ATE538651T1 - Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit - Google Patents

Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit

Info

Publication number
ATE538651T1
ATE538651T1 AT07853004T AT07853004T ATE538651T1 AT E538651 T1 ATE538651 T1 AT E538651T1 AT 07853004 T AT07853004 T AT 07853004T AT 07853004 T AT07853004 T AT 07853004T AT E538651 T1 ATE538651 T1 AT E538651T1
Authority
AT
Austria
Prior art keywords
beta
treatment
alzheimer
inhibitors
disease
Prior art date
Application number
AT07853004T
Other languages
English (en)
Inventor
Shaun Stauffer
Ivory Hills
Ashley Nomland
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE538651T1 publication Critical patent/ATE538651T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT07853004T 2006-10-30 2007-10-29 Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit ATE538651T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85518006P 2006-10-30 2006-10-30
PCT/US2007/022819 WO2008054698A2 (en) 2006-10-30 2007-10-29 Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
ATE538651T1 true ATE538651T1 (de) 2012-01-15

Family

ID=39344862

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07853004T ATE538651T1 (de) 2006-10-30 2007-10-29 Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit

Country Status (7)

Country Link
US (1) US8293759B2 (de)
EP (1) EP2091328B1 (de)
JP (1) JP2010508272A (de)
AT (1) ATE538651T1 (de)
AU (1) AU2007314338A1 (de)
CA (1) CA2668065A1 (de)
WO (1) WO2008054698A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2091328B1 (de) 2006-10-30 2011-12-28 Merck Sharp & Dohme Corp. Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
US8377954B2 (en) 2007-01-04 2013-02-19 Merck, Sharp & Dohme, Corp Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
US8426447B2 (en) 2008-09-11 2013-04-23 Amgen Inc. Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use
PE20110777A1 (es) * 2008-11-23 2011-10-29 Pfizer Nuevas lactamas como inhibidores de beta secretasa
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
US8883782B2 (en) 2010-03-15 2014-11-11 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
JP5584352B2 (ja) 2010-03-15 2014-09-03 アムジエン・インコーポレーテツド β−セクレターゼ調節剤としてのアミノ−ジヒドロオキサジン系およびアミノ−ジヒドロチアジン系スピロ化合物ならびにそれらの医学的用途
US8921363B2 (en) 2010-08-05 2014-12-30 Amgen Inc. Derivatives of 1 H-isoindol-3-amine, 1 H-iso-aza-indol-3amine, 3,4-dihydroisoquinolin-1-amine, and 1,4-dihydroisoquinolin-3-amine as beta-secretase inhibitors
EP2643325A1 (de) 2010-11-23 2013-10-02 Amgen Inc. Spiro-amino-imidazolon- und spiro-amino-dihydro-pyrimidinonverbindungen als beta-sekretase-modulatoren und verwendungsverfahren dafür
EP2673279A1 (de) 2011-02-07 2013-12-18 Amgen Inc. 5-amino-oxazepin- und 5-amino-thiazepanverbindungen als beta-sekretase-antagonisten und verwendungsverfahren
US8962859B2 (en) 2011-02-15 2015-02-24 Amgen Inc. Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
WO2013044092A1 (en) 2011-09-21 2013-03-28 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US9725469B2 (en) 2012-11-15 2017-08-08 Amgen, Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN112979537B (zh) * 2021-02-23 2022-04-29 浙江工业大学 一种卡因类药物中间体(s)-2-哌啶甲酸的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5852029A (en) 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
AU4562799A (en) 1998-06-15 2000-01-05 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
NZ571695A (en) 2001-12-28 2010-02-26 Acadia Pharm Inc Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events
MXPA04010921A (es) * 2002-05-03 2005-05-27 Israel Inst Biolog Res Metodos y composiciones para el tratamietno de trastornos del sistema nervioso central y periferico y compuestos novedosos utiles para los mismos.
JP2006512404A (ja) 2002-10-22 2006-04-13 グラクソ　グループ　リミテッド Ｈ３受容体リガンドとしてのアリールオキシアルキルアミン誘導体
US20060116366A1 (en) 2002-12-04 2006-06-01 Parmee Emma R Spirocyclic ureas, compositions containing such compounds and methods of use
CA2583342A1 (en) * 2004-10-13 2006-04-27 Merck And Co., Inc. Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease
WO2007011810A1 (en) 2005-07-18 2007-01-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
CA2627692A1 (en) 2006-01-30 2007-08-02 Irm Llc Spiro imidazole derivatives as ppar modulators
AU2007293416A1 (en) 2006-09-07 2008-03-13 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
AU2007307170A1 (en) 2006-10-06 2008-04-17 Merck & Co., Inc. Macrocyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
EP2091328B1 (de) 2006-10-30 2011-12-28 Merck Sharp & Dohme Corp. Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit

Also Published As

Publication number Publication date
US8293759B2 (en) 2012-10-23
WO2008054698A3 (en) 2008-06-19
WO2008054698A2 (en) 2008-05-08
US20100069419A1 (en) 2010-03-18
EP2091328A2 (de) 2009-08-26
AU2007314338A1 (en) 2008-05-08
EP2091328A4 (de) 2010-11-03
CA2668065A1 (en) 2008-05-08
JP2010508272A (ja) 2010-03-18
EP2091328B1 (de) 2011-12-28

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