YU87001A - Mono i disupstituisane 3-propil gama-aminobuterne kiseline - Google Patents

Mono i disupstituisane 3-propil gama-aminobuterne kiseline

Info

Publication number
YU87001A
YU87001A YU87001A YUP87001A YU87001A YU 87001 A YU87001 A YU 87001A YU 87001 A YU87001 A YU 87001A YU P87001 A YUP87001 A YU P87001A YU 87001 A YU87001 A YU 87001A
Authority
YU
Yugoslavia
Prior art keywords
disorders
disubstituted
mono
aminobutyric acids
propyl gamma
Prior art date
Application number
YU87001A
Other languages
English (en)
Inventor
Thomas Richard Belliotti
Justin Stephen Bryans
Ihoezo Victor Ekhato
Augustine Tobi Osuma
Robert Michael Schelkun
Jacob Bradley Schwarz
Andrew John Thorpe
Lawrence David Wise
David Juergen Wustrow
Po-Wai Yuen
Original Assignee
Warner Lambrert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambrert Company filed Critical Warner Lambrert Company
Publication of YU87001A publication Critical patent/YU87001A/sh
Publication of RS50352B publication Critical patent/RS50352B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Ovaj pronalazak je niz novih mono-i disupstituisanih 3-propil gama aminobuternih kiselina formule (I). Jedinjenja su korisna kao terapeutska sredstva pri lečenju epilepsije, napada nesvesti, hipokinezije, poremećaja lobanje, neurodegenerativnih poremećaja, depresije, uznemirenosti, panike, bola, neuropatoloških poremećaja, artritisa, poremećaja spavanja, IBS i želudačnih poremećaja. Takodje deo pronalaska su postupci za pripremanje jedinjenja i korisnih intermedijera.
YUP-870/01A 1999-06-10 2000-05-31 Monosupstituisane 3-propil gama-aminobuterne kiseline RS50352B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13848599P 1999-06-10 1999-06-10

Publications (2)

Publication Number Publication Date
YU87001A true YU87001A (sh) 2004-07-15
RS50352B RS50352B (sr) 2009-11-10

Family

ID=22482232

Country Status (43)

Country Link
EP (1) EP1192125B9 (sh)
JP (1) JP3904452B2 (sh)
KR (1) KR100694735B1 (sh)
CN (2) CN1196671C (sh)
AP (1) AP1397A (sh)
AR (1) AR033335A1 (sh)
AT (1) ATE419231T1 (sh)
AU (1) AU776723C (sh)
BG (1) BG65561B1 (sh)
BR (1) BR0011727A (sh)
CA (2) CA2689997A1 (sh)
CO (1) CO5200791A1 (sh)
CR (1) CR6529A (sh)
CU (1) CU23101A3 (sh)
CY (1) CY1108827T1 (sh)
CZ (2) CZ300834B6 (sh)
DE (1) DE60041256D1 (sh)
DK (1) DK1192125T3 (sh)
DZ (1) DZ3253A1 (sh)
EA (1) EA004398B1 (sh)
EE (1) EE200100672A (sh)
ES (1) ES2317839T3 (sh)
GE (1) GEP20074142B (sh)
HK (2) HK1046401B (sh)
HR (1) HRP20020025A2 (sh)
HU (1) HUP0201601A3 (sh)
IL (2) IL146969A0 (sh)
IS (1) IS6181A (sh)
MA (1) MA26804A1 (sh)
ME (1) MEP44808A (sh)
MX (1) MXPA01012319A (sh)
NO (2) NO327746B1 (sh)
NZ (1) NZ515668A (sh)
OA (1) OA11962A (sh)
PE (1) PE20010285A1 (sh)
PT (1) PT1192125E (sh)
RS (2) RS20090257A (sh)
SI (1) SI1192125T1 (sh)
SK (2) SK287247B6 (sh)
TR (1) TR200103587T2 (sh)
UA (1) UA72519C2 (sh)
WO (1) WO2000076958A2 (sh)
ZA (1) ZA200109711B (sh)

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US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US6620829B2 (en) 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
MXPA03011566A (es) * 2001-06-11 2004-10-28 Xenoport Inc Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida.
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
MXPA04004105A (es) * 2002-01-31 2004-11-29 Warner Lambert Co Metodo de tratamiento de tinnitus.
NI200300043A (es) 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
US20030225149A1 (en) * 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
US7071339B2 (en) 2002-08-29 2006-07-04 Warner Lambert Company Llc Process for preparing functionalized γ-butyrolactones from mucohalic acid
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
ES2341240T3 (es) 2002-12-13 2010-06-17 Warner-Lambert Company Llc Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
RU2353358C2 (ru) 2002-12-13 2009-04-27 Уорнер-Ламберт Компани Ллс Производные прегабалина для лечения приливов
EP1572187A1 (en) * 2002-12-13 2005-09-14 Warner-Lambert Company LLC Pregabalin and derivatives thereof for the treatment of fibromyalgia and other related disorders
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
WO2005002585A1 (en) * 2003-07-02 2005-01-13 Warner-Lambert Company Llc Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
KR100828218B1 (ko) 2003-09-12 2008-05-07 화이자 인코포레이티드 알파-2-델타 리간드 및 세로토닌/노르아드레날린 재흡수 억제제를 포함하는 조합물
CA2540247C (en) 2003-09-25 2011-01-25 Warner-Lambert Company Llc Prodrugs of amino acids with affinity for the .alpha.2.delta.-protein
OA13258A (en) * 2003-09-25 2007-01-31 Warner Lambert Co Amino acids with affinity for the alpha2delta-protein.
WO2006043171A2 (en) * 2004-10-23 2006-04-27 Warner-Lambert Company Llc Methods of using alpha2delta-1 selective compounds
EA016518B1 (ru) * 2005-09-15 2012-05-30 Юсб Фарма, С.А. 4-замещенные пирролидин-2-оны и их применение
US20070141684A1 (en) 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
CN101600458A (zh) 2006-12-22 2009-12-09 瑞蔻达蒂爱尔兰有限公司 采用α2δ配体和NSAID的下泌尿道疾病的联合治疗
WO2009136375A1 (en) * 2008-05-08 2009-11-12 Pfizer Inc Treatment of interstitial cystitis
EP2509596B1 (en) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminoacids for treating ocular disorders
CN101914031B (zh) * 2010-07-30 2013-08-28 中国广州分析测试中心 普瑞巴林衍生物及其应用
JP6800968B2 (ja) * 2015-10-23 2020-12-16 ナビター ファーマシューティカルズ， インコーポレイテッド セストリン−ｇａｔｏｒ２相互作用のモジュレーターおよびその使用

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DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
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BR9712651A (pt) * 1996-10-23 1999-10-26 Warner Lambert Co ‡cidos gama-aminobutìricos substituìdos com agentes farmacêuticos.
PL199794B1 (pl) * 1997-10-27 2008-10-31 Warner Lambert Co Związki pośrednie do wytwarzania pochodnych cyklicznych aminokwasów

Also Published As

Publication number Publication date
CA2689997A1 (en) 2000-12-21
ZA200109711B (en) 2003-03-20
EE200100672A (et) 2003-02-17
RS50352B (sr) 2009-11-10
AR033335A1 (es) 2003-12-17
RS20090257A (en) 2010-03-02
NO20015949D0 (no) 2001-12-05
HK1076626A1 (en) 2006-01-20
CN1660779A (zh) 2005-08-31
CN1196671C (zh) 2005-04-13
CZ301608B6 (cs) 2010-04-28
OA11962A (en) 2006-04-17
HUP0201601A3 (en) 2002-11-28
IS6181A (is) 2001-11-28
EP1192125B1 (en) 2008-12-31
BR0011727A (pt) 2002-03-05
AU776723B2 (en) 2004-09-16
KR100694735B1 (ko) 2007-03-14
UA72519C2 (en) 2005-03-15
CA2374755A1 (en) 2000-12-21
PL352431A1 (en) 2003-08-25
SK287247B6 (sk) 2010-04-07
ES2317839T3 (es) 2009-05-01
HRP20020025A2 (en) 2003-12-31
JP3904452B2 (ja) 2007-04-11
CN1355784A (zh) 2002-06-26
CZ20014285A3 (cs) 2002-07-17
AU776723C (en) 2005-06-02
HK1046401A1 (en) 2003-01-10
AP2002002388A0 (en) 2002-03-31
MA26804A1 (fr) 2004-12-20
EA200101134A1 (ru) 2002-06-27
EP1192125A2 (en) 2002-04-03
IL146969A0 (en) 2002-08-14
NO20015949L (no) 2001-12-05
CZ300834B6 (cs) 2009-08-19
BG65561B1 (bg) 2008-12-30
DZ3253A1 (fr) 2000-12-21
ATE419231T1 (de) 2009-01-15
HUP0201601A2 (en) 2002-10-28
NZ515668A (en) 2004-02-27
JP2003502308A (ja) 2003-01-21
AU5311900A (en) 2001-01-02
NO20091094L (no) 2001-12-05
PE20010285A1 (es) 2001-03-22
DK1192125T3 (da) 2009-02-16
GEP20074142B (en) 2007-07-10
KR20020009631A (ko) 2002-02-01
CO5200791A1 (es) 2002-09-27
PT1192125E (pt) 2009-03-05
WO2000076958A3 (en) 2001-04-12
NO327746B1 (no) 2009-09-14
BG106292A (en) 2002-05-31
AP1397A (en) 2005-04-19
EP1192125B9 (en) 2009-09-16
CA2374755C (en) 2010-03-30
EA004398B1 (ru) 2004-04-29
MXPA01012319A (es) 2002-07-22
SK287399B6 (sk) 2010-08-09
MEP44808A (en) 2011-02-10
DE60041256D1 (de) 2009-02-12
CN1310872C (zh) 2007-04-18
SK17642001A3 (sk) 2002-10-08
CR6529A (es) 2003-11-25
CY1108827T1 (el) 2014-04-09
SI1192125T1 (sl) 2009-04-30
HK1046401B (zh) 2005-12-02
CU23101A3 (es) 2005-12-20
WO2000076958A2 (en) 2000-12-21
IL146969A (en) 2008-03-20
TR200103587T2 (tr) 2002-04-22

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