ATE538796T1 - Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit - Google Patents
Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheitInfo
- Publication number
- ATE538796T1 ATE538796T1 AT07838507T AT07838507T ATE538796T1 AT E538796 T1 ATE538796 T1 AT E538796T1 AT 07838507 T AT07838507 T AT 07838507T AT 07838507 T AT07838507 T AT 07838507T AT E538796 T1 ATE538796 T1 AT E538796T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- treatment
- alzheimer
- disease
- pyrrolidine
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- 239000002439 beta secretase inhibitor Substances 0.000 title 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 3
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84640006P | 2006-09-21 | 2006-09-21 | |
| PCT/US2007/020303 WO2008036316A2 (en) | 2006-09-21 | 2007-09-19 | Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538796T1 true ATE538796T1 (de) | 2012-01-15 |
Family
ID=39201073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07838507T ATE538796T1 (de) | 2006-09-21 | 2007-09-19 | Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8143405B2 (de) |
| EP (1) | EP2077719B1 (de) |
| JP (1) | JP2010504330A (de) |
| AT (1) | ATE538796T1 (de) |
| AU (1) | AU2007297627A1 (de) |
| CA (1) | CA2664130A1 (de) |
| WO (1) | WO2008036316A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010002938A (es) | 2007-09-24 | 2010-04-01 | Comentis Inc | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
| CA2703915C (en) * | 2007-10-31 | 2015-02-24 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| EP2349244A4 (de) * | 2008-10-10 | 2012-09-19 | Comentis Inc | Bicyclische verbindungen zur hemmung der beta-sekretase-aktivität und verwendungsverfahren dafür |
| US20120214802A1 (en) * | 2009-03-25 | 2012-08-23 | Bilcer Geoffrey M | Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| US11512072B2 (en) | 2018-04-19 | 2022-11-29 | University Of Virginia Patent Foundation | Compositions and methods for preparing and using azetidines |
| JP2023546996A (ja) * | 2020-10-23 | 2023-11-08 | ニンバス クロソー， インコーポレイテッド | Ｃｔｐｓ１阻害剤およびその使用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003043987A2 (en) | 2001-11-19 | 2003-05-30 | Elan Pharmaceuticals, Inc. | (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP3897602B2 (ja) * | 2002-01-28 | 2007-03-28 | ヤンマー株式会社 | ガス機関の燃料供給装置 |
| US7115652B2 (en) * | 2002-06-17 | 2006-10-03 | Sunesis Pharmaceuticals, Inc. | Aspartyl protease inhibitors |
| EP1515944A1 (de) | 2002-06-17 | 2005-03-23 | Sunesis Pharmaceuticals, Inc. | Aspartyl-protease inhibitoren |
| ATE443043T1 (de) * | 2002-11-12 | 2009-10-15 | Merck & Co Inc | Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer |
| US7166624B2 (en) * | 2002-12-18 | 2007-01-23 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| WO2004101512A2 (en) * | 2003-05-13 | 2004-11-25 | Smithkline Beecham Corporation | Naphthyridine integrase inhibitors |
| EP1641748B1 (de) * | 2003-06-30 | 2013-08-28 | Merck Sharp & Dohme Corp. | N-alkylphenylcarboxamid-beta-secretase-hemmer zur behandlung von alzheimer-krankheit |
| US7348448B2 (en) * | 2003-07-01 | 2008-03-25 | Merck & Co., Inc. | Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease |
| CN1859904A (zh) * | 2003-10-03 | 2006-11-08 | 默克公司 | 用于治疗阿尔茨海默氏病的苄醚和苄氨基β－分泌酶抑制剂 |
| JP4576386B2 (ja) * | 2003-11-24 | 2010-11-04 | メルク・シャープ・エンド・ドーム・コーポレイション | アルツハイマー病治療用のベンジルエーテルおよびベンジルアミノ系β−セクレターゼ阻害薬 |
| AU2004311749A1 (en) * | 2003-12-19 | 2005-07-21 | Merck & Co., Inc. | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
| JP2007533743A (ja) | 2004-04-20 | 2007-11-22 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病治療のためのβ−セクレターゼ阻害薬として有用な１，３，５−置換フェニル誘導体化合物 |
| EP1740581B1 (de) | 2004-04-20 | 2012-08-22 | Merck Sharp & Dohme Corp. | Beta-sekretase-inhibitoren für die behandlung von alzheimer-krankheit geeignete 2,4,6-substituierte pyridylderivatverbindungen |
| EP1758854B1 (de) * | 2004-06-15 | 2014-07-16 | Merck Sharp & Dohme Corp. | Als beta-sekretase-inhibitoren für die behandlung von alzheimer-krankheit geeignete pyrrolidin-3-yl-verbindungen |
| US20070060589A1 (en) * | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
| JP2009530383A (ja) * | 2006-03-21 | 2009-08-27 | シェーリング コーポレイション | Ｃｘｃｒ３拮抗活性を有する、新規ヘテロ環ピリジン置換体 |
| WO2008011130A2 (en) * | 2006-07-21 | 2008-01-24 | Takeda Pharmaceutical Company Limited | Amide compounds |
-
2007
- 2007-09-19 EP EP07838507A patent/EP2077719B1/de not_active Not-in-force
- 2007-09-19 AU AU2007297627A patent/AU2007297627A1/en not_active Abandoned
- 2007-09-19 JP JP2009529223A patent/JP2010504330A/ja not_active Withdrawn
- 2007-09-19 US US12/311,158 patent/US8143405B2/en active Active
- 2007-09-19 CA CA002664130A patent/CA2664130A1/en not_active Abandoned
- 2007-09-19 WO PCT/US2007/020303 patent/WO2008036316A2/en not_active Ceased
- 2007-09-19 AT AT07838507T patent/ATE538796T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008036316A2 (en) | 2008-03-27 |
| CA2664130A1 (en) | 2008-03-27 |
| EP2077719B1 (de) | 2011-12-28 |
| WO2008036316A3 (en) | 2008-11-06 |
| JP2010504330A (ja) | 2010-02-12 |
| US20100041667A1 (en) | 2010-02-18 |
| EP2077719A2 (de) | 2009-07-15 |
| AU2007297627A1 (en) | 2008-03-27 |
| US8143405B2 (en) | 2012-03-27 |
| EP2077719A4 (de) | 2010-12-08 |
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