ZA200404549B - Drivatives of phenoxy-N-[4-(1,1-dioxoisothiazolidin-2-yl)phenyl]-valeramide and other compounds as inhibitors of coagulation factor Xa for treatment of thromboembolic diseases and tumuors. - Google Patents
Drivatives of phenoxy-N-[4-(1,1-dioxoisothiazolidin-2-yl)phenyl]-valeramide and other compounds as inhibitors of coagulation factor Xa for treatment of thromboembolic diseases and tumuors. Download PDFInfo
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- ZA200404549B ZA200404549B ZA200404549A ZA200404549A ZA200404549B ZA 200404549 B ZA200404549 B ZA 200404549B ZA 200404549 A ZA200404549 A ZA 200404549A ZA 200404549 A ZA200404549 A ZA 200404549A ZA 200404549 B ZA200404549 B ZA 200404549B
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- South Africa
- Prior art keywords
- phenyl
- hal
- monosubstituted
- solvates
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- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- UHNHTTIUNATJKL-UHFFFAOYSA-N n-methylmethanesulfonamide Chemical group CNS(C)(=O)=O UHNHTTIUNATJKL-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940021317 other blood product in atc Drugs 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 description 1
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000003607 serino group Chemical class [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10155075A DE10155075A1 (de) | 2001-11-09 | 2001-11-09 | Cyclische Sulfonamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200404549B true ZA200404549B (en) | 2005-02-04 |
Family
ID=7705183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200404549A ZA200404549B (en) | 2001-11-09 | 2004-06-08 | Drivatives of phenoxy-N-[4-(1,1-dioxoisothiazolidin-2-yl)phenyl]-valeramide and other compounds as inhibitors of coagulation factor Xa for treatment of thromboembolic diseases and tumuors. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7199133B2 (pt) |
| EP (1) | EP1441726B1 (pt) |
| JP (1) | JP4447909B2 (pt) |
| KR (1) | KR20050035165A (pt) |
| CN (1) | CN1582148A (pt) |
| AR (1) | AR037342A1 (pt) |
| AT (1) | ATE348611T1 (pt) |
| AU (1) | AU2002363366B2 (pt) |
| BR (1) | BR0213680A (pt) |
| CA (1) | CA2465713A1 (pt) |
| DE (2) | DE10155075A1 (pt) |
| DK (1) | DK1441726T3 (pt) |
| ES (1) | ES2277623T3 (pt) |
| HU (1) | HUP0401983A2 (pt) |
| MX (1) | MXPA04004307A (pt) |
| MY (1) | MY134079A (pt) |
| PL (1) | PL369737A1 (pt) |
| PT (1) | PT1441726E (pt) |
| RU (1) | RU2301228C2 (pt) |
| WO (1) | WO2003039543A1 (pt) |
| ZA (1) | ZA200404549B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2416384A1 (en) * | 2000-07-17 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, their production and use |
| US20040152741A1 (en) * | 2002-09-09 | 2004-08-05 | Nps Allelix Corporation | Arylglycine derivatives and their use as glycine transport inhibitors |
| CA2507026A1 (en) * | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, their production and use |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| TWI396686B (zh) * | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| DE102004054847A1 (de) * | 2004-11-13 | 2006-05-24 | Sanofi-Aventis Deutschland Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| KR101009594B1 (ko) * | 2007-05-09 | 2011-01-20 | 주식회사 레고켐 바이오사이언스 | Ｐ4 위치에 사이클릭 아미딘을 가지는 ＦＸａ 저해제, 이의유도체, 제조방법 및 이를 함유하는 의약 조성물 |
| PT2193196T (pt) * | 2007-09-28 | 2016-10-24 | Portola Pharm Inc | Antídotos para inibidores do fator xa e métodos de utilização dos mesmos |
| CN105101959B (zh) | 2012-11-05 | 2018-04-17 | 南特知识产权控股有限责任公司 | 作为刺猬信号传导通路的抑制剂的含有环状磺酰胺的衍生物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| US5300523A (en) | 1988-07-28 | 1994-04-05 | Bayer Aktiengesellschaft | Substituted aminomethyltetralins and their heterocyclic analogues |
| PT655996E (pt) * | 1992-08-19 | 2002-04-29 | Pfizer | Benzilaminas substituidas contendo heterociclicos nao aromaticos contendo azoto |
