ATE512147T1 - Makrozyklische aminiopyridyl-beta-sekretase- hemmer zur behandlung von morbus alzheimer - Google Patents
Makrozyklische aminiopyridyl-beta-sekretase- hemmer zur behandlung von morbus alzheimerInfo
- Publication number
- ATE512147T1 ATE512147T1 AT05849049T AT05849049T ATE512147T1 AT E512147 T1 ATE512147 T1 AT E512147T1 AT 05849049 T AT05849049 T AT 05849049T AT 05849049 T AT05849049 T AT 05849049T AT E512147 T1 ATE512147 T1 AT E512147T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- macrocyclic
- alzheimer
- disease
- aminiopyridyl
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 239000002439 beta secretase inhibitor Substances 0.000 title 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 3
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- -1 aminopyridyl compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63031904P | 2004-11-23 | 2004-11-23 | |
| PCT/US2005/042233 WO2006057983A1 (en) | 2004-11-23 | 2005-11-18 | Macrocyclic aminopyridyl beta-secretase inhibitors for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE512147T1 true ATE512147T1 (de) | 2011-06-15 |
Family
ID=36498305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05849049T ATE512147T1 (de) | 2004-11-23 | 2005-11-18 | Makrozyklische aminiopyridyl-beta-sekretase- hemmer zur behandlung von morbus alzheimer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7951949B2 (de) |
| EP (1) | EP1817312B1 (de) |
| JP (1) | JP2008520727A (de) |
| CN (1) | CN101061119A (de) |
| AT (1) | ATE512147T1 (de) |
| AU (1) | AU2005309708A1 (de) |
| CA (1) | CA2587256A1 (de) |
| WO (1) | WO2006057983A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7678783B2 (en) | 2004-11-17 | 2010-03-16 | Merck Sharp & Dohme Corp. | Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2008045250A1 (en) * | 2006-10-06 | 2008-04-17 | Merck & Co., Inc. | Macrocyclic spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| NZ598685A (en) | 2009-09-11 | 2013-05-31 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (de) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Hemmer der glutaminylzyklase |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| CN104263795A (zh) * | 2014-08-22 | 2015-01-07 | 四川同晟生物科技有限公司 | 制备手性α-环烷基甘氨酸的方法 |
| EP3461819B1 (de) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Hemmer der glutaminylcyclase |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6525074B2 (en) * | 2000-01-12 | 2003-02-25 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| JP2005505506A (ja) | 2001-06-12 | 2005-02-24 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病の治療に有用な大環状分子 |
| CA2489095A1 (en) | 2002-06-17 | 2003-12-24 | Sunesis Pharmaceuticals, Inc. | Aspartyl protease inhibitors |
| CA2505098A1 (en) * | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2004062625A2 (en) * | 2003-01-07 | 2004-07-29 | Merck & Co., Inc. | Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease |
| AU2003297826A1 (en) | 2003-06-16 | 2005-01-28 | Sunesis Pharmaceuticals, Inc | Aspartyl protease inhibitors |
| US7291620B2 (en) * | 2003-06-30 | 2007-11-06 | Merck + Co., Inc. | N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
| EP1643986A4 (de) * | 2003-07-01 | 2009-04-08 | Merck & Co Inc | Phenylcarboxylat-beta-secretase-hemmer zur behandlung von morbus alzheimer |
| US7329746B2 (en) * | 2003-08-14 | 2008-02-12 | Merck & Co., Inc. | Macrocyclic beta-secretase inhibitors for the treatment of Alzheimer's disease |
| CN1859904A (zh) * | 2003-10-03 | 2006-11-08 | 默克公司 | 用于治疗阿尔茨海默氏病的苄醚和苄氨基β－分泌酶抑制剂 |
| US7354942B2 (en) | 2003-11-24 | 2008-04-08 | Merck & Co., Inc. | Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease |
| CN100537523C (zh) | 2003-12-19 | 2009-09-09 | 默克公司 | 用于治疗阿尔茨海默病的苯基酰胺和吡啶基酰胺类β-分泌酶抑制剂 |
| CA2563615A1 (en) | 2004-04-20 | 2005-11-03 | Merck & Co., Inc. | 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP4764418B2 (ja) | 2004-04-20 | 2011-09-07 | メルク・シャープ・エンド・ドーム・コーポレイション | アルツハイマー病の治療のためのβ−セクレターゼ阻害剤として有用な２，４，６−置換ピリジル誘導体化合物 |
| DE602004010314T2 (de) * | 2004-08-09 | 2009-03-05 | Cellzome Ag | Behandlung von neurodegenerativen erkrankungen durch verwendung von degs-inhibitoren |
| US7678783B2 (en) | 2004-11-17 | 2010-03-16 | Merck Sharp & Dohme Corp. | Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease |
-
2005
- 2005-11-18 AT AT05849049T patent/ATE512147T1/de not_active IP Right Cessation
- 2005-11-18 EP EP05849049A patent/EP1817312B1/de not_active Expired - Lifetime
- 2005-11-18 WO PCT/US2005/042233 patent/WO2006057983A1/en not_active Ceased
- 2005-11-18 AU AU2005309708A patent/AU2005309708A1/en not_active Abandoned
- 2005-11-18 US US11/791,465 patent/US7951949B2/en active Active
- 2005-11-18 JP JP2007543382A patent/JP2008520727A/ja active Pending
- 2005-11-18 CA CA002587256A patent/CA2587256A1/en not_active Abandoned
- 2005-11-18 CN CNA2005800399218A patent/CN101061119A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101061119A (zh) | 2007-10-24 |
| CA2587256A1 (en) | 2006-06-01 |
| WO2006057983A1 (en) | 2006-06-01 |
| EP1817312B1 (de) | 2011-06-08 |
| EP1817312A1 (de) | 2007-08-15 |
| JP2008520727A (ja) | 2008-06-19 |
| AU2005309708A1 (en) | 2006-06-01 |
| US20080015213A1 (en) | 2008-01-17 |
| US7951949B2 (en) | 2011-05-31 |
| EP1817312A4 (de) | 2009-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |