BRPI0907061A2 - Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base) - Google Patents

Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base)

Info

Publication number
BRPI0907061A2
BRPI0907061A2 BRPI0907061-3A BRPI0907061A BRPI0907061A2 BR PI0907061 A2 BRPI0907061 A2 BR PI0907061A2 BR PI0907061 A BRPI0907061 A BR PI0907061A BR PI0907061 A2 BRPI0907061 A2 BR PI0907061A2
Authority
BR
Brazil
Prior art keywords
beta
base
derivatives useful
secretase inhibitors
aminoquinoline derivatives
Prior art date
Application number
BRPI0907061-3A
Other languages
English (en)
Inventor
Ellen Baxter
Christopher J Creighton
Chih Yung Ho
Yifang Huang
Tianbao Lu
Chi Luo
Allen B Reitz
Charles H Reynolds
Tina Morgan Ross
Ellen Sieber-Mcmaster
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0907061A2 publication Critical patent/BRPI0907061A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
BRPI0907061-3A 2008-01-29 2009-01-29 Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base) BRPI0907061A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2424408P 2008-01-29 2008-01-29
PCT/US2009/032393 WO2009097401A1 (en) 2008-01-29 2009-01-29 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)

Publications (1)

Publication Number Publication Date
BRPI0907061A2 true BRPI0907061A2 (pt) 2015-07-07

Family

ID=40488089

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0907061-3A BRPI0907061A2 (pt) 2008-01-29 2009-01-29 Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base)

Country Status (14)

Country Link
US (1) US7786116B2 (pt)
EP (1) EP2240472B1 (pt)
JP (1) JP2011510993A (pt)
KR (1) KR20100118983A (pt)
CN (1) CN101970429B (pt)
AU (1) AU2009209147B2 (pt)
BR (1) BRPI0907061A2 (pt)
CA (1) CA2714008A1 (pt)
ES (1) ES2397682T3 (pt)
IL (1) IL207100A (pt)
MX (1) MX2010008243A (pt)
NZ (1) NZ586830A (pt)
RU (1) RU2010136050A (pt)
WO (1) WO2009097401A1 (pt)

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WO2006138265A2 (en) 2005-06-14 2006-12-28 Schering Corporation Heterocyclic aspartyl protease inhibitors, preparation and use thereof
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WO2011090911A1 (en) * 2010-01-19 2011-07-28 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
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CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
WO2012147763A1 (ja) 2011-04-26 2012-11-01 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
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US9540359B2 (en) 2012-10-24 2017-01-10 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity
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CN112263583B (zh) * 2020-11-23 2021-10-22 诸城市精神卫生中心 一种治疗帕金森疾病的药物及其制备方法

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Also Published As

Publication number Publication date
AU2009209147A1 (en) 2009-08-06
AU2009209147B2 (en) 2013-03-14
CN101970429A (zh) 2011-02-09
KR20100118983A (ko) 2010-11-08
WO2009097401A1 (en) 2009-08-06
RU2010136050A (ru) 2012-03-10
JP2011510993A (ja) 2011-04-07
US20090227581A1 (en) 2009-09-10
EP2240472A1 (en) 2010-10-20
ES2397682T3 (es) 2013-03-08
US7786116B2 (en) 2010-08-31
IL207100A (en) 2013-10-31
CA2714008A1 (en) 2009-08-06
CN101970429B (zh) 2013-05-29
MX2010008243A (es) 2010-11-30
NZ586830A (en) 2012-02-24
EP2240472B1 (en) 2012-11-21
IL207100A0 (en) 2010-12-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2363 DE 19-04-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.