PT1181294E - Novos derivados e analogos da galantamina - Google Patents

Novos derivados e analogos da galantamina

Info

Publication number
PT1181294E
PT1181294E PT01914813T PT01914813T PT1181294E PT 1181294 E PT1181294 E PT 1181294E PT 01914813 T PT01914813 T PT 01914813T PT 01914813 T PT01914813 T PT 01914813T PT 1181294 E PT1181294 E PT 1181294E
Authority
PT
Portugal
Prior art keywords
new
analogs
galantamine derivatives
galantamine
derivatives
Prior art date
Application number
PT01914813T
Other languages
English (en)
Inventor
Ulrich Jordis
Johannes Frohlich
Matthias Treu
Manfred Hirnschall
Laszlo Czollner
Beate Kalz
Stefan Welzig
Original Assignee
Sanochemia Pharmazeutika Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanochemia Pharmazeutika Ag filed Critical Sanochemia Pharmazeutika Ag
Publication of PT1181294E publication Critical patent/PT1181294E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
PT01914813T 2000-03-31 2001-03-22 Novos derivados e analogos da galantamina PT1181294E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT5462000 2000-03-31
AT2382001 2001-02-15

Publications (1)

Publication Number Publication Date
PT1181294E true PT1181294E (pt) 2004-07-30

Family

ID=25608130

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01914813T PT1181294E (pt) 2000-03-31 2001-03-22 Novos derivados e analogos da galantamina

Country Status (26)

Country Link
US (2) US7166588B2 (pt)
EP (1) EP1181294B1 (pt)
JP (1) JP2003529602A (pt)
CN (1) CN1380883A (pt)
AT (1) ATE263171T1 (pt)
AU (1) AU785385B2 (pt)
BG (1) BG65134B1 (pt)
BR (1) BR0105563A (pt)
CA (1) CA2368966A1 (pt)
CZ (1) CZ300160B6 (pt)
DE (1) DE50101827D1 (pt)
DK (1) DK1181294T3 (pt)
ES (1) ES2215885T3 (pt)
HK (2) HK1045990A1 (pt)
HU (1) HUP0202233A3 (pt)
IS (1) IS2287B (pt)
MX (1) MXPA01012275A (pt)
NO (1) NO326458B1 (pt)
NZ (1) NZ516302A (pt)
PL (1) PL202463B1 (pt)
PT (1) PT1181294E (pt)
RU (1) RU2241001C2 (pt)
SI (1) SI1181294T1 (pt)
SK (1) SK285909B6 (pt)
TR (1) TR200400857T4 (pt)
WO (1) WO2001074820A1 (pt)

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Publication number Priority date Publication date Assignee Title
JP4721386B2 (ja) * 2001-07-10 2011-07-13 第一三共株式会社 新規ガランタミン類縁体
US20060069251A1 (en) * 2002-03-25 2006-03-30 Ulrich Jordis Methods for producing norgalanthamine, as well as isomers, salts and hydrates thereof
AT414125B (de) * 2003-09-29 2006-09-15 Sanochemia Pharmazeutika Ag Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln
AT500143A1 (de) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
US7877350B2 (en) * 2005-06-27 2011-01-25 Ab Initio Technology Llc Managing metadata for graph-based computations
DE602006015338D1 (de) * 2005-09-22 2010-08-19 Galantos Pharma Gmbh Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2008022365A2 (de) * 2006-08-24 2008-02-28 Sanochemia Ltd. Mittel zum beeinflussen der wirkungen von organophosphorverbindungen und verwendung von galanthamin, dessen derivaten und analoga zum herstellen solcher mittel
DK2137192T3 (da) 2008-04-14 2014-05-26 Neurodyn Life Sciences Inc Derivater af galantamin som prodrugs til behandling af humane hjernesygdomme
BG110141A (en) * 2008-05-23 2009-12-31 "Софарма" Ад GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE
AU2011268459B2 (en) 2010-06-15 2014-09-18 Ab Initio Technology Llc Dynamically loading graph-based computations
WO2013160728A1 (en) 2012-04-26 2013-10-31 Alma Mater Studiorum - Universita' Di Bologna Dual targeting compounds for the treatment of alzheimer's disease
US10108521B2 (en) * 2012-11-16 2018-10-23 Ab Initio Technology Llc Dynamic component performance monitoring
SG11201604525TA (en) 2013-12-05 2016-07-28 Ab Initio Technology Llc Managing interfaces for dataflow graphs composed of sub-graphs
AU2015312010B2 (en) 2014-09-02 2019-10-03 Ab Initio Technology Llc. Visually specifying subsets of components in graph-based programs through user interactions
CN107077364B (zh) 2014-09-02 2021-06-04 起元科技有限公司 基于特定数据端口连接的识别使用图组件的自动聚类的基于图的程序规范的编译
US10657134B2 (en) 2015-08-05 2020-05-19 Ab Initio Technology Llc Selecting queries for execution on a stream of real-time data

