AR048326A1 - Derivados de prolinilo - Google Patents
Derivados de proliniloInfo
- Publication number
- AR048326A1 AR048326A1 ARP050101135A ARP050101135A AR048326A1 AR 048326 A1 AR048326 A1 AR 048326A1 AR P050101135 A ARP050101135 A AR P050101135A AR P050101135 A ARP050101135 A AR P050101135A AR 048326 A1 AR048326 A1 AR 048326A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- coo
- derivatives
- nr5r5
- cona
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Compuestos de la formula (1) en donde R es Hal, -C:::C-H, -C:::C-A u OA, R1 es H, =O, Hal, A, OH, OA, A-COO-, Ph-(CH2)n-COO-, cicloalquil-(CH2)n-COO-, A-CONH-, A-CONA-, Ph-CONA-, N3, NH2, NO2, CN, COOH, COOA, CONH2, CONHA, CON(A)2, O-alilo, O- propargilo, O-bencilo, =N-OH, =N-OA o =CF2; R2 es H o A; Ph es fenilo insustituido o mono, di o trisustituido con A, OA, OH o Hal, R3 es H, Hal o A, R4 es -C6H4-(CH2)n-NR5R5', -C(=NR5)NR5R5', o como se muestra en los restos de formulas (2); R5, R5' son en cada caso, de modo independiente entre sí, H o A, A es alquilo no ramificado, ramificado o cíclico con C1-12, en donde también 1-7 átomos de H pueden estar reemplazados por F y/o Cl; Hal es F, Cl. Br o I; n es 0, 1, 2 o 3, así como sus derivados, solvatos, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones, son inhibidores del factor de coagulacion Xa y se pueden emplear para la prevencion y/o la terapia de enfermedades tromboembolicas y para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004014945A DE102004014945A1 (de) | 2004-03-26 | 2004-03-26 | Prolinylderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048326A1 true AR048326A1 (es) | 2006-04-19 |
Family
ID=34961159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101135A AR048326A1 (es) | 2004-03-26 | 2005-03-23 | Derivados de prolinilo |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7683093B2 (es) |
| EP (1) | EP1735279A1 (es) |
| JP (1) | JP2007530469A (es) |
| KR (1) | KR20070010131A (es) |
| CN (1) | CN1938269A (es) |
| AR (1) | AR048326A1 (es) |
| AU (1) | AU2005225489B2 (es) |
| BR (1) | BRPI0509174A (es) |
| CA (1) | CA2561057A1 (es) |
| DE (1) | DE102004014945A1 (es) |
| MX (1) | MXPA06010771A (es) |
| RU (1) | RU2006137656A (es) |
| WO (1) | WO2005092849A1 (es) |
| ZA (1) | ZA200608875B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004246766B2 (en) * | 2003-06-18 | 2009-09-17 | Merck Patent Gmbh | Pyrrolidin-1, 2- dicarboxylic acid- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative as inhibitors of coagulation factor Xa and VIIa for the treatment of thrombosis |
| DE10358814A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | Prolinylarylacetamide |
| EP1818330A1 (de) * | 2006-02-14 | 2007-08-15 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Prolinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| BRPI0711648A2 (pt) | 2006-05-16 | 2011-11-29 | Boehringer Ingelheim Int | prolinamidas substituìdas, fabricação e uso das mesmas como medicamentos |
| AR067336A1 (es) * | 2007-06-28 | 2009-10-07 | Novartis Ag | Moduladores de calicreina 7 |
| AR106241A1 (es) * | 2015-10-01 | 2017-12-27 | Biocryst Pharm Inc | Inhibidores de calicreína plasmática humana |
| CN110240591A (zh) * | 2018-03-08 | 2019-09-17 | 天津药物研究院有限公司 | 脯氨酸衍生物及其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199800157T1 (xx) * | 1995-07-31 | 1998-06-22 | Shionogi & Co.,Ltd. | Fosfolipaz A2 inhibit�r� aktivitesi olan pirolidin t�revleri. |
| US6673817B1 (en) | 1999-05-24 | 2004-01-06 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| JP2003500390A (ja) * | 1999-05-24 | 2003-01-07 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子阻害剤 |
| US7312235B2 (en) * | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
| US7030141B2 (en) | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
-
2004
- 2004-03-26 DE DE102004014945A patent/DE102004014945A1/de not_active Withdrawn
-
2005
- 2005-03-04 WO PCT/EP2005/002306 patent/WO2005092849A1/de active Application Filing
- 2005-03-04 KR KR1020067019772A patent/KR20070010131A/ko not_active Application Discontinuation
- 2005-03-04 CN CNA200580009735XA patent/CN1938269A/zh active Pending
- 2005-03-04 RU RU2006137656/04A patent/RU2006137656A/ru unknown
- 2005-03-04 JP JP2007504284A patent/JP2007530469A/ja active Pending
- 2005-03-04 AU AU2005225489A patent/AU2005225489B2/en not_active Ceased
- 2005-03-04 CA CA002561057A patent/CA2561057A1/en not_active Abandoned
- 2005-03-04 EP EP05715737A patent/EP1735279A1/de not_active Withdrawn
- 2005-03-04 US US10/594,024 patent/US7683093B2/en not_active Expired - Fee Related
- 2005-03-04 MX MXPA06010771A patent/MXPA06010771A/es not_active Application Discontinuation
- 2005-03-04 BR BRPI0509174-8A patent/BRPI0509174A/pt not_active Application Discontinuation
- 2005-03-23 AR ARP050101135A patent/AR048326A1/es unknown
-
2006
- 2006-10-25 ZA ZA200608875A patent/ZA200608875B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005092849A1 (de) | 2005-10-06 |
| JP2007530469A (ja) | 2007-11-01 |
| EP1735279A1 (de) | 2006-12-27 |
| AU2005225489A1 (en) | 2005-10-06 |
| CA2561057A1 (en) | 2005-10-06 |
| BRPI0509174A (pt) | 2007-09-18 |
| AU2005225489B2 (en) | 2011-02-10 |
| RU2006137656A (ru) | 2008-05-10 |
| MXPA06010771A (es) | 2006-12-15 |
| DE102004014945A1 (de) | 2005-10-13 |
| US20070135507A1 (en) | 2007-06-14 |
| CN1938269A (zh) | 2007-03-28 |
| ZA200608875B (en) | 2008-06-25 |
| KR20070010131A (ko) | 2007-01-22 |
| US7683093B2 (en) | 2010-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |