EA200870380A1 - Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-vi для лечения или предупреждения диабета - Google Patents

Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-vi для лечения или предупреждения диабета

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Publication number
EA200870380A1
EA200870380A1 EA200870380A EA200870380A EA200870380A1 EA 200870380 A1 EA200870380 A1 EA 200870380A1 EA 200870380 A EA200870380 A EA 200870380A EA 200870380 A EA200870380 A EA 200870380A EA 200870380 A1 EA200870380 A1 EA 200870380A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diabetes
inhibitors
prevention
treatment
enzyme
Prior art date
Application number
EA200870380A
Other languages
English (en)
Inventor
Тесфайе Бифту
Энн Е. Вебер
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200870380A1 publication Critical patent/EA200870380A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Настоящее изобретение направлено на создание новых замещенных аминотетрагидропиранов структурной формулы (I), которые являются ингибиторами фермента дипептидилпептидазы-IV и которые можно использовать для лечения или предупреждения заболеваний, в которые вовлечен фермент ипептидилпептидаза-IV, таких как диабет и особенно диабет типа 2. Изобретение также направлено на создание фармацевтических композиций, содержащих эти соединения, и их использование для предупреждения или лечения таких заболеваний, в которые вовлечен фермент дипептидилпептидаза-IV.
EA200870380A 2006-03-28 2007-03-26 Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-vi для лечения или предупреждения диабета EA200870380A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78651806P 2006-03-28 2006-03-28
US83812206P 2006-08-16 2006-08-16
PCT/US2007/007434 WO2007126745A2 (en) 2006-03-28 2007-03-26 Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

Publications (1)

Publication Number Publication Date
EA200870380A1 true EA200870380A1 (ru) 2009-02-27

Family

ID=38521359

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870380A EA200870380A1 (ru) 2006-03-28 2007-03-26 Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-vi для лечения или предупреждения диабета

Country Status (22)

Country Link
US (1) US7678905B2 (ru)
EP (1) EP2001883B1 (ru)
JP (1) JP5229706B2 (ru)
KR (1) KR20090005306A (ru)
AR (1) AR059984A1 (ru)
AT (1) ATE554091T1 (ru)
AU (1) AU2007243631B2 (ru)
BR (1) BRPI0709141A2 (ru)
CA (1) CA2646962C (ru)
CR (1) CR10343A (ru)
DO (1) DOP2007000051A (ru)
EA (1) EA200870380A1 (ru)
EC (1) ECSP088765A (ru)
GT (1) GT200800184A (ru)
MA (1) MA30333B1 (ru)
MX (1) MX2008012490A (ru)
NO (1) NO20084508L (ru)
PE (1) PE20071104A1 (ru)
SV (1) SV2008003045A (ru)
TN (1) TNSN08367A1 (ru)
TW (1) TW200806669A (ru)
WO (1) WO2007126745A2 (ru)

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RU2550508C2 (ru) * 2009-09-02 2015-05-10 Мерк Шарп И Доум Корп. Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-iv для лечения или предупреждения диабета
RU2702644C2 (ru) * 2014-10-31 2019-10-09 Ист Чайна Юниверсити Оф Сайенс Энд Текнолоджи Бензопроизводные с шестичленным кольцом в качестве ингибитора dpp-4 и их применение
RU2720488C2 (ru) * 2015-02-12 2020-04-30 Центаурус Биофарма Ко., Лтд. Замещенные амино шестичленные насыщенные гетероалициклы в качестве ингибиторов dpp-iv длительного действия

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EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
CN103987388A (zh) 2011-06-29 2014-08-13 默沙东公司 二肽基肽酶-iv抑制剂的新晶形
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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RU2550508C2 (ru) * 2009-09-02 2015-05-10 Мерк Шарп И Доум Корп. Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-iv для лечения или предупреждения диабета
RU2702644C2 (ru) * 2014-10-31 2019-10-09 Ист Чайна Юниверсити Оф Сайенс Энд Текнолоджи Бензопроизводные с шестичленным кольцом в качестве ингибитора dpp-4 и их применение
US10479798B2 (en) 2014-10-31 2019-11-19 East China University Of Science And Technology Six-membered ring benzo derivatives as DPP-4 inhibitor and use thereof
RU2720488C2 (ru) * 2015-02-12 2020-04-30 Центаурус Биофарма Ко., Лтд. Замещенные амино шестичленные насыщенные гетероалициклы в качестве ингибиторов dpp-iv длительного действия

Also Published As

Publication number Publication date
MA30333B1 (fr) 2009-04-01
JP5229706B2 (ja) 2013-07-03
TNSN08367A1 (en) 2009-12-29
US20070232676A1 (en) 2007-10-04
NO20084508L (no) 2008-10-27
ATE554091T1 (de) 2012-05-15
CA2646962A1 (en) 2007-11-08
EP2001883B1 (en) 2012-04-18
GT200800184A (es) 2011-09-05
AU2007243631A1 (en) 2007-11-08
EP2001883A2 (en) 2008-12-17
DOP2007000051A (es) 2007-12-15
CA2646962C (en) 2011-06-21
KR20090005306A (ko) 2009-01-13
ECSP088765A (es) 2008-10-31
CR10343A (es) 2008-10-29
WO2007126745A3 (en) 2007-12-21
AU2007243631B2 (en) 2011-11-24
MX2008012490A (es) 2008-10-10
SV2008003045A (es) 2009-11-09
TW200806669A (en) 2008-02-01
WO2007126745A2 (en) 2007-11-08
PE20071104A1 (es) 2007-12-29
BRPI0709141A2 (pt) 2011-06-28
JP2009531437A (ja) 2009-09-03
US7678905B2 (en) 2010-03-16
AR059984A1 (es) 2008-05-14

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