ATE482936T1 - Als b-sekretase (bace)-hemmer nützliche 2-amino- chinazolinderivate - Google Patents

Als b-sekretase (bace)-hemmer nützliche 2-amino- chinazolinderivate

Info

Publication number
ATE482936T1
ATE482936T1 AT05780525T AT05780525T ATE482936T1 AT E482936 T1 ATE482936 T1 AT E482936T1 AT 05780525 T AT05780525 T AT 05780525T AT 05780525 T AT05780525 T AT 05780525T AT E482936 T1 ATE482936 T1 AT E482936T1
Authority
AT
Austria
Prior art keywords
bace
secretase
inhibitors
amino
quinazoline derivatives
Prior art date
Application number
AT05780525T
Other languages
English (en)
Inventor
Francois Bishoff
Mirielle Braeken
Serge Pieters
Marc Mercken
Winter Hans De
Dieder Berthelot
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE482936T1 publication Critical patent/ATE482936T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT05780525T 2004-08-06 2005-08-08 Als b-sekretase (bace)-hemmer nützliche 2-amino- chinazolinderivate ATE482936T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59981004P 2004-08-06 2004-08-06
PCT/IB2005/002595 WO2006024932A1 (en) 2004-08-06 2005-08-08 2-amino-quinazoline derivatives useful as inhibitors of b-secretase (bace)

Publications (1)

Publication Number Publication Date
ATE482936T1 true ATE482936T1 (de) 2010-10-15

Family

ID=35526992

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05780525T ATE482936T1 (de) 2004-08-06 2005-08-08 Als b-sekretase (bace)-hemmer nützliche 2-amino- chinazolinderivate

Country Status (14)

Country Link
EP (1) EP1789398B1 (de)
JP (1) JP4898677B2 (de)
CN (1) CN101035772B (de)
AT (1) ATE482936T1 (de)
CY (1) CY1111070T1 (de)
DE (1) DE602005023887D1 (de)
DK (1) DK1789398T3 (de)
ES (1) ES2349594T3 (de)
HR (1) HRP20100594T1 (de)
PL (1) PL1789398T3 (de)
PT (1) PT1789398E (de)
RS (1) RS51631B (de)
SI (1) SI1789398T1 (de)
WO (1) WO2006024932A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
TW201004961A (en) 2005-06-14 2010-02-01 Schering Corp Aspartyl protease inhibitors
AU2006259573A1 (en) 2005-06-14 2006-12-28 Pharmacopeia, Inc. Heterocyclic aspartyl protease inhibitors, preparation and use thereof
US8686002B2 (en) 2005-08-21 2014-04-01 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
ATE502036T1 (de) 2005-10-25 2011-04-15 Janssen Pharmaceutica Nv Als inhibitoren von beta-sekretase (bace) geeignete 2-amino-3,4-dihydropyridoä3,4- düpyrimidinderivate
WO2007092839A2 (en) 2006-02-06 2007-08-16 Janssen Pharmaceutica N.V. Macrocycle derivatives useful as inhibitors of beta-secretase (bace)
WO2007092846A2 (en) 2006-02-06 2007-08-16 Janssen Pharmaceutica N.V. 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
US7868022B2 (en) 2006-02-06 2011-01-11 Janssen Pharmaceutica Nv 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
MX2008015956A (es) 2006-06-12 2009-01-09 Schering Corp Inhibidores heterociclicos de aspartil-proteasa.
TW200815349A (en) * 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
US8093254B2 (en) 2006-12-12 2012-01-10 Schering Corporation Aspartyl protease inhibitors
EP1935420A1 (de) * 2006-12-21 2008-06-25 Merck Sante 2-Adamantyl-Butyramid Derivate als selektive 11Beta-HSD1 Inhibitoren
US8222264B2 (en) 2007-07-06 2012-07-17 Boehringer Ingelheim International Gmbh Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture
AU2009209295A1 (en) 2008-01-28 2009-08-06 Janssen Pharmaceutica Nv 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of beta-secretase (BACE)
RU2010136050A (ru) * 2008-01-29 2012-03-10 Янссен Фармацевтика Нв (Be) 2-аминохинолиновые производные для использования в качестве ингибиторов секретазы (васе)
EA201001532A1 (ru) 2008-04-22 2011-06-30 Шеринг Корпорейшн Соединения фенилзамещенного 2-имино-3-метилпирролопиримидинона в качестве ингибиторов bace-1, композиции и их применение
WO2011063233A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
TWI411393B (zh) * 2010-06-14 2013-10-11 Academia Sinica 乙烯生物合成之化學抑制劑
WO2014127881A1 (de) 2013-02-25 2014-08-28 Merck Patent Gmbh 2-amino-3,4-dihydrc-chinazolin derivate und ihre verwendung als cathepsin d inhibitoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2544939B2 (ja) * 1987-09-01 1996-10-16 大塚製薬株式会社 ベンゾヘテロ環誘導体
JP2726950B2 (ja) * 1990-04-27 1998-03-11 富士写真フイルム株式会社 カラー画像形成方法
KR20050049485A (ko) * 2002-09-06 2005-05-25 엘란 파마슈티칼스, 인크. 1,3-디아미노-2-히드록시프로판 전구약물 유도체
WO2004041211A2 (en) * 2002-11-04 2004-05-21 Georgetown University INHIBITORS OF β-SECRETASE, AND THEIR USE FOR THE PREVENTION OR TREATMENT OF ALZHEIMER’S DISEASE OR MILD COGNITIVE IMPAIRMENT