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US3947445A (en) * 1974-05-09 1976-03-30 Stanford Research Institute Diazabicyclooctanes and diazabicycloheptanes
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
KR100195399B1 (ko) 1987-05-04 1999-06-15 보니데이비스 알쯔하이머 병 치료용 의약
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
US4954502A (en) 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
US5153193A (en) * 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US6323195B1 (en) 1993-10-15 2001-11-27 Aventis Pharmaceuticals Inc. Galanthamine derivatives as acetylcholinesterase inhibitors
US6323196B1 (en) 1993-10-15 2001-11-27 Aventis Pharmaceuticals Inc. Galanthamine derivatives as acetylcholinesterase inhibitors
US5428159A (en) * 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
US6407229B1 (en) 1994-10-21 2002-06-18 Sanochemia Pharmazeutika Ag Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine
AT401058B (de) 1994-10-21 1996-06-25 Waldheim Pharmazeutika Gmbh Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins
BR9509406A (pt) * 1994-10-21 1998-11-03 Waldheim Pharmazeutica Ges M B Processo para a preparação de 4a,5,9,10,11,12,-hedaxidro-6h-benzofuro(3a,3,2,-ef) [2] benzazepina
GB9514821D0 (en) * 1995-07-19 1995-09-20 Sod Conseils Rech Applic Galanthamine derivatives
GB9519268D0 (en) 1995-09-21 1995-11-22 Chiroscience Ltd Preparation of alkaloids
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
WO2000032199A1 (de) * 1998-12-01 2000-06-08 Sanochemia Pharmazeutika Aktiengesellschaft Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden
AT414125B (de) 2003-09-29 2006-09-15 Sanochemia Pharmazeutika Ag Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
BG106155A (en) 2002-08-30
EP1181294B1 (de) 2004-03-31
CN1380883A (zh) 2002-11-20
CZ20014178A3 (cs) 2002-11-13
SK285909B6 (sk) 2007-10-04
WO2001074820A1 (de) 2001-10-11
IS6174A (is) 2001-11-23
EP1181294A1 (de) 2002-02-27
IS2287B (is) 2007-10-15
TR200400857T4 (tr) 2004-06-21
JP2003529602A (ja) 2003-10-07
ES2215885T3 (es) 2004-10-16
PL202463B1 (pl) 2009-06-30
HUP0202233A2 (hu) 2002-11-28
PL352638A1 (en) 2003-09-08
BG65134B1 (bg) 2007-03-30
NZ516302A (en) 2004-02-27
US20030199493A1 (en) 2003-10-23
ATE263171T1 (de) 2004-04-15
NO20015857L (no) 2002-01-29
NO326458B1 (no) 2008-12-08
MXPA01012275A (es) 2003-06-24
BR0105563A (pt) 2002-04-02
RU2241001C2 (ru) 2004-11-27
US20070027138A1 (en) 2007-02-01
US7166588B2 (en) 2007-01-23
DK1181294T3 (da) 2004-08-02
CA2368966A1 (en) 2001-10-11
SI1181294T1 (en) 2004-08-31
NO20015857D0 (no) 2001-11-30
HK1049832A1 (zh) 2003-05-30
AU4208501A (en) 2001-10-15
SK17022001A3 (sk) 2003-02-04
HUP0202233A3 (en) 2004-12-28
HK1045990A1 (en) 2002-12-20
DE50101827D1 (de) 2004-05-06
AU785385B2 (en) 2007-03-29
CZ300160B6 (cs) 2009-02-25

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