PE20011314A1 - DERIVADOS DE N-(4-CARBAMIMIDOIL-FENIL)-GLICINA COMO INHIBIDORES DE LA FORMACION DE FACTORES DE COAGULACION Xa IXa Y TROMBINA - Google Patents
DERIVADOS DE N-(4-CARBAMIMIDOIL-FENIL)-GLICINA COMO INHIBIDORES DE LA FORMACION DE FACTORES DE COAGULACION Xa IXa Y TROMBINAInfo
- Publication number
- PE20011314A1 PE20011314A1 PE2001000442A PE2001000442A PE20011314A1 PE 20011314 A1 PE20011314 A1 PE 20011314A1 PE 2001000442 A PE2001000442 A PE 2001000442A PE 2001000442 A PE2001000442 A PE 2001000442A PE 20011314 A1 PE20011314 A1 PE 20011314A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- carbamimidoyl
- glycin
- derivatives
- ixa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE N-(4-CARBAMIMIDOIL-FENIL)-GLICINA DE FORMULA I DONDE R1 ES ALQUILO; R2 ES H, HIDROXIALCOXILO, ALCOXICARBONILOXI, ALCOXILO, ENTRE OTROS; R3 ES H, ALCOXILO, HETEROCICLOALQUILOXILO; R4 ES H, ESTER; R5 ES H, HIDROXILO, ALCOXICARBONILO, HALOGENOALCOXICARBONILO, ENTRE OTROS; X ES F, Cl, Br. SON COMPUESTOS PREFERIDOS ESTER ETILICO DEL ACIDO (RS)-(4-CARBAMIMIDOIL-FENILAMINO)-3,5-DIETOXI-2-FLUORO-FENIL-ACETICO, ACIDO (RS)-(4-CARBAMIMIDOIL-FENILAMINO)-(2-FLUORO-3,5-DIMETOXI-FENIL)-ACETICO, ESTER ETILICO DEL ACIDO (RS)-(4-CARBAMIMIDOIL-FENILAMINO)-(2-FLUORO-3,5-DIMETOXI-FENIL)-ACETICO. LOS DERIVADOS DE N-(4-CARBAMIMIDOIL-FENIL)-GLICINA SON INHIBIDORES DE LA FORMACION DE FACTORES DE COAGULACION Xa IXa Y TROMBINA Y SON UTILES PARA LA PREVENCION Y TRATAMIENTO DE TROMBOSIS, APOPLEJIA, INFARTO CARDIACO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00110881 | 2000-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20011314A1 true PE20011314A1 (es) | 2002-01-04 |
Family
ID=8168800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000442A PE20011314A1 (es) | 2000-05-23 | 2001-05-17 | DERIVADOS DE N-(4-CARBAMIMIDOIL-FENIL)-GLICINA COMO INHIBIDORES DE LA FORMACION DE FACTORES DE COAGULACION Xa IXa Y TROMBINA |
Country Status (23)
Country | Link |
---|---|
US (1) | US6548694B2 (es) |
EP (1) | EP1289939A1 (es) |
JP (1) | JP3842132B2 (es) |
KR (1) | KR100569517B1 (es) |
CN (1) | CN1305839C (es) |
AR (1) | AR028596A1 (es) |
AU (2) | AU2001281774B2 (es) |
BR (1) | BR0110998A (es) |
CA (1) | CA2408602C (es) |
EC (1) | ECSP024360A (es) |
HU (1) | HUP0302073A2 (es) |
IL (1) | IL152581A0 (es) |
MA (1) | MA26905A1 (es) |
MX (1) | MXPA02011466A (es) |
NO (1) | NO20025590D0 (es) |
NZ (1) | NZ522412A (es) |
PE (1) | PE20011314A1 (es) |
PL (1) | PL361355A1 (es) |
RU (1) | RU2268257C2 (es) |
UY (1) | UY26721A1 (es) |
WO (1) | WO2001090051A1 (es) |
YU (1) | YU83602A (es) |
ZA (1) | ZA200208899B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100473966B1 (ko) * | 1998-12-14 | 2005-03-08 | 에프. 호프만-라 로슈 아게 | 페닐글리신 유도체 |
DE10300049A1 (de) * | 2003-01-03 | 2004-07-15 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Faktor VIIa inhibieren |
US6642386B2 (en) * | 2002-02-06 | 2003-11-04 | Hoffmann-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
GB0211931D0 (en) * | 2002-05-23 | 2002-07-03 | Univ Liverpool | Methods & device utilizing adsorption of molecules at a surface or interface |
TW200410921A (en) * | 2002-11-25 | 2004-07-01 | Hoffmann La Roche | Mandelic acid derivatives |
JP2006517589A (ja) | 2003-02-11 | 2006-07-27 | ブリストル−マイヤーズ スクイブ カンパニー | セリンプロテアーゼ・インヒビターとして有用なベンゼンアセトアミド化合物 |
EP1594505A4 (en) | 2003-02-11 | 2008-08-13 | Bristol Myers Squibb Co | PHENYLGLYCIN DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS |
DE10306202A1 (de) * | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen |
US7917130B1 (en) | 2003-03-21 | 2011-03-29 | Stratosaudio, Inc. | Broadcast response method and system |
US7776804B2 (en) * | 2005-03-16 | 2010-08-17 | The Lubrizol Corporation | Viscosity improver compositions providing improved low temperature characteristics to lubricating oil |
US7056932B2 (en) * | 2003-12-19 | 2006-06-06 | Hoffman-La Roche Inc. | Heterocyclyl substituted 1-alkoxy acetic acid amides |
JP4478157B2 (ja) * | 2004-10-13 | 2010-06-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヒドラジド誘導体 |
CA2584485C (en) * | 2004-10-20 | 2013-12-31 | Resverlogix Corp. | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
TW200637843A (en) | 2005-01-10 | 2006-11-01 | Bristol Myers Squibb Co | Phenylglycinamide derivatives useful as anticoagulants |
DE602006011752D1 (de) * | 2005-06-24 | 2010-03-04 | Bristol Myers Squibb Co | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
US8044242B2 (en) | 2006-03-09 | 2011-10-25 | Bristol-Myers Squibb Company | 2-(aryloxy) acetamide factor VIIa inhibitors useful as anticoagulants |
EP2000465B1 (en) * | 2006-03-24 | 2010-12-15 | Eisai R&D Management Co., Ltd. | Triazolone derivative |
US7855194B2 (en) | 2006-03-27 | 2010-12-21 | Hoffmann-La Roche Inc. | Pyrimidine, quinazoline, pteridine and triazine derivatives |
JP5236664B2 (ja) | 2007-02-01 | 2013-07-17 | レスバーロジックス コーポレイション | 心血管疾患を予防および治療するための化合物 |
EP1967522A1 (en) * | 2007-03-07 | 2008-09-10 | Novo Nordisk A/S | New blood coagulation factor inhibitors |
US7807690B2 (en) * | 2007-09-21 | 2010-10-05 | Eisai R&D Management Co., Ltd. | 2,3-dihydro-iminoisoindole derivatives |
US8631448B2 (en) | 2007-12-14 | 2014-01-14 | Stratosaudio, Inc. | Systems and methods for scheduling interactive media and events |
AU2009262252B2 (en) * | 2008-06-26 | 2013-05-02 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
CA2747417C (en) | 2009-01-08 | 2017-01-03 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
NZ708314A (en) | 2009-03-18 | 2017-08-25 | Resverlogix Corp | Quinazolinones for use as anticancer agents |
BRPI1014956B8 (pt) | 2009-04-22 | 2021-05-25 | Resverlogix Corp | agentes anti-inflamatórios |
CN102887836B (zh) * | 2011-07-18 | 2014-03-26 | 西南大学 | L-苯甘氨酸衍生物及其应用 |
GB201118876D0 (en) * | 2011-11-01 | 2011-12-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
CA2851996C (en) | 2011-11-01 | 2020-01-07 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
MX2015007921A (es) | 2012-12-21 | 2016-03-03 | Zenith Epigenetics Corp | Compuestos heterociclicos novedosos como inhibidores de bromodominio. |
JP6903585B2 (ja) | 2015-03-13 | 2021-07-14 | レスバーロジックス コーポレイション | 補体関連疾患の治療のための組成物および治療方法 |