| US5550139A (en) | 1994-01-03 | 1996-08-27 | The Wichita State University | Serine protease inhibitors |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| US6489300B1 (en) | 1997-07-31 | 2002-12-03 | Eugene D. Thorsett | Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| AR016133A1 (es) | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
| DE19751949A1 (de) * | 1997-11-24 | 1999-05-27 | Bayer Ag | Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration |
| DE19754573A1 (de) * | 1997-12-09 | 1999-06-10 | Bayer Ag | Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma |
| DE19804085A1 (de) * | 1998-02-03 | 1999-08-05 | Boehringer Ingelheim Pharma | 5-Gliedrige heterocyclische kondensierte Benzoderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| US6114532A (en) | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| JP4619545B2 (ja) * | 1999-03-17 | 2011-01-26 | アストラゼネカ アクチボラグ | アミド誘導体 |
| EP1254136A4 (en) * | 2000-01-29 | 2005-06-01 | Lg Chem Investment Ltd | ARYLAMIDINES AND DERIVATIVES AS FACTOR XA INHIBITORS AND THEIR PRO-PHARMAKA |
| KR100423899B1 (ko) * | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| CZ20031028A3 (cs) | 2000-10-12 | 2003-08-13 | Merck & Co., Inc. | Aza- a polyazanaftalenylkarboxamidy |
| US6488154B1 (en) * | 2000-10-16 | 2002-12-03 | Ming-Chuan Yeh | Chip tray |
-
2001
- 2001-11-09 DE DE10155075A patent/DE10155075A1/de not_active Withdrawn
-
2002
- 2002-10-10 AU AU2002363366A patent/AU2002363366B2/en not_active Ceased
- 2002-10-10 US US10/495,254 patent/US7199133B2/en not_active Expired - Fee Related
- 2002-10-10 PL PL02369737A patent/PL369737A1/xx unknown
- 2002-10-10 PT PT02802623T patent/PT1441726E/pt unknown
- 2002-10-10 WO PCT/EP2002/011349 patent/WO2003039543A1/de active IP Right Grant
- 2002-10-10 CA CA002465713A patent/CA2465713A1/en not_active Abandoned
- 2002-10-10 AT AT02802623T patent/ATE348611T1/de not_active IP Right Cessation
- 2002-10-10 BR BR0213680-5A patent/BR0213680A/pt not_active IP Right Cessation
- 2002-10-10 CN CNA028219198A patent/CN1582148A/zh active Pending
- 2002-10-10 DE DE50209031T patent/DE50209031D1/de not_active Expired - Lifetime
- 2002-10-10 DK DK02802623T patent/DK1441726T3/da active
- 2002-10-10 MX MXPA04004307A patent/MXPA04004307A/es unknown
- 2002-10-10 EP EP02802623A patent/EP1441726B1/de not_active Expired - Lifetime
- 2002-10-10 ES ES02802623T patent/ES2277623T3/es not_active Expired - Lifetime
- 2002-10-10 JP JP2003541834A patent/JP4447909B2/ja not_active Expired - Fee Related
- 2002-10-10 KR KR1020047005508A patent/KR20050035165A/ko not_active Application Discontinuation
- 2002-10-10 HU HU0401983A patent/HUP0401983A2/hu unknown
- 2002-10-10 RU RU2004117594/04A patent/RU2301228C2/ru not_active IP Right Cessation
- 2002-11-06 MY MYPI20024148A patent/MY134079A/en unknown
- 2002-11-08 AR ARP020104288A patent/AR037342A1/es unknown
-
2004
- 2004-06-08 ZA ZA200404549A patent/ZA200404549B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2465713A1 (en) | 2003-05-15 |
| EP1441726B1 (de) | 2006-12-20 |
| AR037342A1 (es) | 2004-11-03 |
| RU2004117594A (ru) | 2006-01-10 |
| JP4447909B2 (ja) | 2010-04-07 |
| AU2002363366B2 (en) | 2007-11-22 |
| DE10155075A1 (de) | 2003-05-22 |
| US20040254175A1 (en) | 2004-12-16 |
| DE50209031D1 (de) | 2007-02-01 |
| BR0213680A (pt) | 2004-10-26 |
| ATE348611T1 (de) | 2007-01-15 |
| RU2301228C2 (ru) | 2007-06-20 |
| MY134079A (en) | 2007-11-30 |
| CN1582148A (zh) | 2005-02-16 |
| KR20050035165A (ko) | 2005-04-15 |
| HUP0401983A2 (hu) | 2005-01-28 |
| ES2277623T3 (es) | 2007-07-16 |
| EP1441726A1 (de) | 2004-08-04 |
| PL369737A1 (en) | 2005-05-02 |
| WO2003039543A1 (de) | 2003-05-15 |
| PT1441726E (pt) | 2007-03-30 |
| DK1441726T3 (da) | 2007-04-10 |
| MXPA04004307A (es) | 2004-08-11 |
| JP2005522412A (ja) | 2005-07-28 |
| US7199133B2 (en) | 2007-04-03 |
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