CY1111086T1 - Παραγωγα 2-αμινο-κιναζολινης χρησιμα ως αναστολεις της βητα-σεκρετασης (bace) - Google Patents
Παραγωγα 2-αμινο-κιναζολινης χρησιμα ως αναστολεις της βητα-σεκρετασης (bace)Info
- Publication number
- CY1111086T1 CY1111086T1 CY20111100022T CY111100022T CY1111086T1 CY 1111086 T1 CY1111086 T1 CY 1111086T1 CY 20111100022 T CY20111100022 T CY 20111100022T CY 111100022 T CY111100022 T CY 111100022T CY 1111086 T1 CY1111086 T1 CY 1111086T1
- Authority
- CY
- Cyprus
- Prior art keywords
- beta
- bace
- inhibitors
- amino
- secretarise
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Abstract
Η παρούσα εφεύρεση αναφέρεται σε καινούργια παράγωγα του 2-amino-3, 4-dihydroquinazoline, φαρμακευτικές συνθέσεις που τις περιέχουν και τη χρήση τους στην θεραπευτική αντιμετώπιση της νόσου του Alzheimer (AD) και συγγενών παθήσεων. Οι χημικές ενώσεις της εφεύρεσης είναι αναστολείς της P-secretase, επίσης γνωστή ως ένζυμο διχοτόμησης στη θέση-n ή και BACE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59981104P | 2004-08-06 | 2004-08-06 | |
EP05785256A EP1776349B1 (en) | 2004-08-06 | 2005-08-08 | 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (bace) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111086T1 true CY1111086T1 (el) | 2015-06-11 |
Family
ID=35564387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100022T CY1111086T1 (el) | 2004-08-06 | 2011-01-04 | Παραγωγα 2-αμινο-κιναζολινης χρησιμα ως αναστολεις της βητα-σεκρετασης (bace) |
Country Status (15)
Country | Link |
---|---|
US (1) | US8436006B2 (el) |
EP (1) | EP1776349B1 (el) |
JP (1) | JP4884387B2 (el) |
CN (1) | CN101035771A (el) |
AT (1) | ATE483692T1 (el) |
CY (1) | CY1111086T1 (el) |
DE (1) | DE602005024004D1 (el) |
DK (1) | DK1776349T3 (el) |
ES (1) | ES2351667T3 (el) |
HR (1) | HRP20100595T1 (el) |
PL (1) | PL1776349T3 (el) |
PT (1) | PT1776349E (el) |
RS (1) | RS51630B (el) |
SI (1) | SI1776349T1 (el) |
WO (1) | WO2006017836A2 (el) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US8383637B2 (en) * | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8426429B2 (en) * | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8436006B2 (en) | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
ES2436795T3 (es) | 2005-06-14 | 2014-01-07 | Merck Sharp & Dohme Corp. | Inhibidores heterocíclicos de aspartil proteasa, preparación y uso de los mismos |
AU2006259572A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
WO2007050612A1 (en) * | 2005-10-25 | 2007-05-03 | Janssen Pharmaceutica N.V. | 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (bace) |
US7868022B2 (en) | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
US7932261B2 (en) * | 2006-02-06 | 2011-04-26 | Janssen Pharmaceutica Nv | Macrocycle derivatives useful as inhibitors of β-secretase (BACE) |
US7776882B2 (en) * | 2006-02-06 | 2010-08-17 | Baxter Ellen W | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
AU2007258435A1 (en) | 2006-06-12 | 2007-12-21 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
CN101668751A (zh) | 2006-12-12 | 2010-03-10 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
EP2164834A2 (en) | 2007-07-06 | 2010-03-24 | Boehringer Ingelheim International GmbH | Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture |
EP2205596A1 (en) * | 2007-09-24 | 2010-07-14 | Comentis, Inc. | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
US8115031B2 (en) * | 2007-11-09 | 2012-02-14 | Yates Charles R | Anti-inflammatory quinic acid derivatives for oral administration |
EP2238111B1 (en) * | 2008-01-28 | 2013-01-16 | Janssen Pharmaceutica NV | 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of -secretase (bace) |