CN111072562B (zh) * | 2019-11-07 | 2021-12-07 | 中山大学 | 一种四氢异喹啉衍生物及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0921116T3 (da) | 1997-12-04 | 2003-10-06 | Hoffmann La Roche | N-(4-carbamimido-phenyl)-glycinamidderivater |
EP1078917A4 (en) | 1998-02-17 | 2002-11-06 | Ono Pharmaceutical Co | AMIDINO DERIVATIVES FOR USE AS ACTIVE INGREDIENTS AND MEDICINES CONTAINING THEM |
KR100473966B1 (ko) * | 1998-12-14 | 2005-03-08 | 에프. 호프만-라 로슈 아게 | 페닐글리신 유도체 |
-
2001
- 2001-05-16 US US09/858,535 patent/US6548694B2/en not_active Expired - Fee Related
- 2001-05-17 MX MXPA02011466A patent/MXPA02011466A/es active IP Right Grant
- 2001-05-17 EP EP01960221A patent/EP1289939A1/en not_active Withdrawn
- 2001-05-17 IL IL15258101A patent/IL152581A0/xx unknown
- 2001-05-17 HU HU0302073A patent/HUP0302073A2/hu unknown
- 2001-05-17 AU AU2001281774A patent/AU2001281774B2/en not_active Ceased
- 2001-05-17 CA CA002408602A patent/CA2408602C/en not_active Expired - Fee Related
- 2001-05-17 BR BR0110998-7A patent/BR0110998A/pt not_active IP Right Cessation
- 2001-05-17 PE PE2001000442A patent/PE20011314A1/es not_active Application Discontinuation
- 2001-05-17 NZ NZ522412A patent/NZ522412A/en unknown
- 2001-05-17 AU AU8177401A patent/AU8177401A/xx active Pending
- 2001-05-17 JP JP2001586241A patent/JP3842132B2/ja not_active Expired - Fee Related
- 2001-05-17 WO PCT/EP2001/005633 patent/WO2001090051A1/en active IP Right Grant
- 2001-05-17 YU YU83602A patent/YU83602A/sh unknown
- 2001-05-17 PL PL36135501A patent/PL361355A1/xx not_active Application Discontinuation
- 2001-05-17 RU RU2002133215/04A patent/RU2268257C2/ru active
- 2001-05-17 CN CNB018099297A patent/CN1305839C/zh not_active Expired - Fee Related
- 2001-05-17 KR KR1020027015798A patent/KR100569517B1/ko not_active IP Right Cessation
- 2001-05-21 AR ARP010102385A patent/AR028596A1/es not_active Application Discontinuation
- 2001-05-22 UY UY26721A patent/UY26721A1/es not_active Application Discontinuation
-
2002
- 2002-11-01 ZA ZA200208899A patent/ZA200208899B/en unknown
- 2002-11-21 NO NO20025590A patent/NO20025590D0/no not_active Application Discontinuation
- 2002-11-22 EC EC2002004360A patent/ECSP024360A/es unknown
- 2002-11-22 MA MA26921A patent/MA26905A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0302073A2 (hu) | 2003-09-29 |
RU2268257C2 (ru) | 2006-01-20 |
NO20025590L (no) | 2002-11-21 |
ZA200208899B (en) | 2004-02-19 |
AU8177401A (en) | 2001-12-03 |
AU2001281774B2 (en) | 2005-03-10 |
JP3842132B2 (ja) | 2006-11-08 |
YU83602A (sh) | 2006-05-25 |
AR028596A1 (es) | 2003-05-14 |
US6548694B2 (en) | 2003-04-15 |
KR20030007678A (ko) | 2003-01-23 |
PL361355A1 (en) | 2004-10-04 |
NO20025590D0 (no) | 2002-11-21 |
JP2003534311A (ja) | 2003-11-18 |
US20020004608A1 (en) | 2002-01-10 |
BR0110998A (pt) | 2003-04-08 |
ECSP024360A (es) | 2003-03-31 |
UY26721A1 (es) | 2001-12-28 |
CN1430599A (zh) | 2003-07-16 |
CN1305839C (zh) | 2007-03-21 |
EP1289939A1 (en) | 2003-03-12 |
WO2001090051A1 (en) | 2001-11-29 |
CA2408602A1 (en) | 2001-11-29 |
KR100569517B1 (ko) | 2006-04-07 |
NZ522412A (en) | 2004-05-28 |
CA2408602C (en) | 2008-01-08 |
MXPA02011466A (es) | 2003-04-25 |
IL152581A0 (en) | 2003-05-29 |
MA26905A1 (fr) | 2004-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |