NO20014234L - Pyrazol-3-one derivatives as factor Xa inhibitors - Google Patents

Pyrazol-3-one derivatives as factor Xa inhibitors

Info

Publication number
NO20014234L
NO20014234L NO20014234A NO20014234A NO20014234L NO 20014234 L NO20014234 L NO 20014234L NO 20014234 A NO20014234 A NO 20014234A NO 20014234 A NO20014234 A NO 20014234A NO 20014234 L NO20014234 L NO 20014234L
Authority
NO
Norway
Prior art keywords
pyrazol
inhibitors
derivatives
factor
prophylaxis
Prior art date
Application number
NO20014234A
Other languages
Norwegian (no)
Other versions
NO20014234D0 (en
Inventor
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Christos Tsaklakidis
Hanns Wurziger
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20014234D0 publication Critical patent/NO20014234D0/en
Publication of NO20014234L publication Critical patent/NO20014234L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Nye forbindelser med formel (I) R'-^N^o N-ti / \¿ R3 (I) hvor R1, R2, R3, R4, x og Y har de i patentkrav l angitte betydninger, er inhibitorer for koagulasjonsfaktoren Xa og kan anvendes til profylakse og/eller terapi av tromboemboliske sykdommer.Novel Compounds of Formula (I) R 1 - N 2 O N-ti / R 3 (I) wherein R 1, R 2, R 3, R 4, x, and Y can be used for prophylaxis and / or therapy of thromboembolic diseases.

NO20014234A 1999-03-03 2001-08-31 Pyrazol-3-one derivatives as factor Xa inhibitors NO20014234L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19909237A DE19909237A1 (en) 1999-03-03 1999-03-03 Pyrazol-3-one derivatives
PCT/EP2000/001695 WO2000051989A1 (en) 1999-03-03 2000-02-29 Pyrazole-3-on-derivative as factor xa inhibitors

Publications (2)

Publication Number Publication Date
NO20014234D0 NO20014234D0 (en) 2001-08-31
NO20014234L true NO20014234L (en) 2001-10-24

Family

ID=7899522

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014234A NO20014234L (en) 1999-03-03 2001-08-31 Pyrazol-3-one derivatives as factor Xa inhibitors

Country Status (17)

Country Link
EP (1) EP1157010A1 (en)
JP (1) JP2002538143A (en)
KR (1) KR20010102428A (en)
CN (1) CN1342148A (en)
AU (1) AU2916500A (en)
BR (1) BR0008608A (en)
CA (1) CA2364908A1 (en)
CZ (1) CZ20013164A3 (en)
DE (1) DE19909237A1 (en)
HU (1) HUP0200242A3 (en)
MX (1) MXPA01008844A (en)
NO (1) NO20014234L (en)
PL (1) PL350941A1 (en)
RU (1) RU2001126566A (en)
SK (1) SK12152001A3 (en)
WO (1) WO2000051989A1 (en)
ZA (1) ZA200108064B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
CA2507707C (en) 2002-12-03 2011-06-21 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
JPWO2005012255A1 (en) * 2003-08-01 2006-09-14 三菱ウェルファーマ株式会社 Treatment for inflammatory joint diseases
DE102008020113A1 (en) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituted dihydropyrazolones and their use
DE102005019712A1 (en) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone and its use
DE102006050516A1 (en) * 2006-10-26 2008-04-30 Bayer Healthcare Ag New pyrazol-3-one compounds are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful e.g. to treat and/or prophylaxis heart-circulation diseases, heart failure, anemia, chronic kidney diseases and renal failure
DE102006050513A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New substituted dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia
DE102006050515A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New substituted dipyridiyl-dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia
DE102007044032A1 (en) 2007-09-14 2009-03-19 Bayer Healthcare Ag New substituted heteroaryl compounds are hypoxia-inducible factor prolyl-4-hydroxylase inhibitors useful to treat and/or prevent e.g. circulatory heart diseases, heart failure, anemia, chronic kidney diseases and renal failure
DE102007048447A1 (en) 2007-10-10 2009-04-16 Bayer Healthcare Ag New substituted dihydropyrazole-3-thione compounds are hypoxia inducible factor-prolyl-4-hydroxylase inhibitor, useful for preparing medicament to treat and/or prevent e.g. cardiovascular diseases, wound healing and anemia
DE102010044131A1 (en) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituted sodium 1H-pyrazole-5-olate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
JP3994453B2 (en) * 1995-10-13 2007-10-17 日産化学工業株式会社 Pyrazolones

Also Published As

Publication number Publication date
WO2000051989A1 (en) 2000-09-08
CA2364908A1 (en) 2000-09-08
BR0008608A (en) 2002-01-02
MXPA01008844A (en) 2002-05-14
HUP0200242A2 (en) 2002-11-28
AU2916500A (en) 2000-09-21
CN1342148A (en) 2002-03-27
KR20010102428A (en) 2001-11-15
NO20014234D0 (en) 2001-08-31
CZ20013164A3 (en) 2001-12-12
HUP0200242A3 (en) 2002-12-28
SK12152001A3 (en) 2002-03-05
RU2001126566A (en) 2004-02-27
DE19909237A1 (en) 2000-09-07
JP2002538143A (en) 2002-11-12
EP1157010A1 (en) 2001-11-28
PL350941A1 (en) 2003-02-24
ZA200108064B (en) 2003-01-02

Similar Documents

Publication Publication Date Title
NO20002958L (en) Benzamidine derivatives as coagulation factor Xa inhibitors
NO20051600L (en) 1,4-disubstituted piperidine derivatives and their use as 11-betaHSD1 inhibitors
NO20006282L (en) New cyclosporins
NO986180L (en) Novel amidino derivatives and their use as thrombin inhibitors
NO20061660L (en) 2-pyridone derivatives as neutrophil elasae inhibitor and their use
NO20061700L (en) 2-pyridone derivatives as neutrophil elastase inhibitors and their use
NO20072399L (en) New pyrrolo [3,2-d] pyrimidin-4-o derivatives and their use in therapy
ATE359271T1 (en) PHENYL DERIVATIVES
NO965524L (en) Tri-substituted phenyl derivatives useful as PDE IV inhibitors
NO20025821L (en) 2-aminocarbonyl-9H-purine
NO20050199L (en) Azadicyclooctane and nonander derivatives with DDP-IV inhibitory activity
NO20082629L (en) Macrocyclic factor VIIa inhibitors useful as anticoagulants
NO20076066L (en) Oxadiazole derivatives as DGAT inhibitors
NO20062950L (en) 5,7-diaminopyrazolo-43-Dlpyrimidines with PDE-5 inhibitory activity
NO992770L (en) Novel heterocyclic substituted benzamides and their use in combating diseases
NO20055977L (en) New benzimidazole derivatives
MY107740A (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
NO992492L (en) Benzamidoaldehydes and their use as cysteine protease inhibitors
NO20062136L (en) Imidazopyrazintyrosin kinase inhibitors
NO20014234L (en) Pyrazol-3-one derivatives as factor Xa inhibitors
NO20023161L (en) Substituted piperidines, drugs containing these compounds and processes for their preparation
NO20061789L (en) Aminopyridine derivatives as inducible NO synthase inhibitors
NO20001483L (en) Novel NPY agonists
NO20051844L (en) Piperazine derivatives and process for their use.
DK1077218T3 (en) Peptidomimetic compounds comprising RGD sequences useful as integrin inhibitors

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application