PE20020209A1 - Derivados de 1-amino-6-isoquinolinil como inhibidores de trombina - Google Patents

Derivados de 1-amino-6-isoquinolinil como inhibidores de trombina

Info

Publication number
PE20020209A1
PE20020209A1 PE2001000684A PE2001000684A PE20020209A1 PE 20020209 A1 PE20020209 A1 PE 20020209A1 PE 2001000684 A PE2001000684 A PE 2001000684A PE 2001000684 A PE2001000684 A PE 2001000684A PE 20020209 A1 PE20020209 A1 PE 20020209A1
Authority
PE
Peru
Prior art keywords
derivatives
amino
isoquinolinil
thrombin inhibitors
cyclohexyl
Prior art date
Application number
PE2001000684A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Johannes Bernardus Maria Rewinkel
Paolo Giovanni Martino Conti
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20020209A1 publication Critical patent/PE20020209A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE 1-AMINO-6-ISOQUINOLINIL DE FORMULA I DONDE R1 ES CICLOPENTILO, CICLOHEXILO, ALQUILO C3-C4; R2 ES CICLOHEXILO, FENILO; R3 ES METILO; A ES UN ANILLO DE 4-6 MIEMBROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. EL COMPUESTO DE FORMULA I ES INHIBIDOR DE TROMBINA Y ES UTIL PARA EL TRATAMIENTO DE ESTADOS TROMBOTICOS COMO TROMBOSIS VENOSA PROFUNDA, EMBOLIA PULMONAR, TROMBOFLEBITIS
PE2001000684A 2000-07-12 2001-07-10 Derivados de 1-amino-6-isoquinolinil como inhibidores de trombina PE20020209A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00202491 2000-07-12

Publications (1)

Publication Number Publication Date
PE20020209A1 true PE20020209A1 (es) 2002-03-19

Family

ID=8171793

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000684A PE20020209A1 (es) 2000-07-12 2001-07-10 Derivados de 1-amino-6-isoquinolinil como inhibidores de trombina

Country Status (23)

Country Link
US (1) US6642253B2 (es)
EP (1) EP1303491A1 (es)
JP (1) JP2004502759A (es)
KR (1) KR20030022270A (es)
CN (1) CN1441784A (es)
AR (1) AR029596A1 (es)
AU (1) AU2001278476A1 (es)
BR (1) BR0112338A (es)
CA (1) CA2413035A1 (es)
CZ (1) CZ200392A3 (es)
EC (1) ECSP034422A (es)
HR (1) HRP20030017A2 (es)
HU (1) HUP0301258A2 (es)
IL (1) IL153611A0 (es)
MX (1) MXPA03000337A (es)
NO (1) NO20030145L (es)
NZ (1) NZ523553A (es)
PE (1) PE20020209A1 (es)
PL (1) PL359787A1 (es)
RU (1) RU2003104017A (es)
SK (1) SK322003A3 (es)
WO (1) WO2002004423A1 (es)
ZA (1) ZA200300080B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642252B2 (en) 2000-11-07 2003-11-04 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
US6906192B2 (en) 2000-11-07 2005-06-14 Bristol Myers Squibb Company Processes for the preparation of acid derivatives useful as serine protease inhibitors
TWI389899B (zh) * 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑
PT2102164E (pt) * 2006-12-27 2011-01-21 Sanofi Aventis Derivados de isoquinolina e de isoquinolinona substituída com cicloalquilamina
US7927378B2 (en) * 2007-03-05 2011-04-19 Scussel Sbj Systems, Llc Vacuum assisted prosthetic sleeve and socket
CN109810172B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-PARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810173B (zh) * 2017-11-21 2020-11-27 首都医科大学 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810174B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Medicinal compounds

Also Published As

Publication number Publication date
HUP0301258A2 (hu) 2003-08-28
AR029596A1 (es) 2003-07-02
HRP20030017A2 (en) 2003-04-30
IL153611A0 (en) 2003-07-06
AU2001278476A1 (en) 2002-01-21
BR0112338A (pt) 2003-07-22
WO2002004423A1 (en) 2002-01-17
EP1303491A1 (en) 2003-04-23
US20030166579A1 (en) 2003-09-04
ZA200300080B (en) 2004-04-05
KR20030022270A (ko) 2003-03-15
NZ523553A (en) 2004-04-30
RU2003104017A (ru) 2004-08-20
PL359787A1 (en) 2004-09-06
WO2002004423A8 (en) 2003-03-06
WO2002004423A9 (en) 2003-05-15
MXPA03000337A (es) 2004-04-05
NO20030145D0 (no) 2003-01-10
JP2004502759A (ja) 2004-01-29
SK322003A3 (en) 2003-06-03
US6642253B2 (en) 2003-11-04
CN1441784A (zh) 2003-09-10
CA2413035A1 (en) 2002-01-17
ECSP034422A (es) 2003-03-10
CZ200392A3 (cs) 2003-05-14
NO20030145L (no) 2003-01-10

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