CY1111070T1 - Παραγωγα 2-αμινο-κουιναζολινης χρησιμα ως αναστολεις της β-σεκρετασης (bace) - Google Patents
Παραγωγα 2-αμινο-κουιναζολινης χρησιμα ως αναστολεις της β-σεκρετασης (bace)Info
- Publication number
- CY1111070T1 CY1111070T1 CY20101101201T CY101101201T CY1111070T1 CY 1111070 T1 CY1111070 T1 CY 1111070T1 CY 20101101201 T CY20101101201 T CY 20101101201T CY 101101201 T CY101101201 T CY 101101201T CY 1111070 T1 CY1111070 T1 CY 1111070T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bace
- inhibitors
- secretarise
- amine
- quinazoline derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Η παρούσα εφεύρεση αφορά πρωτότυπα παράγωγα 2-αμινο-3,4-διϋδρο-κουιναζολίνης, φαρμακευτικές συνθέσεις που περιέχουν τα εν λόγω παράγωγα και τη χρήση τους στη θεραπευτική αντιμετώπιση της νόσου Alzheimer (ΝΑ), και σχετικών διαταραχών. Οι χημικές ενώσεις της παρούσας εφεύρεσης είναι αναστολείς της β-σεκρετάσης, γνωστής και ως ένζυμο σχάσης β-θέσης αμυλοειδούς και BACE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59981004P | 2004-08-06 | 2004-08-06 | |
EP05780525A EP1789398B1 (en) | 2004-08-06 | 2005-08-08 | 2-amino-quinazoline derivatives useful as inhibitors of b-secretase (bace) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111070T1 true CY1111070T1 (el) | 2015-06-11 |
Family
ID=35526992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101101201T CY1111070T1 (el) | 2004-08-06 | 2010-12-29 | Παραγωγα 2-αμινο-κουιναζολινης χρησιμα ως αναστολεις της β-σεκρετασης (bace) |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1789398B1 (el) |
JP (1) | JP4898677B2 (el) |
CN (1) | CN101035772B (el) |
AT (1) | ATE482936T1 (el) |
CY (1) | CY1111070T1 (el) |
DE (1) | DE602005023887D1 (el) |
DK (1) | DK1789398T3 (el) |
ES (1) | ES2349594T3 (el) |
HR (1) | HRP20100594T1 (el) |
PL (1) | PL1789398T3 (el) |
PT (1) | PT1789398E (el) |
RS (1) | RS51631B (el) |
SI (1) | SI1789398T1 (el) |
WO (1) | WO2006024932A1 (el) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US8436006B2 (en) | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8383637B2 (en) | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8426429B2 (en) | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US7868000B2 (en) | 2005-06-14 | 2011-01-11 | Schering Corporation | Aspartyl protease inhibitors |
ES2436795T3 (es) | 2005-06-14 | 2014-01-07 | Merck Sharp & Dohme Corp. | Inhibidores heterocíclicos de aspartil proteasa, preparación y uso de los mismos |
US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
ES2360957T3 (es) | 2005-10-25 | 2011-06-10 | Janssen Pharmaceutica Nv | Derivados de 2-amino-3,4-dihidro-pirido(3,4-d)-pirimidina utiles como inhibidores de la beta-secretasa (bace). |
US7868022B2 (en) | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
US7776882B2 (en) | 2006-02-06 | 2010-08-17 | Baxter Ellen W | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
WO2007092839A2 (en) | 2006-02-06 | 2007-08-16 | Janssen Pharmaceutica N.V. | Macrocycle derivatives useful as inhibitors of beta-secretase (bace) |
AR061264A1 (es) | 2006-06-12 | 2008-08-13 | Schering Corp | Inhibidores de aspartil-proteasas derivados de pirimidina, composiciones farmaceuticas que los contienen y usos para tratar enfermedades cognitivas o neurodegenerativas, y como inhibidores del virus vih. |
