AR038480A1 - Derivados de fenilglicina solubles en agua - Google Patents
Derivados de fenilglicina solubles en aguaInfo
- Publication number
- AR038480A1 AR038480A1 ARP030100333A ARP030100333A AR038480A1 AR 038480 A1 AR038480 A1 AR 038480A1 AR P030100333 A ARP030100333 A AR P030100333A AR P030100333 A ARP030100333 A AR P030100333A AR 038480 A1 AR038480 A1 AR 038480A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- compounds
- phenylglycin
- derivatives
- water soluble
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Abstract
Estos compuestos inhiben la formación de factores de coagulación Xa, IXa y trombina inducidos por factor VIIa y factor tisular y pueden utilizarse como medicamentos. También se revela procedimientos para preparar los compuestos, intermediarios, composiciones farmacéuticas método de tratamiento y uso. Reivindicación 1: Compuestos de la fórmula (1): en donde: R1 es alcoxilo inferior; R2 es halógeno; R3 es piperidinilo opcionalmente sustituido por alquilo inferior, hidroxi-alquilo inferior, carboxi-alquilo inferior o alcoxilo inferior-carbonil-alquilo inferior; R4 es hidrógeno o alquilo inferior; n es 0 a 3, y el grupo -(CH2)n puede estar sustituido opcionalmente por alquilo inferior; y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02002009 | 2002-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038480A1 true AR038480A1 (es) | 2005-01-19 |
Family
ID=27675597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100333A AR038480A1 (es) | 2002-02-06 | 2003-02-04 | Derivados de fenilglicina solubles en agua |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6642386B2 (es) |
| EP (1) | EP1474391A1 (es) |
| JP (1) | JP2005522435A (es) |
| KR (1) | KR20040082411A (es) |
| CN (1) | CN1628099A (es) |
| AR (1) | AR038480A1 (es) |
| AU (1) | AU2003244474B2 (es) |
| BR (1) | BR0307469A (es) |
| CA (1) | CA2474027A1 (es) |
| GT (1) | GT200300030A (es) |
| JO (1) | JO2241B1 (es) |
| MX (1) | MXPA04007500A (es) |
| PA (1) | PA8564801A1 (es) |
| PE (1) | PE20030905A1 (es) |
| PL (1) | PL372197A1 (es) |
| RU (1) | RU2283305C2 (es) |
| TW (1) | TW200303744A (es) |
| UY (1) | UY27653A1 (es) |
| WO (1) | WO2003066588A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200101744T2 (tr) * | 1998-12-14 | 2001-12-21 | F. Hoffmann-La Roche Ag | Fenilglisin türevleri. |
| EP1594845A4 (en) | 2003-02-11 | 2008-05-21 | Bristol Myers Squibb Co | BENZENE ACETAMIDE COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS |
| US7122559B2 (en) | 2003-02-11 | 2006-10-17 | Bristol-Myers Squibb Company | Phenylglycine derivatives useful as serine protease inhibitors |
| WO2006076246A2 (en) | 2005-01-10 | 2006-07-20 | Bristol-Myers Squibb Company | Phenylglycinamide derivatives useful as anticoagulants |
| ATE455103T1 (de) * | 2005-06-24 | 2010-01-15 | Bristol Myers Squibb Co | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200101744T2 (tr) | 1998-12-14 | 2001-12-21 | F. Hoffmann-La Roche Ag | Fenilglisin türevleri. |
| US6548694B2 (en) | 2000-05-23 | 2003-04-15 | Hoffman-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
-
2003
- 2003-01-24 US US10/350,617 patent/US6642386B2/en not_active Expired - Fee Related
- 2003-01-30 AU AU2003244474A patent/AU2003244474B2/en not_active Ceased
- 2003-01-30 WO PCT/EP2003/000937 patent/WO2003066588A1/en not_active Application Discontinuation
- 2003-01-30 CA CA002474027A patent/CA2474027A1/en not_active Abandoned
- 2003-01-30 JP JP2003565963A patent/JP2005522435A/ja active Pending
- 2003-01-30 KR KR10-2004-7012096A patent/KR20040082411A/ko not_active Application Discontinuation
- 2003-01-30 CN CNA038032619A patent/CN1628099A/zh active Pending
- 2003-01-30 EP EP03737293A patent/EP1474391A1/en not_active Withdrawn
- 2003-01-30 RU RU2004126940/04A patent/RU2283305C2/ru not_active IP Right Cessation
- 2003-01-30 PL PL03372197A patent/PL372197A1/xx not_active Application Discontinuation
- 2003-01-30 BR BR0307469-2A patent/BR0307469A/pt not_active IP Right Cessation
- 2003-01-30 MX MXPA04007500A patent/MXPA04007500A/es unknown
- 2003-02-02 JO JO200311A patent/JO2241B1/en active
- 2003-02-03 PE PE2003000123A patent/PE20030905A1/es not_active Application Discontinuation
- 2003-02-03 PA PA20038564801A patent/PA8564801A1/es unknown
- 2003-02-04 GT GT200300030A patent/GT200300030A/es unknown
- 2003-02-04 AR ARP030100333A patent/AR038480A1/es unknown
- 2003-02-05 UY UY27653A patent/UY27653A1/es not_active Application Discontinuation
- 2003-02-06 TW TW092102394A patent/TW200303744A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2283305C2 (ru) | 2006-09-10 |
| AU2003244474B2 (en) | 2006-05-11 |
| AU2003244474A1 (en) | 2003-09-02 |
| PE20030905A1 (es) | 2003-11-08 |
| PL372197A1 (en) | 2005-07-11 |
| UY27653A1 (es) | 2003-08-29 |
| US20030166683A1 (en) | 2003-09-04 |
| CA2474027A1 (en) | 2003-08-14 |
| JP2005522435A (ja) | 2005-07-28 |
| RU2004126940A (ru) | 2005-08-10 |
| PA8564801A1 (es) | 2003-12-10 |
| KR20040082411A (ko) | 2004-09-24 |
| JO2241B1 (en) | 2004-10-07 |
| TW200303744A (en) | 2003-09-16 |
| MXPA04007500A (es) | 2004-11-10 |
| US6642386B2 (en) | 2003-11-04 |
| BR0307469A (pt) | 2004-11-09 |
| GT200300030A (es) | 2003-09-12 |
| EP1474391A1 (en) | 2004-11-10 |
| WO2003066588A1 (en) | 2003-08-14 |
| CN1628099A (zh) | 2005-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |