ATE555116T1 - Ahcy-hydrolasehemmer zur behandlung von hyperhomocysteinämie - Google Patents
Ahcy-hydrolasehemmer zur behandlung von hyperhomocysteinämieInfo
- Publication number
- ATE555116T1 ATE555116T1 AT09714617T AT09714617T ATE555116T1 AT E555116 T1 ATE555116 T1 AT E555116T1 AT 09714617 T AT09714617 T AT 09714617T AT 09714617 T AT09714617 T AT 09714617T AT E555116 T1 ATE555116 T1 AT E555116T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- ahcy
- hyperhomocysteinemia
- hydrolase inhibitors
- inhibitors
- Prior art date
Links
- 102100020925 Adenosylhomocysteinase Human genes 0.000 title abstract 2
- 101000716952 Homo sapiens Adenosylhomocysteinase Proteins 0.000 title abstract 2
- 208000033892 Hyperhomocysteinemia Diseases 0.000 title 1
- 239000004093 hydrolase inhibitor Substances 0.000 title 1
- 230000003225 hyperhomocysteinemia Effects 0.000 title 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6721008P | 2008-02-26 | 2008-02-26 | |
| PCT/US2009/034344 WO2009108546A1 (en) | 2008-02-26 | 2009-02-18 | Ahcy hydrolase inhibitors for treatment of hyper homocysteinemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555116T1 true ATE555116T1 (de) | 2012-05-15 |
Family
ID=41016437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09714617T ATE555116T1 (de) | 2008-02-26 | 2009-02-18 | Ahcy-hydrolasehemmer zur behandlung von hyperhomocysteinämie |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8329697B2 (de) |
| EP (1) | EP2257161B1 (de) |
| AT (1) | ATE555116T1 (de) |
| WO (1) | WO2009108546A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329697B2 (en) * | 2008-02-26 | 2012-12-11 | Merck Sharp & Dohme Corp. | Imidizo[1,2-A]pyrazines useful as AHCY hydrolase inhibitors |
| EP2486925A4 (de) * | 2009-10-09 | 2014-03-19 | Mitsubishi Tanabe Pharma Corp | Therapeutikum für ischämischen schlaganfall |
| JP5641664B2 (ja) | 2009-10-30 | 2014-12-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | イミダゾ［１，２−ｂ］ピリダジン誘導体およびＰＤＥ１０阻害剤としてのそれらの使用 |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
| AU2013283426B2 (en) | 2012-06-26 | 2018-02-22 | Janssen Pharmaceutica Nv | Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| WO2014009305A1 (en) | 2012-07-09 | 2014-01-16 | Janssen Pharmaceutica Nv | Inhibitors of phosphodiesterase 10 enzyme |
| WO2017123058A1 (en) | 2016-01-14 | 2017-07-20 | Handok Inc. | Compounds antagonizing a3 adenosine receptor, method for preparing them, and medical-use thereof |
| IL295978B2 (en) | 2017-10-18 | 2024-01-01 | Incyte Corp | Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-gamma inhibitors |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| CN116840197A (zh) * | 2022-03-23 | 2023-10-03 | 中国科学院苏州生物医学工程技术研究所 | 一种2’-o-甲基转移酶活性检测方法、试剂盒及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507294A (en) * | 1982-03-08 | 1985-03-26 | Schering Corp. | Imidazo[1,2-a]pyrazines |
| US5521162A (en) * | 1987-08-26 | 1996-05-28 | Merrell Pharmaceuticals Inc. | Aristeromycin analogues of 4',5'-didehydro-5'-fluoro-adenosine and methods of treating neoplastic and viral disease conditions |
| US7208495B2 (en) * | 2001-07-05 | 2007-04-24 | Takeda Pharmaceutical Company Limited | Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof |
| US7196093B2 (en) * | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
| US8329697B2 (en) * | 2008-02-26 | 2012-12-11 | Merck Sharp & Dohme Corp. | Imidizo[1,2-A]pyrazines useful as AHCY hydrolase inhibitors |
-
2009
- 2009-02-18 US US12/811,911 patent/US8329697B2/en not_active Expired - Fee Related
- 2009-02-18 EP EP09714617A patent/EP2257161B1/de not_active Not-in-force
- 2009-02-18 WO PCT/US2009/034344 patent/WO2009108546A1/en not_active Ceased
- 2009-02-18 AT AT09714617T patent/ATE555116T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100305135A1 (en) | 2010-12-02 |
| US8329697B2 (en) | 2012-12-11 |
| EP2257161B1 (de) | 2012-04-25 |
| EP2257161A1 (de) | 2010-12-08 |
| WO2009108546A1 (en) | 2009-09-03 |
| EP2257161A4 (de) | 2011-03-16 |
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