PE20151892A1 - Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas - Google Patents
Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricasInfo
- Publication number
- PE20151892A1 PE20151892A1 PE2015001352A PE2015001352A PE20151892A1 PE 20151892 A1 PE20151892 A1 PE 20151892A1 PE 2015001352 A PE2015001352 A PE 2015001352A PE 2015001352 A PE2015001352 A PE 2015001352A PE 20151892 A1 PE20151892 A1 PE 20151892A1
- Authority
- PE
- Peru
- Prior art keywords
- methods
- heterocycle
- viric
- diseases
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invencion se refiere a nuevos compuestos tetraciclicos sustituidos con heterociclo de Formula (I): y sales farmaceuticamente aceptables de los mismos, en la que A, A', R2, R3, R4 y R5 son como se han definido en el presente documento. La presente invencion tambien se refiere a composiciones que comprenden al menos un compuesto tetraciclico sustituido con heterociclo, y metodos de uso de los compuestos tetraciclicos Sustituidos con Heterociclo para tratar o prevenir la infeccion por el VHC en un paciente
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2013/000038 WO2014110687A1 (en) | 2013-01-16 | 2013-01-16 | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151892A1 true PE20151892A1 (es) | 2015-12-24 |
Family
ID=51208906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015001352A PE20151892A1 (es) | 2013-01-16 | 2013-12-31 | Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas |
Country Status (26)
Country | Link |
---|---|
US (1) | US9555038B2 (es) |
EP (1) | EP2945952B1 (es) |
JP (3) | JP6093451B2 (es) |
KR (1) | KR101748974B1 (es) |
CN (1) | CN105073755B (es) |
AP (1) | AP2015008625A0 (es) |
AR (1) | AR094496A1 (es) |
AU (1) | AU2013374112B2 (es) |
BR (1) | BR112015016325A2 (es) |
CA (1) | CA2898049C (es) |
CL (1) | CL2015001971A1 (es) |
CR (1) | CR20150378A (es) |
DO (1) | DOP2015000169A (es) |
EA (1) | EA030554B1 (es) |
EC (1) | ECSP15035530A (es) |
HK (1) | HK1211290A1 (es) |
IL (1) | IL239832A0 (es) |
MA (1) | MA38315B1 (es) |
MD (1) | MD20150075A2 (es) |
MX (1) | MX356203B (es) |
PE (1) | PE20151892A1 (es) |
PH (1) | PH12015501560A1 (es) |
SG (1) | SG11201505536RA (es) |
TN (1) | TN2015000293A1 (es) |
TW (1) | TW201441231A (es) |
WO (2) | WO2014110687A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014110687A1 (en) * | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
WO2016196932A1 (en) * | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Process for preparing substituted tetracyclic heterocycle compounds |
WO2017023716A1 (en) * | 2015-08-04 | 2017-02-09 | Merck Sharp & Dohme Corp. | Fixed-dose combinations of antiviral compounds |
WO2017023714A1 (en) * | 2015-08-04 | 2017-02-09 | Merck Sharp & Dohme Corp. | Fixed-dose combinations of antiviral compounds |
WO2017112531A1 (en) * | 2015-12-21 | 2017-06-29 | Merck Sharp & Dohme Corp. | Silane-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
WO2017181383A1 (en) | 2016-04-21 | 2017-10-26 | Merck Sharp & Dohme Corp. | Hepatitis c virus inhibitors |
CN107522716B (zh) * | 2016-06-21 | 2021-02-02 | 浙江柏拉阿图医药科技有限公司 | 丙型肝炎病毒抑制剂及应用 |
WO2018032468A1 (en) * | 2016-08-18 | 2018-02-22 | Merck Sharp & Dohme Corp. | Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
WO2018032467A1 (en) * | 2016-08-18 | 2018-02-22 | Merck Sharp & Dohme Corp. | Chromane-substitued tetracyclic compounds and uses thereof for treatment of viral diseases |
CN109206396B (zh) * | 2017-07-05 | 2023-03-28 | 上海迪赛诺化学制药有限公司 | 2-c-甲基-4,5-o-(1-甲基乙烯基)-d-阿拉伯糖酸乙酯的制备方法 |
CN109232612A (zh) * | 2017-07-11 | 2019-01-18 | 周龙兴 | 抑制丙肝病毒的化合物、药物组合物及其用途 |
WO2020086414A1 (en) * | 2018-10-26 | 2020-04-30 | Merck Sharp & Dohme Corp. | Formulations of antiviral compounds |
TW202317145A (zh) * | 2021-06-17 | 2023-05-01 | 美商亞堤製藥公司 | 有利之抗hcv組合療法 |
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JP3927630B2 (ja) | 1996-09-27 | 2007-06-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウイルス感染症の予防・治療剤 |
PL359920A1 (en) | 2000-09-20 | 2004-09-06 | Merck Patent Gmbh | 4-amino-quinazolines |
JP2007516191A (ja) | 2003-07-10 | 2007-06-21 | パラダイム・セラピューティクス・リミテッド | ケイ素化合物およびその使用 |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
PT1719773E (pt) | 2004-02-24 | 2009-06-03 | Japan Tobacco Inc | Compostos heterotetracíclicos fundidos e a sua utilização como inibidores da polimerase do hcv |
WO2007084413A2 (en) | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
MX2007004979A (es) | 2004-10-26 | 2007-06-14 | Angeletti P Ist Richerche Bio | Derivados de indol tetraciclicos como agentes antiviricos. |
GB2438802A (en) | 2005-02-28 | 2007-12-05 | Univ Rockefeller | Structure of the hepatitis C virus NS5A protein |
US7994360B2 (en) | 2005-05-16 | 2011-08-09 | Xtl Biopharmaceuticals Ltd. | Benzofuran compounds |
US20110104109A1 (en) | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
