BR0213680A - Derivados de fenoxi-n-'4-(1,1-dioxoisotiazolidin-2-il) fenil-valeramida e outros compostos como inibidores de fator de coagulação xa para o tratamento de doenças tromboembólicas e tumores - Google Patents

Derivados de fenoxi-n-'4-(1,1-dioxoisotiazolidin-2-il) fenil-valeramida e outros compostos como inibidores de fator de coagulação xa para o tratamento de doenças tromboembólicas e tumores

Info

Publication number
BR0213680A
BR0213680A BR0213680-5A BR0213680A BR0213680A BR 0213680 A BR0213680 A BR 0213680A BR 0213680 A BR0213680 A BR 0213680A BR 0213680 A BR0213680 A BR 0213680A
Authority
BR
Brazil
Prior art keywords
tumors
treatment
compounds
coagulation factor
phenoxy
Prior art date
Application number
BR0213680-5A
Other languages
English (en)
Inventor
Dieter Dorsch
Bertram Cezanne
Christos Tsaklakidis
Werner Mederski
Johannes Gleitz
Christopher Barnes
Original Assignee
Merck Patent Ges Mit Beschaenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschaenk filed Critical Merck Patent Ges Mit Beschaenk
Publication of BR0213680A publication Critical patent/BR0213680A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

"DERIVADOS DE FENóXI-N-<39>4-(1,1-DIOXOISOTIAZOLIDIN-2-IL) FENIL-VALERAMIDA E OUTROS COMPOSTOS COMO INIBIDORES DE FATOR DE COAGULAçãO XA PARA O TRATAMENTO DE DOENçAS TROMBOEMBóLICAS E TUMORES". A presente invenção refere-se a novos compostos da fórmula (I), onde D, W, X, Y, T e R^ 1^ são como definidos na reivindicação de patente 1, são inibidores de fator de coagulação Xa e podem ser empregados para a profilaxia e/ou terapia de doenças tromboembólicas e para o tratamento de tumores.
BR0213680-5A 2001-11-09 2002-10-10 Derivados de fenoxi-n-'4-(1,1-dioxoisotiazolidin-2-il) fenil-valeramida e outros compostos como inibidores de fator de coagulação xa para o tratamento de doenças tromboembólicas e tumores BR0213680A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10155075A DE10155075A1 (de) 2001-11-09 2001-11-09 Cyclische Sulfonamide
PCT/EP2002/011349 WO2003039543A1 (de) 2001-11-09 2002-10-10 Derivate des phenoxy-n-'4-(isothiazolidin-1,1-dioxid-2yl)pheny!-valerian-säureamids und andere verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen und tumoren

Publications (1)

Publication Number Publication Date
BR0213680A true BR0213680A (pt) 2004-10-26

Family

ID=7705183

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213680-5A BR0213680A (pt) 2001-11-09 2002-10-10 Derivados de fenoxi-n-'4-(1,1-dioxoisotiazolidin-2-il) fenil-valeramida e outros compostos como inibidores de fator de coagulação xa para o tratamento de doenças tromboembólicas e tumores

Country Status (21)

Country Link
US (1) US7199133B2 (pt)
EP (1) EP1441726B1 (pt)
JP (1) JP4447909B2 (pt)
KR (1) KR20050035165A (pt)
CN (1) CN1582148A (pt)
AR (1) AR037342A1 (pt)
AT (1) ATE348611T1 (pt)
AU (1) AU2002363366B2 (pt)
BR (1) BR0213680A (pt)
CA (1) CA2465713A1 (pt)
DE (2) DE10155075A1 (pt)
DK (1) DK1441726T3 (pt)
ES (1) ES2277623T3 (pt)
HU (1) HUP0401983A2 (pt)
MX (1) MXPA04004307A (pt)
MY (1) MY134079A (pt)
PL (1) PL369737A1 (pt)
PT (1) PT1441726E (pt)
RU (1) RU2301228C2 (pt)
WO (1) WO2003039543A1 (pt)
ZA (1) ZA200404549B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302462A4 (en) * 2000-07-17 2007-07-18 Takeda Pharmaceutical Sulphonic derivatives, process for their preparation and their use
US20040152741A1 (en) * 2002-09-09 2004-08-05 Nps Allelix Corporation Arylglycine derivatives and their use as glycine transport inhibitors
AU2003284596A1 (en) * 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Imidazole derivative, process for producing the same, and use
US7371743B2 (en) * 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
DE102004054847A1 (de) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
KR101009594B1 (ko) * 2007-05-09 2011-01-20 주식회사 레고켐 바이오사이언스 Ｐ4 위치에 사이클릭 아미딘을 가지는 ＦＸａ 저해제, 이의유도체, 제조방법 및 이를 함유하는 의약 조성물
HUE052423T2 (hu) * 2007-09-28 2021-04-28 Alexion Pharma Inc Az XA faktor inhibitorok antidótumai és ezek alkalmazási módszerei
CA2890002A1 (en) 2012-11-05 2014-05-08 Nant Holdings Ip, Llc Cyclic sulfonamide containing derivatives as inhibitors of hedgehog signaling pathway

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Publication number Priority date Publication date Assignee Title
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
US5300523A (en) 1988-07-28 1994-04-05 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
EP0655996B1 (en) * 1992-08-19 2001-11-07 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
US5550139A (en) 1994-01-03 1996-08-27 The Wichita State University Serine protease inhibitors
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
US6489300B1 (en) 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
AR016133A1 (es) * 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
DE19754573A1 (de) * 1997-12-09 1999-06-10 Bayer Ag Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma
DE19804085A1 (de) * 1998-02-03 1999-08-05 Boehringer Ingelheim Pharma 5-Gliedrige heterocyclische kondensierte Benzoderivate, deren Herstellung und deren Verwendung als Arzneimittel
US6114532A (en) 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
SK287238B6 (sk) * 1999-03-17 2010-04-07 Astrazeneca Ab Amidové deriváty, spôsob ich prípravy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie
WO2001055146A1 (en) * 2000-01-29 2001-08-02 Lg Chem Investment Ltd. FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
DE60138635D1 (de) 2000-10-12 2009-06-18 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
US6488154B1 (en) * 2000-10-16 2002-12-03 Ming-Chuan Yeh Chip tray

Also Published As

Publication number Publication date
CN1582148A (zh) 2005-02-16
RU2301228C2 (ru) 2007-06-20
CA2465713A1 (en) 2003-05-15
EP1441726A1 (de) 2004-08-04
US20040254175A1 (en) 2004-12-16
US7199133B2 (en) 2007-04-03
JP2005522412A (ja) 2005-07-28
DK1441726T3 (da) 2007-04-10
MXPA04004307A (es) 2004-08-11
KR20050035165A (ko) 2005-04-15
ES2277623T3 (es) 2007-07-16
AR037342A1 (es) 2004-11-03
ATE348611T1 (de) 2007-01-15
RU2004117594A (ru) 2006-01-10
AU2002363366B2 (en) 2007-11-22
JP4447909B2 (ja) 2010-04-07
ZA200404549B (en) 2005-02-04
DE10155075A1 (de) 2003-05-22
MY134079A (en) 2007-11-30
PT1441726E (pt) 2007-03-30
PL369737A1 (en) 2005-05-02
DE50209031D1 (de) 2007-02-01
WO2003039543A1 (de) 2003-05-15
EP1441726B1 (de) 2006-12-20
HUP0401983A2 (hu) 2005-01-28

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.