 2004-09-21 워너-램버트 캄파니 엘엘씨 이명을 치료하기 위한 알파 2 델타 리간드
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
US20030225149A1 (en) * 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
US7071339B2 (en) 2002-08-29 2006-07-04 Warner Lambert Company Llc Process for preparing functionalized γ-butyrolactones from mucohalic acid
KR100845932B1 (ko) * 2002-12-13 2008-07-11 워너-램버트 캄파니 엘엘씨 섬유근육통 및 기타 관련 질환의 치료를 위한 프레가발린및 그의 유도체
KR20050085563A (ko) 2002-12-13 2005-08-29 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드
JP2006513257A (ja) 2002-12-13 2006-04-20 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 線維筋痛症および他の障害を処置するためのプレガバリン誘導体
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
WO2005002585A1 (en) * 2003-07-02 2005-01-13 Warner-Lambert Company Llc Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
BRPI0414343A (pt) 2003-09-12 2006-11-07 Pfizer combinações que compreendem ligantes de alfa-2-delta e inibidores da reabsorção de serotonina/noradrenalina
BRPI0414819A (pt) 2003-09-25 2006-11-14 Warner Lambert Co pró-fármacos de aminoácidos com afinidade para a proteìna alfa2delta
OA13258A (en) * 2003-09-25 2007-01-31 Warner Lambert Co Amino acids with affinity for the alpha2delta-protein.
WO2006043171A2 (en) * 2004-10-23 2006-04-27 Warner-Lambert Company Llc Methods of using alpha2delta-1 selective compounds
US8957226B2 (en) * 2005-09-15 2015-02-17 Ucb Pharma S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US20070141684A1 (en) * 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
WO2008077599A1 (en) 2006-12-22 2008-07-03 Recordati Ireland Limited COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH α2δ LIGANDS AND NSAIDS
WO2009136375A1 (en) * 2008-05-08 2009-11-12 Pfizer Inc Treatment of interstitial cystitis
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
CN101914031B (zh) * 2010-07-30 2013-08-28 中国广州分析测试中心 普瑞巴林衍生物及其应用
MX2018004674A (es) * 2015-10-23 2018-09-11 Navitor Pharm Inc Moduladores de interacción de sestrina-gator2 y sus usos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
AU9137091A (en) * 1990-11-27 1992-06-25 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
RU94046105A (ru) * 1992-05-20 1997-06-20 Нортвестерн Юниверсити (Us) АНАЛОГИ γ -АМИНОМАСЛЯНОЙ КИСЛОТЫ И L-ГЛУТАМИНОВОЙ КИСЛОТЫ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
BR9710536A (pt) * 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
US6153650A (en) * 1996-10-23 2000-11-28 Warner-Lambert Company Substituted gamma aminobutyric acids as pharmaceutical agents
CN1303059C (zh) * 1997-10-27 2007-03-07 沃尼尔·朗伯公司 作为药物的环状氨基酸及其衍生物

Also Published As

Publication number Publication date
PL352431A1 (en) 2003-08-25
SK287247B6 (sk) 2010-04-07
CU23101A3 (es) 2005-12-20
SI1192125T1 (sl) 2009-04-30
CN1196671C (zh) 2005-04-13
YU87001A (sh) 2004-07-15
TR200103587T2 (tr) 2002-04-22
KR20020009631A (ko) 2002-02-01
DK1192125T3 (da) 2009-02-16
EP1192125B1 (en) 2008-12-31
DZ3253A1 (fr) 2000-12-21
AR033335A1 (es) 2003-12-17
EA004398B1 (ru) 2004-04-29
GEP20074142B (en) 2007-07-10
PT1192125E (pt) 2009-03-05
WO2000076958A3 (en) 2001-04-12
MEP44808A (en) 2011-02-10
EP1192125B9 (en) 2009-09-16
NZ515668A (en) 2004-02-27
WO2000076958A2 (en) 2000-12-21
OA11962A (en) 2006-04-17
RS20090257A (en) 2010-03-02
CA2374755A1 (en) 2000-12-21
HK1046401B (zh) 2005-12-02
CO5200791A1 (es) 2002-09-27
MXPA01012319A (es) 2002-07-22
HRP20020025A2 (en) 2003-12-31
CZ20014285A3 (cs) 2002-07-17
CA2374755C (en) 2010-03-30
BG65561B1 (bg) 2008-12-30
NO327746B1 (no) 2009-09-14
AU5311900A (en) 2001-01-02
HUP0201601A2 (en) 2002-10-28
EE200100672A (et) 2003-02-17
JP3904452B2 (ja) 2007-04-11
AP1397A (en) 2005-04-19
HK1076626A1 (en) 2006-01-20
JP2003502308A (ja) 2003-01-21
ATE419231T1 (de) 2009-01-15
IS6181A (is) 2001-11-28
UA72519C2 (en) 2005-03-15
CN1310872C (zh) 2007-04-18
HUP0201601A3 (en) 2002-11-28
CY1108827T1 (el) 2014-04-09
EP1192125A2 (en) 2002-04-03
SK287399B6 (sk) 2010-08-09
IL146969A0 (en) 2002-08-14
AU776723C (en) 2005-06-02
MA26804A1 (fr) 2004-12-20
AP2002002388A0 (en) 2002-03-31
NO20015949D0 (no) 2001-12-05
PE20010285A1 (es) 2001-03-22
EA200101134A1 (ru) 2002-06-27
RS50352B (sr) 2009-11-10
ZA200109711B (en) 2003-03-20
KR100694735B1 (ko) 2007-03-14
IL146969A (en) 2008-03-20
CZ300834B6 (cs) 2009-08-19
CZ301608B6 (cs) 2010-04-28
AU776723B2 (en) 2004-09-16
CA2689997A1 (en) 2000-12-21
CN1660779A (zh) 2005-08-31
CN1355784A (zh) 2002-06-26
CR6529A (es) 2003-11-25
BR0011727A (pt) 2002-03-05
NO20015949L (no) 2001-12-05
DE60041256D1 (de) 2009-02-12
HK1046401A1 (en) 2003-01-10
NO20091094L (no) 2001-12-05
SK17642001A3 (sk) 2002-10-08
ES2317839T3 (es) 2009-05-01

Similar Documents

Publication Publication Date Title
BG106292A (bg) Моно- и дизаместени 3-пропил гама - аминомаслени киселини
MX9806069A (es) Novedosos amino acidos ciclicos substituidos como agentes farmaceuticos.
HRP970560B1 (en) Substituted gamma aminobutyric acids as pharmaceutical agents
ZA972199B (en) Novel bridged cyclic amino acids as pharmaceutical agents.
CA2304965A1 (en) ((cyclo)alkyl substituted)-gamma-aminobutyric acid derivatives (=gaba analogues), their preparation and their use in the treatment of neurological disorders
DE69921340D1 (de) Verzweigte alkylpyrrolidin-3-carbonsäuren
ZA97991B (en) Novel cyclic amino acids as pharmaceutical agents.
GEP20043297B (en) Bicyclic Amino Acids as Pharmaceutical Agents
GEP20094817B (en) Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
AU4673300A (en) Amino heterocycles useful as pharmaceutical agents
CA2245647A1 (en) Novel bridged cyclic amino acids as pharmaceutical agents
ECSP003522A (es) Acidos 3- propilgamma- aminobutiricos mono- y, disustituidos