AU2006267077A1 (en) | 2005-07-14 | 2007-01-18 | Irm Llc | Heterotetracyclic compounds as TPO mimetics |
US7473784B2 (en) | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
FR2894963A1 (fr) | 2005-12-16 | 2007-06-22 | Inst Nat Sante Rech Med | Nouveaux composes interagissant avec pea-15 |
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US20110130361A1 (en) | 2007-08-09 | 2011-06-02 | Jonathan Grimm | Silicon derivatives as histone deacetylase inhibitors |
JP2010535773A (ja) | 2007-08-10 | 2010-11-25 | グラクソスミスクライン エルエルシー | ウイルス感染を治療するための窒素含有二環式化学物質 |
PT2242752E (pt) | 2008-02-13 | 2012-10-29 | Bristol Myers Squibb Co | Imidazolil bifenil imidazóis como inibidores do vírus da hepatite c |
US7704992B2 (en) | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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WO2010041687A1 (ja) | 2008-10-09 | 2010-04-15 | コニカミノルタホールディングス株式会社 | 有機光電変換素子、太陽電池及び光センサアレイ |
US8729077B2 (en) | 2008-11-28 | 2014-05-20 | Glaxosmithkline Llc | Anti-viral compounds, compositions, and methods of use |
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JP5913091B2 (ja) * | 2009-03-27 | 2016-04-27 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | C型肝炎ウイルス複製の阻害剤 |
WO2010111617A2 (en) | 2009-03-27 | 2010-09-30 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
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JP2012528194A (ja) | 2009-05-29 | 2012-11-12 | メルク・シャープ・アンド・ドーム・コーポレーション | C型肝炎などの疾患を処置するための3つの整列型アリール部分で構成された抗菌性化合物 |
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US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CA2785488A1 (en) | 2009-12-22 | 2011-07-21 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
MA34147B1 (fr) | 2010-03-09 | 2013-04-03 | Merck Sharp & Dohme | Composes tricycliques fusionnes de silyle et leurs methodes d'utilisation dans le cadre du traitement de maladies virales |
WO2012040923A1 (en) * | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Tetracyclic indole derivatives and methods of use thereof for the treatment of viral diseases |
WO2012050850A1 (en) * | 2010-09-29 | 2012-04-19 | Merck Sharp & Dohme Corp. | Polycyclic heterocycle derivatives and methods of use thereof for the treatment of viral diseases |
BR112013007696A2 (pt) * | 2010-09-29 | 2019-09-24 | Merck Sharp & Dohme | composto, composição farmacêutica, usos do referido composto e da referida composição |
WO2014110687A1 (en) * | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
WO2014110688A1 (en) * | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiophene- sub stitued tetracyclic compounds and methods of use thereof for the treatment of viral diseases |
-
2013
- 2013-01-16 WO PCT/CN2013/000038 patent/WO2014110687A1/en active Application Filing
- 2013-12-31 PE PE2015001352A patent/PE20151892A1/es not_active Application Discontinuation
- 2013-12-31 WO PCT/CN2013/001676 patent/WO2014110705A1/en active Application Filing
- 2013-12-31 EP EP13871363.1A patent/EP2945952B1/en active Active
- 2013-12-31 AP AP2015008625A patent/AP2015008625A0/xx unknown
- 2013-12-31 US US14/761,256 patent/US9555038B2/en active Active
- 2013-12-31 AU AU2013374112A patent/AU2013374112B2/en not_active Ceased
- 2013-12-31 CA CA2898049A patent/CA2898049C/en not_active Expired - Fee Related
- 2013-12-31 EA EA201591328A patent/EA030554B1/ru not_active IP Right Cessation
- 2013-12-31 JP JP2015551946A patent/JP6093451B2/ja not_active Expired - Fee Related
- 2013-12-31 KR KR1020157021818A patent/KR101748974B1/ko active IP Right Grant
- 2013-12-31 SG SG11201505536RA patent/SG11201505536RA/en unknown
- 2013-12-31 MX MX2015009225A patent/MX356203B/es active IP Right Grant
- 2013-12-31 MD MDA20150075A patent/MD20150075A2/ro not_active Application Discontinuation
- 2013-12-31 BR BR112015016325A patent/BR112015016325A2/pt not_active Application Discontinuation
- 2013-12-31 MA MA38315A patent/MA38315B1/fr unknown
- 2013-12-31 CN CN201380074735.2A patent/CN105073755B/zh not_active Expired - Fee Related
-
2014
- 2014-01-16 AR ARP140100153A patent/AR094496A1/es unknown
- 2014-01-16 TW TW103101674A patent/TW201441231A/zh unknown
-
2015
- 2015-06-29 TN TNP2015000293A patent/TN2015000293A1/fr unknown
- 2015-07-08 IL IL239832A patent/IL239832A0/en unknown
- 2015-07-13 CL CL2015001971A patent/CL2015001971A1/es unknown
- 2015-07-13 PH PH12015501560A patent/PH12015501560A1/en unknown
- 2015-07-16 CR CR20150378A patent/CR20150378A/es unknown
- 2015-07-16 DO DO2015000169A patent/DOP2015000169A/es unknown
- 2015-08-17 EC ECIEPI201535530A patent/ECSP15035530A/es unknown
- 2015-12-08 HK HK15112117.6A patent/HK1211290A1/xx unknown
-
2016
- 2016-11-07 JP JP2016217169A patent/JP6148779B2/ja not_active Expired - Fee Related
- 2016-11-18 JP JP2016225137A patent/JP6417380B2/ja not_active Expired - Fee Related
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