TW200815349A (en) * | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
US8222264B2 (en) | 2007-07-06 | 2012-07-17 | Boehringer Ingelheim International Gmbh | Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture |
BRPI0906625A2 (pt) | 2008-01-28 | 2015-07-14 | Janssen Pharmaceutica Nv | Derivados de tio-2-amino-quinolina-6-substituída úteis como inibidores da beta-secretase (bace) |
AU2009209147B2 (en) * | 2008-01-29 | 2013-03-14 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of beta-secretase (BACE) |
JP2011518225A (ja) | 2008-04-22 | 2011-06-23 | シェーリング コーポレイション | Bace−1阻害剤としてのフェニル置換2−イミノ−3−メチルピロロピリミジノン化合物、組成物、およびそれらの使用 |
US9296698B2 (en) | 2009-11-23 | 2016-03-29 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
TWI411393B (zh) * | 2010-06-14 | 2013-10-11 | Academia Sinica | 乙烯生物合成之化學抑制劑 |
CA2902080A1 (en) | 2013-02-25 | 2014-08-28 | Merck Patent Gmbh | 2-amino-3,4-dihydroquinazoline derivatives and the use thereof as cathepsin d inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2544939B2 (ja) * | 1987-09-01 | 1996-10-16 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
JP2726950B2 (ja) * | 1990-04-27 | 1998-03-11 | 富士写真フイルム株式会社 | カラー画像形成方法 |
US7294642B2 (en) * | 2002-09-06 | 2007-11-13 | Elan Pharmaceuticals, Inc. | 1,3-Diamino-2-hydroxypropane pro-drug derivatives |
AU2003287513A1 (en) * | 2002-11-04 | 2004-06-07 | Georgetown University | INHIBITORS OF Beta-SECRETASE, AND THEIR USE FOR THE PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE OR MILD COGNITIVE IMPAIRMENT |
-
2005
- 2005-08-08 PT PT05780525T patent/PT1789398E/pt unknown
- 2005-08-08 DE DE602005023887T patent/DE602005023887D1/de active Active
- 2005-08-08 DK DK05780525.1T patent/DK1789398T3/da active
- 2005-08-08 JP JP2007524423A patent/JP4898677B2/ja not_active Expired - Fee Related
- 2005-08-08 CN CN2005800342281A patent/CN101035772B/zh not_active Expired - Fee Related
- 2005-08-08 EP EP05780525A patent/EP1789398B1/en active Active
- 2005-08-08 WO PCT/IB2005/002595 patent/WO2006024932A1/en active Application Filing
- 2005-08-08 SI SI200531176T patent/SI1789398T1/sl unknown
- 2005-08-08 RS RS20100565A patent/RS51631B/en unknown
- 2005-08-08 ES ES05780525T patent/ES2349594T3/es active Active
- 2005-08-08 PL PL05780525T patent/PL1789398T3/pl unknown
- 2005-08-08 AT AT05780525T patent/ATE482936T1/de active
-
2010
- 2010-11-05 HR HR20100594T patent/HRP20100594T1/hr unknown
- 2010-12-29 CY CY20101101201T patent/CY1111070T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE482936T1 (de) | 2010-10-15 |
HRP20100594T1 (hr) | 2010-12-31 |
RS51631B (en) | 2011-08-31 |
SI1789398T1 (sl) | 2011-01-31 |
ES2349594T3 (es) | 2011-01-05 |
CN101035772A (zh) | 2007-09-12 |
CN101035772B (zh) | 2011-12-14 |
PT1789398E (pt) | 2010-10-21 |
JP4898677B2 (ja) | 2012-03-21 |
PL1789398T3 (pl) | 2011-03-31 |
EP1789398A1 (en) | 2007-05-30 |
EP1789398B1 (en) | 2010-09-29 |
DE602005023887D1 (de) | 2010-11-11 |
JP2008509129A (ja) | 2008-03-27 |
WO2006024932A1 (en) | 2006-03-09 |
DK1789398T3 (da) | 2011-01-24 |
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