BRPI0907061A2 (pt) * | 2008-01-29 | 2015-07-07 | Janssen Pharmaceutica Nv | Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base) |
CL2009000953A1 (es) | 2008-04-22 | 2010-12-31 | Schering Corp | Compuestos derivados de 2-imino-3-metil-pirrolo pirimidinona, composicion farmaceutica, util para inhibir la beta-secretasa, destinado al tratamiento de la enfermedad de alzheimer, sindrome de down, parkinson, perdida de la memoria, demencia, accidente cerebrovascular, microgliosis e inflamacion cerebral, glaucoma amiloidosis, diabetes tipo ii, entre otras. |
EP2349308A4 (en) * | 2008-10-10 | 2012-09-12 | Purdue Research Foundation | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
EP2376083A4 (en) * | 2008-11-20 | 2012-06-20 | Purdue Research Foundation | CHINAZOLIN INHIBITORS OF BACE 1 AND METHOD OF USE |
WO2010065861A2 (en) | 2008-12-05 | 2010-06-10 | Purdue Research Foundation | Inhibitors of bace 1 and methods for treating alzheimer's disease |
US9296698B2 (en) | 2009-11-23 | 2016-03-29 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
CA2832473A1 (en) * | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 5-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions, and their use |
CN103596939A (zh) * | 2011-04-13 | 2014-02-19 | 默沙东公司 | 作为bace抑制剂的5-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其应用 |
WO2013148130A1 (en) * | 2012-03-29 | 2013-10-03 | Oklahoma Medical Research Foundation | Inhibition of memapsin 1 cleavage in the treatment of diabetes |
EP2958901B1 (de) | 2013-02-25 | 2016-11-02 | Merck Patent GmbH | 2-amino-3,4-dihydro-chinazolin derivate und ihre verwendung als cathepsin d inhibitoren |
CA3087856A1 (en) | 2018-01-10 | 2019-07-18 | Cura Therapeutics, Llc | Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3138595A (en) * | 1962-12-03 | 1964-06-23 | American Home Prod | Nu-(cycloalkyl)-pteridinecarboxamides |
US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
US3983120A (en) * | 1974-11-06 | 1976-09-28 | Bristol-Myers Company | Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
US3988340A (en) * | 1975-01-23 | 1976-10-26 | Bristol-Myers Company | 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones |
US4001237A (en) * | 1976-02-18 | 1977-01-04 | Bristol-Myers Company | Oxazole, isoxazole, thiazole and isothiazole amides |
NL7807507A (nl) * | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
ZA803535B (en) | 1979-06-20 | 1981-06-24 | Hoffmann La Roche | Novel quinazoline derivatives and pharmaceutical preparations |
CA1131631A (en) | 1979-06-20 | 1982-09-14 | Madhukar S. Chodnekar | Quinazoline derivatives and pharmaceutical preparations |
NZ197420A (en) * | 1980-07-01 | 1984-04-27 | Ici Australia Ltd | -(quinazolin-(2-or 4-)(oxy,ylthio or amino)phen(oxy or ylthio)alkanoic acid derivatives |
JPS57123184A (en) | 1980-12-16 | 1982-07-31 | Hoffmann La Roche | Novel manufacture of imidazoquinazolinone derivative |
US4455311A (en) * | 1981-08-28 | 1984-06-19 | Hoffmann-La Roche Inc. | Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system |
ZA826088B (en) | 1981-08-28 | 1983-04-27 | Hoffmann La Roche | Novel imidazoquinazoline derivatives |
JPS6028979A (ja) | 1983-07-14 | 1985-02-14 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン類化合物 |
US5684153A (en) * | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
US4783467A (en) * | 1985-06-05 | 1988-11-08 | Pfizer Inc. | Tetrahydroimidazoquinazolinone inotropic agents |
GB8514207D0 (en) | 1985-06-05 | 1985-07-10 | Pfizer Ltd | Cardiac stimulants |
US4761416A (en) * | 1986-07-25 | 1988-08-02 | Syntex (U.S.A.) Inc. | N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds |
