BRPI0509174A - derivados de prolinila para o tratamento de trombose - Google Patents
derivados de prolinila para o tratamento de tromboseInfo
- Publication number
- BRPI0509174A BRPI0509174A BRPI0509174-8A BRPI0509174A BRPI0509174A BR PI0509174 A BRPI0509174 A BR PI0509174A BR PI0509174 A BRPI0509174 A BR PI0509174A BR PI0509174 A BRPI0509174 A BR PI0509174A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- thrombosis
- derivatives
- prolinyl
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
DERIVADOS DE PROLINILA PARA O TRATAMENTO DE TROMBOSE. A presente invenção refere-se a novos compostos da fórmula (1),na qual R, R¬ 1¬, R¬ 2¬, R¬ 3¬ e R¬ 4¬ têm o significado indicado na Reivindicação de Patente 1 são inibidores do fator de coagulação Xa e podem ser empregados para a profilaxia e/ou terapia de doenças tromboembólicas e para o tratamento de tumores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004014945A DE102004014945A1 (de) | 2004-03-26 | 2004-03-26 | Prolinylderivate |
PCT/EP2005/002306 WO2005092849A1 (de) | 2004-03-26 | 2005-03-04 | Prolinylderivate zur behandlung von thrombose |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509174A true BRPI0509174A (pt) | 2007-09-18 |
Family
ID=34961159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509174-8A BRPI0509174A (pt) | 2004-03-26 | 2005-03-04 | derivados de prolinila para o tratamento de trombose |
Country Status (14)
Country | Link |
---|---|
US (1) | US7683093B2 (pt) |
EP (1) | EP1735279A1 (pt) |
JP (1) | JP2007530469A (pt) |
KR (1) | KR20070010131A (pt) |
CN (1) | CN1938269A (pt) |
AR (1) | AR048326A1 (pt) |
AU (1) | AU2005225489B2 (pt) |
BR (1) | BRPI0509174A (pt) |
CA (1) | CA2561057A1 (pt) |
DE (1) | DE102004014945A1 (pt) |
MX (1) | MXPA06010771A (pt) |
RU (1) | RU2006137656A (pt) |
WO (1) | WO2005092849A1 (pt) |
ZA (1) | ZA200608875B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1809346A (zh) * | 2003-06-18 | 2006-07-26 | 默克专利股份公司 | 作为凝血因子xa和viia的抑制剂用于治疗形成血栓的1-[(4-乙炔基苯基) ]-2-[(苯基)]-吡咯烷-1,2-二酰胺衍生物 |
DE10358814A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | Prolinylarylacetamide |
EP1818330A1 (de) | 2006-02-14 | 2007-08-15 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Prolinamide, deren Herstellung und deren Verwendung als Arzneimittel |
CA2653753C (en) | 2006-05-16 | 2013-09-24 | Boehringer Ingelheim International Gmbh | Substituted prolinamides, production thereof and their use as medicaments |
NZ581438A (en) * | 2007-06-28 | 2011-03-31 | Novartis Ag | Kallikrein 7 modulators |
TWI734702B (zh) * | 2015-10-01 | 2021-08-01 | 美商百歐克斯製藥公司 | 人類血漿激肽釋放酶抑制劑 |
CN110240591A (zh) * | 2018-03-08 | 2019-09-17 | 天津药物研究院有限公司 | 脯氨酸衍生物及其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2196163T3 (es) * | 1995-07-31 | 2003-12-16 | Shionogi & Co | Derivados de pirrolidina con una actividad de inhibicion de la fosfolipasa a2. |
EP1185512A2 (en) * | 1999-05-24 | 2002-03-13 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
US6673817B1 (en) * | 1999-05-24 | 2004-01-06 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
US7312235B2 (en) * | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
-
2004
- 2004-03-26 DE DE102004014945A patent/DE102004014945A1/de not_active Withdrawn
-
2005
- 2005-03-04 RU RU2006137656/04A patent/RU2006137656A/ru unknown
- 2005-03-04 WO PCT/EP2005/002306 patent/WO2005092849A1/de active Application Filing
- 2005-03-04 AU AU2005225489A patent/AU2005225489B2/en not_active Ceased
- 2005-03-04 CA CA002561057A patent/CA2561057A1/en not_active Abandoned
- 2005-03-04 MX MXPA06010771A patent/MXPA06010771A/es not_active Application Discontinuation
- 2005-03-04 BR BRPI0509174-8A patent/BRPI0509174A/pt not_active Application Discontinuation
- 2005-03-04 KR KR1020067019772A patent/KR20070010131A/ko not_active Application Discontinuation
- 2005-03-04 US US10/594,024 patent/US7683093B2/en not_active Expired - Fee Related
- 2005-03-04 JP JP2007504284A patent/JP2007530469A/ja active Pending
- 2005-03-04 EP EP05715737A patent/EP1735279A1/de not_active Withdrawn
- 2005-03-04 CN CNA200580009735XA patent/CN1938269A/zh active Pending
- 2005-03-23 AR ARP050101135A patent/AR048326A1/es unknown
-
2006
- 2006-10-25 ZA ZA200608875A patent/ZA200608875B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR048326A1 (es) | 2006-04-19 |
DE102004014945A1 (de) | 2005-10-13 |
CA2561057A1 (en) | 2005-10-06 |
ZA200608875B (en) | 2008-06-25 |
KR20070010131A (ko) | 2007-01-22 |
JP2007530469A (ja) | 2007-11-01 |
AU2005225489B2 (en) | 2011-02-10 |
US20070135507A1 (en) | 2007-06-14 |
MXPA06010771A (es) | 2006-12-15 |
CN1938269A (zh) | 2007-03-28 |
WO2005092849A1 (de) | 2005-10-06 |
EP1735279A1 (de) | 2006-12-27 |
RU2006137656A (ru) | 2008-05-10 |
US7683093B2 (en) | 2010-03-23 |
AU2005225489A1 (en) | 2005-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |