SI1789398T1 - 2-amino-kinazolinski derivati, uporabni kot inhibitorji b-sekretaze (bace) - Google Patents

2-amino-kinazolinski derivati, uporabni kot inhibitorji b-sekretaze (bace)

Info

Publication number
SI1789398T1
SI1789398T1 SI200531176T SI200531176T SI1789398T1 SI 1789398 T1 SI1789398 T1 SI 1789398T1 SI 200531176 T SI200531176 T SI 200531176T SI 200531176 T SI200531176 T SI 200531176T SI 1789398 T1 SI1789398 T1 SI 1789398T1
Authority
SI
Slovenia
Prior art keywords
bace
secretase
inhibitors
amino
quinazoline derivatives
Prior art date
Application number
SI200531176T
Other languages
English (en)
Inventor
Francois Paul Bishoff
Mirielle Braeken
Serge Maria Aloysius Pieters
Marc Hubert Mercken
Winter Hans Louis Jos De
Dieder Jean-Claude Berthelot
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SI1789398T1 publication Critical patent/SI1789398T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
SI200531176T 2004-08-06 2005-08-08 2-amino-kinazolinski derivati, uporabni kot inhibitorji b-sekretaze (bace) SI1789398T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59981004P 2004-08-06 2004-08-06
PCT/IB2005/002595 WO2006024932A1 (en) 2004-08-06 2005-08-08 2-amino-quinazoline derivatives useful as inhibitors of b-secretase (bace)
EP05780525A EP1789398B1 (en) 2004-08-06 2005-08-08 2-amino-quinazoline derivatives useful as inhibitors of b-secretase (bace)

Publications (1)

Publication Number Publication Date
SI1789398T1 true SI1789398T1 (sl) 2011-01-31

Family

ID=35526992

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200531176T SI1789398T1 (sl) 2004-08-06 2005-08-08 2-amino-kinazolinski derivati, uporabni kot inhibitorji b-sekretaze (bace)

Country Status (14)

Country Link
EP (1) EP1789398B1 (sl)
JP (1) JP4898677B2 (sl)
CN (1) CN101035772B (sl)
AT (1) ATE482936T1 (sl)
CY (1) CY1111070T1 (sl)
DE (1) DE602005023887D1 (sl)
DK (1) DK1789398T3 (sl)
ES (1) ES2349594T3 (sl)
HR (1) HRP20100594T1 (sl)
PL (1) PL1789398T3 (sl)
PT (1) PT1789398E (sl)
RS (1) RS51631B (sl)
SI (1) SI1789398T1 (sl)
WO (1) WO2006024932A1 (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8722708B2 (en) 2005-06-14 2014-05-13 Merck Sharp & Dohme Inc. Substituted isoindolines as aspartyl protease inhibitors
TWI332005B (en) 2005-06-14 2010-10-21 Schering Corp Aspartyl protease inhibitors
US8686002B2 (en) 2005-08-21 2014-04-01 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
EP1966198B1 (en) * 2005-10-25 2011-03-16 Janssen Pharmaceutica NV 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (bace)
US7776882B2 (en) 2006-02-06 2010-08-17 Baxter Ellen W 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE)
US7868022B2 (en) 2006-02-06 2011-01-11 Janssen Pharmaceutica Nv 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
WO2007092839A2 (en) 2006-02-06 2007-08-16 Janssen Pharmaceutica N.V. Macrocycle derivatives useful as inhibitors of beta-secretase (bace)
US8168641B2 (en) 2006-06-12 2012-05-01 Schering Corporation Aspartyl protease inhibitors
TW200815349A (en) * 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
WO2008073365A1 (en) 2006-12-12 2008-06-19 Schering Corporation Aspartyl protease inhibitors
EP1935420A1 (en) * 2006-12-21 2008-06-25 Merck Sante 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors
CA2687750C (en) * 2007-07-06 2016-10-18 Boehringer Ingelheim International Gmbh Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture
CN101925578B (zh) 2008-01-28 2012-11-28 詹森药业有限公司 可用作β-分泌酶(BACE)抑制剂的6-取代-硫代-2-氨基-喹啉衍生物
JP2011510993A (ja) * 2008-01-29 2011-04-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ β−セクレターゼ（ＢＡＣＥ）阻害剤として有用な２−アミノ−キノリン誘導体
AU2009239535A1 (en) 2008-04-22 2009-10-29 Schering Corporation Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
WO2011063233A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
TWI411393B (zh) * 2010-06-14 2013-10-11 Academia Sinica 乙烯生物合成之化學抑制劑
CA2902080A1 (en) 2013-02-25 2014-08-28 Merck Patent Gmbh 2-amino-3,4-dihydroquinazoline derivatives and the use thereof as cathepsin d inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2544939B2 (ja) * 1987-09-01 1996-10-16 大塚製薬株式会社 ベンゾヘテロ環誘導体
JP2726950B2 (ja) * 1990-04-27 1998-03-11 富士写真フイルム株式会社 カラー画像形成方法
US7294642B2 (en) * 2002-09-06 2007-11-13 Elan Pharmaceuticals, Inc. 1,3-Diamino-2-hydroxypropane pro-drug derivatives
WO2004041211A2 (en) * 2002-11-04 2004-05-21 Georgetown University INHIBITORS OF β-SECRETASE, AND THEIR USE FOR THE PREVENTION OR TREATMENT OF ALZHEIMER’S DISEASE OR MILD COGNITIVE IMPAIRMENT

Also Published As

Publication number Publication date
CY1111070T1 (el) 2015-06-11
JP4898677B2 (ja) 2012-03-21
RS51631B (en) 2011-08-31
PT1789398E (pt) 2010-10-21
WO2006024932A1 (en) 2006-03-09
PL1789398T3 (pl) 2011-03-31
EP1789398A1 (en) 2007-05-30
JP2008509129A (ja) 2008-03-27
DK1789398T3 (da) 2011-01-24
ATE482936T1 (de) 2010-10-15
ES2349594T3 (es) 2011-01-05
DE602005023887D1 (de) 2010-11-11
EP1789398B1 (en) 2010-09-29
HRP20100594T1 (hr) 2010-12-31
CN101035772B (zh) 2011-12-14
CN101035772A (zh) 2007-09-12

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