Also Published As

Publication number Publication date
DK1789398T3 (da) 2011-01-24
CY1111070T1 (el) 2015-06-11
SI1789398T1 (sl) 2011-01-31
DE602005023887D1 (de) 2010-11-11
ES2349594T3 (es) 2011-01-05
CN101035772A (zh) 2007-09-12
PT1789398E (pt) 2010-10-21
WO2006024932A1 (en) 2006-03-09
JP2008509129A (ja) 2008-03-27
HRP20100594T1 (hr) 2010-12-31
EP1789398B1 (de) 2010-09-29
EP1789398A1 (de) 2007-05-30
PL1789398T3 (pl) 2011-03-31
RS51631B (en) 2011-08-31
CN101035772B (zh) 2011-12-14
JP4898677B2 (ja) 2012-03-21

Similar Documents

Publication Publication Date Title
ATE482936T1 (de) Als b-sekretase (bace)-hemmer nützliche 2-amino- chinazolinderivate
ATE483692T1 (de) Als beta-sekretase (bace)-hemmer nützliche 2- amino-chinazolinderivate
EP1841426A4 (de) Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer-krankheit
ATE502036T1 (de) Als inhibitoren von beta-sekretase (bace) geeignete 2-amino-3,4-dihydropyridoä3,4- düpyrimidinderivate
CY1108146T1 (el) ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ β-ΑΜΙΝΟ-ΕΤΕΡΟΚΥΚΛΙΚΗΣ-ΔΙΠΕΠΤΙΔΥΛΙΚΗΣ ΠΕΠΤΙΔΑΣΗΣ ΓΙΑ ΤΗΝ ΑΓΩΓΗ Ή ΠΡΟΛΗΨΗ ΤΟΥ ΔΙΑΒΗΤΗ
TW200728305A (en) Spiropiperidine beta-sectetase inhibitors for the treatment of alzheimer's disease
EP1673078A4 (de) Benzylether- und benzylamino-beta-sekretase-hemmer zur behandlung von alzheimer-krankheit
DE60327999D1 (de) Azolylaminoazine als inhibitoren von proteinkinasen
DE602004024572D1 (de) Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
MA27556A1 (fr) Derives de phenylalanine comme inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
DE60330485D1 (de) Zur behandlung von diabetes
WO2007092846A3 (en) 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
ATE517861T1 (de) Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
EP1817312A4 (de) Makrozyklische aminiopyridyl-beta-sekretase-hemmer zur behandlung von morbus alzheimer
ATE538651T1 (de) Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
WO2006078576A3 (en) Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
WO2006057945A3 (en) 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
WO2007058862A3 (en) Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
WO2006055434A3 (en) Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease
ATE538796T1 (de) Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit
WO2007019078A3 (en) Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease
WO2007019080A3 (en) Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease
EP1912963A4 (de) Cyclische ketale als beta-sekretase-inhibitoren zur behandlung von alzheimer-krankheit

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1789398

Country of ref document: EP