PL1789398T3 - Pochodne 2-amino-chinazoliny użyteczne jako inhibitory ß-sekretazy (BACE) - Google Patents
Pochodne 2-amino-chinazoliny użyteczne jako inhibitory ß-sekretazy (BACE)Info
- Publication number
- PL1789398T3 PL1789398T3 PL05780525T PL05780525T PL1789398T3 PL 1789398 T3 PL1789398 T3 PL 1789398T3 PL 05780525 T PL05780525 T PL 05780525T PL 05780525 T PL05780525 T PL 05780525T PL 1789398 T3 PL1789398 T3 PL 1789398T3
- Authority
- PL
- Poland
- Prior art keywords
- bace
- secretase
- inhibitors
- amino
- quinazoline derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101150058765 BACE1 gene Proteins 0.000 title 1
- CZAAKPFIWJXPQT-UHFFFAOYSA-N quinazolin-2-amine Chemical class C1=CC=CC2=NC(N)=NC=C21 CZAAKPFIWJXPQT-UHFFFAOYSA-N 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- GQRRWNLARRRPRY-UHFFFAOYSA-N 1,4-dihydroquinazolin-2-amine Chemical class C1=CC=C2CNC(N)=NC2=C1 GQRRWNLARRRPRY-UHFFFAOYSA-N 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 102100021257 Beta-secretase 1 Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- IXHBTMCLRNMKHZ-LBPRGKRZSA-N levobunolol Chemical compound O=C1CCCC2=C1C=CC=C2OC[C@@H](O)CNC(C)(C)C IXHBTMCLRNMKHZ-LBPRGKRZSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59981004P | 2004-08-06 | 2004-08-06 | |
| PCT/IB2005/002595 WO2006024932A1 (en) | 2004-08-06 | 2005-08-08 | 2-amino-quinazoline derivatives useful as inhibitors of b-secretase (bace) |
| EP05780525A EP1789398B1 (en) | 2004-08-06 | 2005-08-08 | 2-amino-quinazoline derivatives useful as inhibitors of b-secretase (bace) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1789398T3 true PL1789398T3 (pl) | 2011-03-31 |
Family
ID=35526992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05780525T PL1789398T3 (pl) | 2004-08-06 | 2005-08-08 | Pochodne 2-amino-chinazoliny użyteczne jako inhibitory ß-sekretazy (BACE) |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1789398B1 (pl) |
| JP (1) | JP4898677B2 (pl) |
| CN (1) | CN101035772B (pl) |
| AT (1) | ATE482936T1 (pl) |
| CY (1) | CY1111070T1 (pl) |
| DE (1) | DE602005023887D1 (pl) |
| DK (1) | DK1789398T3 (pl) |
| ES (1) | ES2349594T3 (pl) |
| HR (1) | HRP20100594T1 (pl) |
| PL (1) | PL1789398T3 (pl) |
| PT (1) | PT1789398E (pl) |
| RS (1) | RS51631B (pl) |
| SI (1) | SI1789398T1 (pl) |
| WO (1) | WO2006024932A1 (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US8426429B2 (en) | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8383637B2 (en) | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8436006B2 (en) | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| PE20070135A1 (es) | 2005-06-14 | 2007-03-09 | Schering Corp | Compuestos heterociclicos como inhibidores de aspartil proteasas |
| CA2610828A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Heterocyclic aspartyl protease inhibitors, preparation and use thereof |
| EP1917245A1 (de) | 2005-08-21 | 2008-05-07 | Abbott GmbH & Co. KG | Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| DE602006020773D1 (de) | 2005-10-25 | 2011-04-28 | Janssen Pharmaceutica Nv | Als inhibitoren von beta-sekretase (bace) geeignete 2-amino-3,4-dihydropyridoä3,4-düpyrimidinderivate |
| WO2007092846A2 (en) | 2006-02-06 | 2007-08-16 | Janssen Pharmaceutica N.V. | 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) |
| WO2007092839A2 (en) | 2006-02-06 | 2007-08-16 | Janssen Pharmaceutica N.V. | Macrocycle derivatives useful as inhibitors of beta-secretase (bace) |
| US7868022B2 (en) | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
| EP2644600B1 (en) | 2006-06-12 | 2017-01-11 | Merck Sharp & Dohme Corp. | Heterocyclic aspartyl protease inhibitors |
