SI1776349T1 - 2-amino-kinazolinski derivati, uporabni kot zaviralci beta-sekretaze (bace) - Google Patents
2-amino-kinazolinski derivati, uporabni kot zaviralci beta-sekretaze (bace)Info
- Publication number
- SI1776349T1 SI1776349T1 SI200531177T SI200531177T SI1776349T1 SI 1776349 T1 SI1776349 T1 SI 1776349T1 SI 200531177 T SI200531177 T SI 200531177T SI 200531177 T SI200531177 T SI 200531177T SI 1776349 T1 SI1776349 T1 SI 1776349T1
- Authority
- SI
- Slovenia
- Prior art keywords
- beta
- bace
- secretase
- inhibitors
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59981104P | 2004-08-06 | 2004-08-06 | |
EP05785256A EP1776349B1 (en) | 2004-08-06 | 2005-08-08 | 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (bace) |
PCT/US2005/028191 WO2006017836A2 (en) | 2004-08-06 | 2005-08-08 | 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (bace) |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1776349T1 true SI1776349T1 (sl) | 2011-01-31 |
Family
ID=35564387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200531177T SI1776349T1 (sl) | 2004-08-06 | 2005-08-08 | 2-amino-kinazolinski derivati, uporabni kot zaviralci beta-sekretaze (bace) |
Country Status (15)
Country | Link |
---|---|
US (1) | US8436006B2 (sl) |
EP (1) | EP1776349B1 (sl) |
JP (1) | JP4884387B2 (sl) |
CN (1) | CN101035771A (sl) |
AT (1) | ATE483692T1 (sl) |
CY (1) | CY1111086T1 (sl) |
DE (1) | DE602005024004D1 (sl) |
DK (1) | DK1776349T3 (sl) |
ES (1) | ES2351667T3 (sl) |
HR (1) | HRP20100595T1 (sl) |
PL (1) | PL1776349T3 (sl) |
PT (1) | PT1776349E (sl) |
RS (1) | RS51630B (sl) |
SI (1) | SI1776349T1 (sl) |
WO (1) | WO2006017836A2 (sl) |
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US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US8426429B2 (en) * | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8383637B2 (en) * | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8436006B2 (en) | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US7868000B2 (en) | 2005-06-14 | 2011-01-11 | Schering Corporation | Aspartyl protease inhibitors |
ES2436795T3 (es) | 2005-06-14 | 2014-01-07 | Merck Sharp & Dohme Corp. | Inhibidores heterocíclicos de aspartil proteasa, preparación y uso de los mismos |
ES2360957T3 (es) * | 2005-10-25 | 2011-06-10 | Janssen Pharmaceutica Nv | Derivados de 2-amino-3,4-dihidro-pirido(3,4-d)-pirimidina utiles como inhibidores de la beta-secretasa (bace). |
US7776882B2 (en) * | 2006-02-06 | 2010-08-17 | Baxter Ellen W | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
US7868022B2 (en) | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
WO2007092839A2 (en) * | 2006-02-06 | 2007-08-16 | Janssen Pharmaceutica N.V. | Macrocycle derivatives useful as inhibitors of beta-secretase (bace) |
AR061264A1 (es) | 2006-06-12 | 2008-08-13 | Schering Corp | Inhibidores de aspartil-proteasas derivados de pirimidina, composiciones farmaceuticas que los contienen y usos para tratar enfermedades cognitivas o neurodegenerativas, y como inhibidores del virus vih. |
US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
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JP2011518225A (ja) | 2008-04-22 | 2011-06-23 | シェーリング コーポレイション | Bace−1阻害剤としてのフェニル置換2−イミノ−3−メチルピロロピリミジノン化合物、組成物、およびそれらの使用 |
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EP2376083A4 (en) * | 2008-11-20 | 2012-06-20 | Purdue Research Foundation | CHINAZOLIN INHIBITORS OF BACE 1 AND METHOD OF USE |
US8859590B2 (en) | 2008-12-05 | 2014-10-14 | Purdue Research Foundation | Inhibitors of BACE1 and methods for treating Alzheimer's disease |
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RU2013150349A (ru) * | 2011-04-13 | 2015-05-20 | Мерк Шарп И Доум Корп. | 5-замещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов васе, содержащие их композиции и их применение |
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ES2360957T3 (es) * | 2005-10-25 | 2011-06-10 | Janssen Pharmaceutica Nv | Derivados de 2-amino-3,4-dihidro-pirido(3,4-d)-pirimidina utiles como inhibidores de la beta-secretasa (bace). |
WO2007092839A2 (en) * | 2006-02-06 | 2007-08-16 | Janssen Pharmaceutica N.V. | Macrocycle derivatives useful as inhibitors of beta-secretase (bace) |
US7776882B2 (en) * | 2006-02-06 | 2010-08-17 | Baxter Ellen W | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
US7868022B2 (en) * | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
BRPI0906625A2 (pt) * | 2008-01-28 | 2015-07-14 | Janssen Pharmaceutica Nv | Derivados de tio-2-amino-quinolina-6-substituída úteis como inibidores da beta-secretase (bace) |
AU2009209147B2 (en) * | 2008-01-29 | 2013-03-14 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of beta-secretase (BACE) |
-
2005
- 2005-08-04 US US11/197,615 patent/US8436006B2/en active Active
- 2005-08-08 DK DK05785256.8T patent/DK1776349T3/da active
- 2005-08-08 EP EP05785256A patent/EP1776349B1/en active Active
- 2005-08-08 ES ES05785256T patent/ES2351667T3/es active Active
- 2005-08-08 AT AT05785256T patent/ATE483692T1/de active
- 2005-08-08 PL PL05785256T patent/PL1776349T3/pl unknown
- 2005-08-08 WO PCT/US2005/028191 patent/WO2006017836A2/en active Application Filing
- 2005-08-08 PT PT05785256T patent/PT1776349E/pt unknown
- 2005-08-08 CN CNA2005800341221A patent/CN101035771A/zh active Pending
- 2005-08-08 RS RS20100564A patent/RS51630B/en unknown
- 2005-08-08 DE DE602005024004T patent/DE602005024004D1/de active Active
- 2005-08-08 SI SI200531177T patent/SI1776349T1/sl unknown
- 2005-08-08 JP JP2007525074A patent/JP4884387B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-05 HR HR20100595T patent/HRP20100595T1/hr unknown
-
2011
- 2011-01-04 CY CY20111100022T patent/CY1111086T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT1776349E (pt) | 2010-12-06 |
EP1776349B1 (en) | 2010-10-06 |
HRP20100595T1 (hr) | 2010-12-31 |
WO2006017836A3 (en) | 2006-06-29 |
DK1776349T3 (da) | 2011-01-24 |
PL1776349T3 (pl) | 2011-04-29 |
CN101035771A (zh) | 2007-09-12 |
JP4884387B2 (ja) | 2012-02-29 |
WO2006017836A2 (en) | 2006-02-16 |
EP1776349A2 (en) | 2007-04-25 |
ATE483692T1 (de) | 2010-10-15 |
RS51630B (en) | 2011-08-31 |
CY1111086T1 (el) | 2015-06-11 |
ES2351667T3 (es) | 2011-02-09 |
US20060178383A1 (en) | 2006-08-10 |
US8436006B2 (en) | 2013-05-07 |
JP2008509165A (ja) | 2008-03-27 |
DE602005024004D1 (de) | 2010-11-18 |
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