PE20160548A1 - Sulfonamidas como moduladores de canales de sodio - Google Patents

Sulfonamidas como moduladores de canales de sodio

Info

Publication number
PE20160548A1
PE20160548A1 PE2016000077A PE2016000077A PE20160548A1 PE 20160548 A1 PE20160548 A1 PE 20160548A1 PE 2016000077 A PE2016000077 A PE 2016000077A PE 2016000077 A PE2016000077 A PE 2016000077A PE 20160548 A1 PE20160548 A1 PE 20160548A1
Authority
PE
Peru
Prior art keywords
sodium channel
sulfonamides
channel modulators
compounds
pharmaceutically acceptable
Prior art date
Application number
PE2016000077A
Other languages
English (en)
Inventor
Corey Anderson
Sara Sabina Hadida-Ruah
James Philip Johnson
Andreas P Termin
Vijayalaksmi Arumugam
Brian Richard Bear
Paul Krenitsky
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PE20160548A1 publication Critical patent/PE20160548A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

La invencion se refiere a compuestos de formula I o a sales farmaceuticamente aceptables de los mismos, donde R1 es H, Cl, entre otros; R2 es entre otros H, Cl, CN; R3 es entre otros H, F, Cl; R4 es H; R5, R5', R6, R6' y R7 son entre otros H, F; utiles como inhibidores de canales de sodio. La invencion tambien proporciona composiciones farmaceuticamente aceptables que comprenden los compuestos de la invencion y metodos de uso de las composiciones en el tratamiento de diversos trastornos, incluyendo dolor
PE2016000077A 2013-07-19 2014-07-18 Sulfonamidas como moduladores de canales de sodio PE20160548A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361856146P 2013-07-19 2013-07-19

Publications (1)

Publication Number Publication Date
PE20160548A1 true PE20160548A1 (es) 2016-05-21

Family

ID=51293175

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016000077A PE20160548A1 (es) 2013-07-19 2014-07-18 Sulfonamidas como moduladores de canales de sodio

Country Status (25)

Country Link
US (1) US11203571B2 (es)
EP (1) EP3022175B1 (es)
JP (1) JP6337109B2 (es)
KR (1) KR102215620B1 (es)
CN (1) CN105683157B (es)
AP (1) AP2016009023A0 (es)
AU (1) AU2014290411B2 (es)
BR (1) BR112016000825B1 (es)
CA (1) CA2918365C (es)
CL (1) CL2016000106A1 (es)
EC (1) ECSP16005566A (es)
ES (1) ES2654393T3 (es)
GE (1) GEP20207102B (es)
HK (1) HK1223604A1 (es)
HU (1) HUE037876T2 (es)
IL (1) IL243671B (es)
MX (1) MX364155B (es)
NO (1) NO2918662T3 (es)
PE (1) PE20160548A1 (es)
PH (1) PH12016500105A1 (es)
RU (1) RU2680401C2 (es)
SG (1) SG11201600383SA (es)
UA (1) UA119147C2 (es)
WO (1) WO2015010065A1 (es)
ZA (1) ZA201600380B (es)

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TWI631105B (zh) 2013-01-31 2018-08-01 維泰克斯製藥公司 作爲鈉通道調節劑之喹啉及喹噁啉醯胺
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UA119147C2 (uk) 2013-07-19 2019-05-10 Вертекс Фармасьютікалз Інкорпорейтед Сульфонаміди як модулятори натрієвих каналів
DK3080134T3 (en) 2013-12-13 2018-10-22 Vertex Pharma PRODRUGS OF PYRIDONAMIDS USED AS MODULATORS OF SODIUM CHANNELS
JOP20200001A1 (ar) 2017-07-11 2022-10-30 Vertex Pharma كاربوكسأميدات بوصفها معدلات لقنوات الصوديوم

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CN105683157B (zh) 2019-07-19
SG11201600383SA (en) 2016-02-26
MX364155B (es) 2019-04-12
HK1223604A1 (zh) 2017-08-04
AU2014290411B2 (en) 2018-11-15
PH12016500105A1 (en) 2016-04-18
RU2016105511A3 (es) 2018-04-25
EP3022175B1 (en) 2017-11-08
CA2918365A1 (en) 2015-01-22
GEAP202014060A (en) 2020-01-27
IL243671A0 (en) 2016-04-21
GEP20207102B (en) 2020-05-11
US11203571B2 (en) 2021-12-21
MX2016000646A (es) 2016-05-26
CA2918365C (en) 2021-09-07
BR112016000825A8 (pt) 2020-01-07
AP2016009023A0 (en) 2016-02-29
US20160152561A1 (en) 2016-06-02
JP6337109B2 (ja) 2018-06-06
KR102215620B1 (ko) 2021-02-16
NZ715751A (en) 2021-09-24
IL243671B (en) 2020-10-29
BR112016000825B1 (pt) 2023-04-25
EP3022175A1 (en) 2016-05-25
CL2016000106A1 (es) 2016-07-29
UA119147C2 (uk) 2019-05-10
ES2654393T3 (es) 2018-02-13
RU2016105511A (ru) 2017-08-24
HUE037876T2 (hu) 2018-09-28
BR112016000825A2 (pt) 2017-07-25
JP2016525122A (ja) 2016-08-22
KR20160032241A (ko) 2016-03-23
WO2015010065A1 (en) 2015-01-22
RU2680401C2 (ru) 2019-02-21
ZA201600380B (en) 2018-07-25
NO2918662T3 (es) 2018-01-06
ECSP16005566A (es) 2017-02-24
AU2014290411A1 (en) 2016-01-28
CN105683157A (zh) 2016-06-15

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