| TW200815349A (en) * | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| AU2007332754A1 (en) | 2006-12-12 | 2008-06-19 | Schering Corporation | Aspartyl protease inhibitors |
| EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
| US8222264B2 (en) | 2007-07-06 | 2012-07-17 | Boehringer Ingelheim International Gmbh | Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture |
| MX2010008202A (es) | 2008-01-28 | 2010-12-06 | Janssen Pharmaceutica Nv | Derivados de tio-2-aminoquinolina 6-sustituida utiles como inhibidores de beta-secretasa (bace). |
| WO2009097401A1 (en) * | 2008-01-29 | 2009-08-06 | Janssen Pharmaceutica N.V. | 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) |
| AR071385A1 (es) | 2008-04-22 | 2010-06-16 | Schering Corp | Compuestos de 2-imino-3-metil pirrolopirimidinona sustituida con tiofenilo,composiciones farmaceuticas que los contienen,y uso de los mismos para el tratamiento de patologias asociadas con la proteina beta amiloide,tales como alzheimer y otros formas de demencia. |
| WO2011063233A1 (en) | 2009-11-23 | 2011-05-26 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| US8481459B2 (en) * | 2010-06-14 | 2013-07-09 | Academia Sinica | Chemical inhibitors of ethylene biosynthesis |
| WO2014127881A1 (de) | 2013-02-25 | 2014-08-28 | Merck Patent Gmbh | 2-amino-3,4-dihydrc-chinazolin derivate und ihre verwendung als cathepsin d inhibitoren |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2544939B2 (ja) * | 1987-09-01 | 1996-10-16 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
| JP2726950B2 (ja) * | 1990-04-27 | 1998-03-11 | 富士写真フイルム株式会社 | カラー画像形成方法 |
| CN1732161A (zh) * | 2002-09-06 | 2006-02-08 | 艾伦药物公司 | 1,3－二氨基－2－羟基丙烷前体药物衍生物 |
| WO2004041211A2 (en) * | 2002-11-04 | 2004-05-21 | Georgetown University | INHIBITORS OF β-SECRETASE, AND THEIR USE FOR THE PREVENTION OR TREATMENT OF ALZHEIMER’S DISEASE OR MILD COGNITIVE IMPAIRMENT |
-
2005
- 2005-08-08 RS RS20100565A patent/RS51631B/sr unknown
- 2005-08-08 AT AT05780525T patent/ATE482936T1/de active
- 2005-08-08 CN CN2005800342281A patent/CN101035772B/zh not_active Expired - Fee Related
- 2005-08-08 JP JP2007524423A patent/JP4898677B2/ja not_active Expired - Fee Related
- 2005-08-08 PL PL05780525T patent/PL1789398T3/pl unknown
- 2005-08-08 HR HR20100594T patent/HRP20100594T1/hr unknown
- 2005-08-08 ES ES05780525T patent/ES2349594T3/es not_active Expired - Lifetime
- 2005-08-08 DE DE602005023887T patent/DE602005023887D1/de not_active Expired - Lifetime
- 2005-08-08 EP EP05780525A patent/EP1789398B1/en not_active Expired - Lifetime
- 2005-08-08 SI SI200531176T patent/SI1789398T1/sl unknown
- 2005-08-08 WO PCT/IB2005/002595 patent/WO2006024932A1/en not_active Ceased
- 2005-08-08 PT PT05780525T patent/PT1789398E/pt unknown
- 2005-08-08 DK DK05780525.1T patent/DK1789398T3/da active
-
2010
- 2010-12-29 CY CY20101101201T patent/CY1111070T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1789398T3 (da) | 2011-01-24 |
| ES2349594T3 (es) | 2011-01-05 |
| HRP20100594T1 (hr) | 2010-12-31 |
| JP2008509129A (ja) | 2008-03-27 |
| JP4898677B2 (ja) | 2012-03-21 |
| CY1111070T1 (el) | 2015-06-11 |
| ATE482936T1 (de) | 2010-10-15 |
| CN101035772A (zh) | 2007-09-12 |
| EP1789398A1 (en) | 2007-05-30 |
| EP1789398B1 (en) | 2010-09-29 |
| DE602005023887D1 (de) | 2010-11-11 |
| CN101035772B (zh) | 2011-12-14 |
| WO2006024932A1 (en) | 2006-03-09 |
| PT1789398E (pt) | 2010-10-21 |
| RS51631B (sr) | 2011-08-31 |
| SI1789398T1 (sl) | 2011-01-31 |
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