US4739056A (en) * | 1986-11-26 | 1988-04-19 | Syntex (U.S.A.) Inc. | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds |
JPH0730046B2 (ja) | 1987-02-10 | 1995-04-05 | 第一製薬株式会社 | キナゾリン酢酸誘導体 |
JP2544939B2 (ja) | 1987-09-01 | 1996-10-16 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
NZ234186A (en) | 1989-07-07 | 1991-10-25 | Janssen Pharmaceutica Nv | Imidazo quinazolin-one derivatives and pharmaceutical compositions |
JPH06507782A (ja) * | 1990-06-15 | 1994-09-08 | サイオス ノバ インコーポレイテッド | アルツハイマー病のアミロイド形成開症状を示すヒト以外の組換え哺乳動物 |
JPH04112255A (ja) | 1990-09-03 | 1992-04-14 | Casio Comput Co Ltd | ターミナル識別データ設定方式 |
ATE447016T1 (de) * | 1991-01-21 | 2009-11-15 | Elan Pharm Inc | Prüfung und modell für alzheimers-krankheit |
US5672805A (en) * | 1991-07-18 | 1997-09-30 | The Regents Of The University Of California | Transgenic mice expressing the neurotoxic C-terminus of β-amyloid precursor protein |
WO1993007296A1 (en) * | 1991-10-03 | 1993-04-15 | Indiana University Foundation | Method for screening for alzheimer's disease |
ES2204899T3 (es) * | 1992-01-07 | 2004-05-01 | Elan Pharmaceuticals, Inc. | Modelos de animales transgenicos para la enfermedad de alzheimer. |
SE511886C2 (sv) * | 1992-01-31 | 1999-12-13 | Svedala Arbra Ab | Sätt att styra en gyratorisk kross |
US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
US5958883A (en) * | 1992-09-23 | 1999-09-28 | Board Of Regents Of The University Of Washington Office Of Technology | Animal models of human amyloidoses |
DE1001019T1 (de) * | 1993-10-27 | 2001-01-11 | Lilly Co Eli | Transgene Tiere, die APP Allele mit der schwedischen Mutation beherbergen |
JPH07132033A (ja) * | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
US6211428B1 (en) * | 1994-09-01 | 2001-04-03 | Merck & Co., Inc. | Transgenic mouse expressing a familial form of human amyloid precursor protein |
JPH08151377A (ja) | 1994-11-25 | 1996-06-11 | Kyowa Hakko Kogyo Co Ltd | キナゾリン誘導体 |
US6071903A (en) * | 1998-01-27 | 2000-06-06 | American Cyanamid Company | 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids |
KR100787254B1 (ko) * | 1999-01-22 | 2007-12-20 | 기린 홀딩스 가부시키가이샤 | 퀴놀린유도체 및 퀴나졸린유도체 |
MXPA02003140A (es) | 1999-11-22 | 2002-09-30 | Warner Lambert Co | Quinazolinas y su uso para la inhibicion de las enzimas cinasa dependientes del ciclin. |
ATE296809T1 (de) | 1999-11-23 | 2005-06-15 | Smithkline Beecham Corp | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren |
US20040087548A1 (en) * | 2001-02-27 | 2004-05-06 | Salvati Mark E. | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
JP2005505506A (ja) | 2001-06-12 | 2005-02-24 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病の治療に有用な大環状分子 |
ATE364384T1 (de) * | 2002-03-22 | 2007-07-15 | Janssen Pharmaceutica Nv | Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren |
WO2004058686A1 (en) | 2002-04-30 | 2004-07-15 | Elan Pharmaceuticals, Inc. | Hydroxypropyl amides for the treatment of alzheimer’s disease |
DE10301105B4 (de) | 2003-01-09 | 2005-11-24 | Chemisch-Pharmazeutisches Labor, Rolf Sachse Gmbh | Verwendung von 2-Amino-2H-chinazolin-Derivaten zur Behandlung von myeloproliferativen Erkrankungen, Bluthochdruck und Bronchodilation |
DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
PL375747A1 (en) * | 2002-09-06 | 2005-12-12 | Elan Pharmaceuticals, Inc. | 1, 3-diamino-2-hydroxypropane prodrug derivatives |
EP1407774A1 (en) | 2002-09-10 | 2004-04-14 | LION Bioscience AG | 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds |
