BR0008608A - Derivados de pirazol-3-ona - Google Patents

Derivados de pirazol-3-ona

Info

Publication number
BR0008608A
BR0008608A BR0008608-8A BR0008608A BR0008608A BR 0008608 A BR0008608 A BR 0008608A BR 0008608 A BR0008608 A BR 0008608A BR 0008608 A BR0008608 A BR 0008608A
Authority
BR
Brazil
Prior art keywords
derivatives
pyrazole
pirazol
prophylaxis
coagulation
Prior art date
Application number
BR0008608-8A
Other languages
English (en)
Inventor
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Christos Tsaklakidis
Hanns Wurziger
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Ges Mit Beschaenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschaenk filed Critical Merck Patent Ges Mit Beschaenk
Publication of BR0008608A publication Critical patent/BR0008608A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE PIRAZOL-3-ONA". A invenção refere-se a novos compostos de fórmula I em que R^ 1^, R^ 2^, R^ 3^, R^ 4^, X e Y têm o significado indicado na reivindicação 1 de Patente, são inibidores de fator de coagulação Xa e podem ser empregados para a profilaxia e/ou terapia de distúrbios tromboembólicos.
BR0008608-8A 1999-03-03 2000-02-29 Derivados de pirazol-3-ona BR0008608A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19909237A DE19909237A1 (de) 1999-03-03 1999-03-03 Pyrazol-3-on-derivate
PCT/EP2000/001695 WO2000051989A1 (de) 1999-03-03 2000-02-29 Pyrazol-3-on-derivate als faktor xa inhibitoren

Publications (1)

Publication Number Publication Date
BR0008608A true BR0008608A (pt) 2002-01-02

Family

ID=7899522

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008608-8A BR0008608A (pt) 1999-03-03 2000-02-29 Derivados de pirazol-3-ona

Country Status (17)

Country Link
EP (1) EP1157010A1 (pt)
JP (1) JP2002538143A (pt)
KR (1) KR20010102428A (pt)
CN (1) CN1342148A (pt)
AU (1) AU2916500A (pt)
BR (1) BR0008608A (pt)
CA (1) CA2364908A1 (pt)
CZ (1) CZ20013164A3 (pt)
DE (1) DE19909237A1 (pt)
HU (1) HUP0200242A3 (pt)
MX (1) MXPA01008844A (pt)
NO (1) NO20014234L (pt)
PL (1) PL350941A1 (pt)
RU (1) RU2001126566A (pt)
SK (1) SK12152001A3 (pt)
WO (1) WO2000051989A1 (pt)
ZA (1) ZA200108064B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
JPWO2005012255A1 (ja) * 2003-08-01 2006-09-14 三菱ウェルファーマ株式会社 炎症性関節疾患の治療剤
DE102008020113A1 (de) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituierte Dihydropyrazolone und ihre Verwendung
DE102005019712A1 (de) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
DE102006050515A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dipyridiyl-dihydropyrazolone und ihre Verwendung
DE102006050516A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102006050513A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substitiuierte Dihydropyrazolone und ihre Verwendung
DE102007044032A1 (de) 2007-09-14 2009-03-19 Bayer Healthcare Ag Substituierte heterocyclische Verbindungen und ihre Verwendung
DE102007048447A1 (de) 2007-10-10 2009-04-16 Bayer Healthcare Ag Substituierte Dihydropyrazolthione und ihre Verwendung
DE102010044131A1 (de) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
JP3994453B2 (ja) * 1995-10-13 2007-10-17 日産化学工業株式会社 ピラゾロン類

Also Published As

Publication number Publication date
PL350941A1 (en) 2003-02-24
NO20014234D0 (no) 2001-08-31
EP1157010A1 (de) 2001-11-28
MXPA01008844A (es) 2002-05-14
RU2001126566A (ru) 2004-02-27
NO20014234L (no) 2001-10-24
JP2002538143A (ja) 2002-11-12
CZ20013164A3 (cs) 2001-12-12
HUP0200242A3 (en) 2002-12-28
KR20010102428A (ko) 2001-11-15
CN1342148A (zh) 2002-03-27
WO2000051989A1 (de) 2000-09-08
CA2364908A1 (en) 2000-09-08
ZA200108064B (en) 2003-01-02
AU2916500A (en) 2000-09-21
DE19909237A1 (de) 2000-09-07
HUP0200242A2 (hu) 2002-11-28
SK12152001A3 (sk) 2002-03-05

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]