HUP0200242A3 - Pyrazole-3-on-derivatives as factor xa inhibitors, pharmaceutical compositions containing them, their preparation and their use - Google Patents

Pyrazole-3-on-derivatives as factor xa inhibitors, pharmaceutical compositions containing them, their preparation and their use

Info

Publication number
HUP0200242A3
HUP0200242A3 HU0200242A HUP0200242A HUP0200242A3 HU P0200242 A3 HUP0200242 A3 HU P0200242A3 HU 0200242 A HU0200242 A HU 0200242A HU P0200242 A HUP0200242 A HU P0200242A HU P0200242 A3 HUP0200242 A3 HU P0200242A3
Authority
HU
Hungary
Prior art keywords
pyrazole
inhibitors
derivatives
factor
preparation
Prior art date
Application number
HU0200242A
Other languages
Hungarian (hu)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0200242A2 publication Critical patent/HUP0200242A2/en
Publication of HUP0200242A3 publication Critical patent/HUP0200242A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
HU0200242A 1999-03-03 2000-02-29 Pyrazole-3-on-derivatives as factor xa inhibitors, pharmaceutical compositions containing them, their preparation and their use HUP0200242A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19909237A DE19909237A1 (en) 1999-03-03 1999-03-03 Pyrazol-3-one derivatives

Publications (2)

Publication Number Publication Date
HUP0200242A2 HUP0200242A2 (en) 2002-11-28
HUP0200242A3 true HUP0200242A3 (en) 2002-12-28

Family

ID=7899522

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200242A HUP0200242A3 (en) 1999-03-03 2000-02-29 Pyrazole-3-on-derivatives as factor xa inhibitors, pharmaceutical compositions containing them, their preparation and their use

Country Status (17)

Country Link
EP (1) EP1157010A1 (en)
JP (1) JP2002538143A (en)
KR (1) KR20010102428A (en)
CN (1) CN1342148A (en)
AU (1) AU2916500A (en)
BR (1) BR0008608A (en)
CA (1) CA2364908A1 (en)
CZ (1) CZ20013164A3 (en)
DE (1) DE19909237A1 (en)
HU (1) HUP0200242A3 (en)
MX (1) MXPA01008844A (en)
NO (1) NO20014234L (en)
PL (1) PL350941A1 (en)
RU (1) RU2001126566A (en)
SK (1) SK12152001A3 (en)
WO (1) WO2000051989A1 (en)
ZA (1) ZA200108064B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
JP4744149B2 (en) 2002-12-03 2011-08-10 ファーマサイクリックス インコーポレイテッド 2- (2-Hydroxybiphenyl-3-yl) -1H-benzimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
WO2005012255A1 (en) * 2003-08-01 2005-02-10 Mitsubishi Pharma Corporation Remedy for inflammatory joint diseases
DE102008020113A1 (en) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituted dihydropyrazolones and their use
DE102005019712A1 (en) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone and its use
DE102006050513A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New substituted dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia
DE102006050515A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New substituted dipyridiyl-dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia
DE102006050516A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New pyrazol-3-one compounds are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful e.g. to treat and/or prophylaxis heart-circulation diseases, heart failure, anemia, chronic kidney diseases and renal failure
DE102007044032A1 (en) 2007-09-14 2009-03-19 Bayer Healthcare Ag New substituted heteroaryl compounds are hypoxia-inducible factor prolyl-4-hydroxylase inhibitors useful to treat and/or prevent e.g. circulatory heart diseases, heart failure, anemia, chronic kidney diseases and renal failure
DE102007048447A1 (en) 2007-10-10 2009-04-16 Bayer Healthcare Ag New substituted dihydropyrazole-3-thione compounds are hypoxia inducible factor-prolyl-4-hydroxylase inhibitor, useful for preparing medicament to treat and/or prevent e.g. cardiovascular diseases, wound healing and anemia
DE102010044131A1 (en) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituted sodium 1H-pyrazole-5-olate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
JP3994453B2 (en) * 1995-10-13 2007-10-17 日産化学工業株式会社 Pyrazolones

Also Published As

Publication number Publication date
DE19909237A1 (en) 2000-09-07
BR0008608A (en) 2002-01-02
AU2916500A (en) 2000-09-21
NO20014234D0 (en) 2001-08-31
PL350941A1 (en) 2003-02-24
EP1157010A1 (en) 2001-11-28
CA2364908A1 (en) 2000-09-08
NO20014234L (en) 2001-10-24
SK12152001A3 (en) 2002-03-05
WO2000051989A1 (en) 2000-09-08
KR20010102428A (en) 2001-11-15
ZA200108064B (en) 2003-01-02
RU2001126566A (en) 2004-02-27
CZ20013164A3 (en) 2001-12-12
MXPA01008844A (en) 2002-05-14
JP2002538143A (en) 2002-11-12
CN1342148A (en) 2002-03-27
HUP0200242A2 (en) 2002-11-28

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