EP1606280A4 (en) | 2003-03-18 | 2008-12-24 | Merck & Co Inc | CYCLOPENTYL HETEROCYLIC TETRAHYDROPYRANYL AMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
GB0325830D0 (en) | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
WO2006000020A1 (en) | 2004-06-29 | 2006-01-05 | European Nickel Plc | Improved leaching of base metals |
JP4898677B2 (ja) | 2004-08-06 | 2012-03-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | β−セクレターゼ(BACE)のインヒビターとして有用な2−アミノ−キナゾリン誘導体 |
US8383637B2 (en) * | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8436006B2 (en) | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8426429B2 (en) * | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
WO2006017844A1 (en) | 2004-08-06 | 2006-02-16 | Janssen Pharmaceutica, N.V. | NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) |
US20060074105A1 (en) * | 2004-09-20 | 2006-04-06 | Serenex, Inc. | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 |
EP1841426B1 (en) | 2005-01-19 | 2011-04-27 | Merck Sharp & Dohme Corp. | Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of alzheimer's disease |
EP1895898B1 (en) | 2005-06-29 | 2011-02-16 | Compumedics Limited | Sensor assembly with conductive bridge |
WO2007050612A1 (en) | 2005-10-25 | 2007-05-03 | Janssen Pharmaceutica N.V. | 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (bace) |
US7932261B2 (en) * | 2006-02-06 | 2011-04-26 | Janssen Pharmaceutica Nv | Macrocycle derivatives useful as inhibitors of β-secretase (BACE) |
US7776882B2 (en) * | 2006-02-06 | 2010-08-17 | Baxter Ellen W | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
US7868022B2 (en) * | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
EP2238111B1 (en) * | 2008-01-28 | 2013-01-16 | Janssen Pharmaceutica NV | 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of -secretase (bace) |
BRPI0907061A2 (pt) * | 2008-01-29 | 2015-07-07 | Janssen Pharmaceutica Nv | Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base) |
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2005
- 2005-08-04 US US11/197,615 patent/US8436006B2/en active Active
- 2005-08-08 PT PT05785256T patent/PT1776349E/pt unknown
- 2005-08-08 ES ES05785256T patent/ES2351667T3/es active Active
- 2005-08-08 WO PCT/US2005/028191 patent/WO2006017836A2/en active Application Filing
- 2005-08-08 CN CNA2005800341221A patent/CN101035771A/zh active Pending
- 2005-08-08 DK DK05785256.8T patent/DK1776349T3/da active
- 2005-08-08 PL PL05785256T patent/PL1776349T3/pl unknown
- 2005-08-08 JP JP2007525074A patent/JP4884387B2/ja not_active Expired - Fee Related
- 2005-08-08 DE DE602005024004T patent/DE602005024004D1/de active Active
- 2005-08-08 AT AT05785256T patent/ATE483692T1/de active
- 2005-08-08 RS RS20100564A patent/RS51630B/en unknown
- 2005-08-08 EP EP05785256A patent/EP1776349B1/en active Active
- 2005-08-08 SI SI200531177T patent/SI1776349T1/sl unknown
-
2010
- 2010-11-05 HR HR20100595T patent/HRP20100595T1/hr unknown
-
2011
- 2011-01-04 CY CY20111100022T patent/CY1111086T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2006017836A3 (en) | 2006-06-29 |
RS51630B (en) | 2011-08-31 |
US20060178383A1 (en) | 2006-08-10 |
DE602005024004D1 (de) | 2010-11-18 |
HRP20100595T1 (hr) | 2010-12-31 |
JP4884387B2 (ja) | 2012-02-29 |
JP2008509165A (ja) | 2008-03-27 |
PT1776349E (pt) | 2010-12-06 |
ES2351667T3 (es) | 2011-02-09 |
PL1776349T3 (pl) | 2011-04-29 |
SI1776349T1 (sl) | 2011-01-31 |
EP1776349A2 (en) | 2007-04-25 |
CN101035771A (zh) | 2007-09-12 |
US8436006B2 (en) | 2013-05-07 |
EP1776349B1 (en) | 2010-10-06 |
WO2006017836A2 (en) | 2006-02-16 |
DK1776349T3 (da) | 2011-01-24 |
ATE483692T1 (de) | 2010-10-15 |
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