BR9910021A - Derivados de bifenila - Google Patents

Derivados de bifenila

Info

Publication number
BR9910021A
BR9910021A BR9910021-5A BR9910021A BR9910021A BR 9910021 A BR9910021 A BR 9910021A BR 9910021 A BR9910021 A BR 9910021A BR 9910021 A BR9910021 A BR 9910021A
Authority
BR
Brazil
Prior art keywords
biphenyl derivatives
derivatives
byphenyl
prophylaxis
inhibitors
Prior art date
Application number
BR9910021-5A
Other languages
English (en)
Inventor
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Hanns Wurziger
Hans-Peter Buchstaller
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9910021A publication Critical patent/BR9910021A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE BIFENILA"<D>. Novos compostos de fórmula I em que X, R¹, R², R³, R^ 4^ e R^ 5^ têm o significado indicado na reivindicação 1 da patente, são inibidores do fator da coagulação Xa e podem ser empregados para a profilaxia e/ou terapia de distúrbios tromboembólicos.
BR9910021-5A 1998-04-30 1999-04-12 Derivados de bifenila BR9910021A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19819548A DE19819548A1 (de) 1998-04-30 1998-04-30 Biphenylderivate
PCT/EP1999/002457 WO1999057096A1 (de) 1998-04-30 1999-04-12 Biphenylderivate

Publications (1)

Publication Number Publication Date
BR9910021A true BR9910021A (pt) 2000-12-26

Family

ID=7866421

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910021-5A BR9910021A (pt) 1998-04-30 1999-04-12 Derivados de bifenila

Country Status (19)

Country Link
US (1) US6380430B1 (pt)
EP (1) EP1076643A1 (pt)
JP (1) JP2002513780A (pt)
KR (1) KR20010052249A (pt)
CN (1) CN1299343A (pt)
AR (1) AR019264A1 (pt)
AU (1) AU750472B2 (pt)
BR (1) BR9910021A (pt)
CA (1) CA2328732A1 (pt)
DE (1) DE19819548A1 (pt)
HU (1) HUP0102220A3 (pt)
ID (1) ID27152A (pt)
NO (1) NO20005435D0 (pt)
PL (1) PL343598A1 (pt)
RU (1) RU2219166C2 (pt)
SK (1) SK15962000A3 (pt)
UA (1) UA58593C2 (pt)
WO (1) WO1999057096A1 (pt)
ZA (1) ZA200007039B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010101772A (ko) * 1999-01-28 2001-11-14 야스이 쇼사꾸 방출제어제제
DE19945302A1 (de) * 1999-09-22 2001-03-29 Merck Patent Gmbh Biphenylderivate als NHE-3-Inhibitoren
DE10027024A1 (de) * 2000-05-31 2001-12-06 Merck Patent Gmbh Carbaminsäureester
JP2004501913A (ja) * 2000-06-23 2004-01-22 ブリストル−マイヤーズ　スクイブ　ファーマ　カンパニー ヘテロアリール−フェニル置換Ｘａ因子阻害剤
DE10037146A1 (de) * 2000-07-29 2002-02-07 Merck Patent Gmbh Acetamidderivate
CN100513398C (zh) 2002-12-03 2009-07-15 Axys药物公司 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5922697B2 (ja) 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
US4086244A (en) * 1976-12-10 1978-04-25 E. R. Squibb & Sons, Inc. Amidines
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PL316438A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
GB9600063D0 (en) * 1996-01-03 1996-03-06 Fujisawa Pharmaceutical Co Guaridine derivatives

Also Published As

Publication number Publication date
PL343598A1 (en) 2001-08-27
ID27152A (id) 2001-03-08
EP1076643A1 (de) 2001-02-21
WO1999057096A1 (de) 1999-11-11
AR019264A1 (es) 2002-02-13
DE19819548A1 (de) 1999-11-04
US6380430B1 (en) 2002-04-30
HUP0102220A2 (hu) 2001-10-28
ZA200007039B (en) 2002-02-28
AU3815499A (en) 1999-11-23
NO20005435L (no) 2000-10-27
JP2002513780A (ja) 2002-05-14
CA2328732A1 (en) 1999-11-11
NO20005435D0 (no) 2000-10-27
AU750472B2 (en) 2002-07-18
KR20010052249A (ko) 2001-06-25
HUP0102220A3 (en) 2002-11-28
UA58593C2 (uk) 2003-08-15
CN1299343A (zh) 2001-06-13
SK15962000A3 (sk) 2001-05-10
RU2219166C2 (ru) 2003-12-20

Similar Documents

Publication Publication Date Title
BR9812699A (pt) Derivados de benzamidina
BR0116804A (pt) Derivados fenìlicos
BR9811685A (pt) Derivados de piridina
BR0116115A (pt) Derivados de carboxamida e seu uso no tratamento de doenças tromboembólicas e tumores
BR9813835A (pt) Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromboembólica
DK0842934T3 (da) 5-HT1F agonister
GB9801690D0 (en) Therapeutic agents
BR9907435A (pt) Formulações quìmicas para a incorporação em adesivos usados na produção de materiais de madeira ou compósitos de madeira
NO20040100L (no) Nye forbindelser som anti-inflammasjons, immunmodulerende og anti-proliferative midler
EA200000048A1 (ru) ИНГИБИТОРЫ ФАКТОРА Ха, СОДЕРЖАЩИЕ ГРУППУ С НЕЙТРАЛЬНОЙ P1-СПЕЦИФИЧНОСТЬЮ
BR9813028A (pt) Agonistas de prostaglandina e seu uso para tratar distúrbios nos ossos
PT1149092E (pt) 4- e 5-alciniloxindois e 4- e 5-alceniloxindois
BR0002518A (pt) Derivados de 4-arilpiperidina para o tratamento de prurido
DE60324544D1 (de) Muskarin antagonisten
BR9912072A (pt) Derivados diacil-hidrazina
DK0672659T3 (da) Antitrombotiske midler
WO2000071516A3 (en) INHIBITORS OF FACTOR Xa
DE60121461D1 (de) Kondensierte pyridoindolderivate
BR0008608A (pt) Derivados de pirazol-3-ona
BR9910021A (pt) Derivados de bifenila
BR9916774A (pt) Derivados de imidazo[4,5-c]piridina-4-ona
MY130736A (en) Imidazo(4,5-c) pyridin-4-one derivatives
BR0109483A (pt) Pró-drogas de derivados de imidazopiridina
BR9813719A (pt) Agentes terapêuticos
NO995963D0 (no) Karboksamider anvendelige som 5-HTIF-agonister

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.