SG11201505536RA - Heterocycle-substituted tetracyclic compounds and methods of use thereof for treatment of viral diseases - Google Patents

Heterocycle-substituted tetracyclic compounds and methods of use thereof for treatment of viral diseases

Info

Publication number
SG11201505536RA
SG11201505536RA SG11201505536RA SG11201505536RA SG11201505536RA SG 11201505536R A SG11201505536R A SG 11201505536RA SG 11201505536R A SG11201505536R A SG 11201505536RA SG 11201505536R A SG11201505536R A SG 11201505536RA SG 11201505536R A SG11201505536R A SG 11201505536RA
Authority
SG
Singapore
Prior art keywords
heterocycle
treatment
methods
viral diseases
tetracyclic compounds
Prior art date
Application number
SG11201505536RA
Inventor
Wensheng Yu
Ling Tong
Joseph A Kozlowski
Oleg Selyutin
Lei Chen
Jae-Hun Kim
Deyou Sha
Razia Rizvi
Bandarpalle Shankar
Bin Hu
Bin Zhong
Dahai Wang
Jinglai Hao
Wei Wei
Tao Ji
shuai Zan
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SG11201505536RA publication Critical patent/SG11201505536RA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201505536RA 2013-01-16 2013-12-31 Heterocycle-substituted tetracyclic compounds and methods of use thereof for treatment of viral diseases SG11201505536RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2013/000038 WO2014110687A1 (en) 2013-01-16 2013-01-16 Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases
PCT/CN2013/001676 WO2014110705A1 (en) 2013-01-16 2013-12-31 Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases

Publications (1)

Publication Number Publication Date
SG11201505536RA true SG11201505536RA (en) 2015-08-28

Family

ID=51208906

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505536RA SG11201505536RA (en) 2013-01-16 2013-12-31 Heterocycle-substituted tetracyclic compounds and methods of use thereof for treatment of viral diseases

Country Status (26)

Country Link
US (1) US9555038B2 (en)
EP (1) EP2945952B1 (en)
JP (3) JP6093451B2 (en)
KR (1) KR101748974B1 (en)
CN (1) CN105073755B (en)
AP (1) AP2015008625A0 (en)
AR (1) AR094496A1 (en)
AU (1) AU2013374112B2 (en)
BR (1) BR112015016325A2 (en)
CA (1) CA2898049C (en)
CL (1) CL2015001971A1 (en)
CR (1) CR20150378A (en)
DO (1) DOP2015000169A (en)
EA (1) EA030554B1 (en)
EC (1) ECSP15035530A (en)
HK (1) HK1211290A1 (en)
IL (1) IL239832A0 (en)
MA (1) MA38315B1 (en)
MD (1) MD20150075A2 (en)
MX (1) MX356203B (en)
PE (1) PE20151892A1 (en)
PH (1) PH12015501560A1 (en)
SG (1) SG11201505536RA (en)
TN (1) TN2015000293A1 (en)
TW (1) TW201441231A (en)
WO (2) WO2014110687A1 (en)

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US20180228826A1 (en) * 2015-08-04 2018-08-16 Merck Sharp & Dohme Corp. Fixed-dose combinations of antiviral compounds
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EP3393585A4 (en) * 2015-12-21 2019-05-08 Merck Sharp & Dohme Corp. Silane-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
WO2017181383A1 (en) 2016-04-21 2017-10-26 Merck Sharp & Dohme Corp. Hepatitis c virus inhibitors
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WO2018032468A1 (en) * 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases
WO2018032467A1 (en) 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Chromane-substitued tetracyclic compounds and uses thereof for treatment of viral diseases
CN109206396B (en) * 2017-07-05 2023-03-28 上海迪赛诺化学制药有限公司 Preparation method of 2-C-methyl-4,5-O- (1-methylvinyl) -D-arabinonic acid ethyl ester
CN109232612A (en) * 2017-07-11 2019-01-18 周龙兴 Inhibit compound, the medical composition and its use of hepatitis C virus
EP3870183A4 (en) * 2018-10-26 2022-07-20 Merck Sharp & Dohme Corp. Formulations of antiviral compounds
WO2022266497A1 (en) * 2021-06-17 2022-12-22 Atea Pharmaceuticals, Inc. Advantageous anti-hcv combination therapy

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Also Published As

Publication number Publication date
DOP2015000169A (en) 2015-12-31
US20150335648A1 (en) 2015-11-26
CA2898049C (en) 2018-04-17
MD20150075A2 (en) 2016-02-29
JP6093451B2 (en) 2017-03-08
JP2016510321A (en) 2016-04-07
ECSP15035530A (en) 2017-08-31
AR094496A1 (en) 2015-08-05
TW201441231A (en) 2014-11-01
IL239832A0 (en) 2015-08-31
JP2017095450A (en) 2017-06-01
MA38315A1 (en) 2017-02-28
EP2945952A4 (en) 2016-07-20
CL2015001971A1 (en) 2015-10-23
CR20150378A (en) 2015-12-09
WO2014110687A1 (en) 2014-07-24
MX356203B (en) 2018-05-18
EP2945952B1 (en) 2019-08-28
AU2013374112A1 (en) 2015-07-16
CN105073755B (en) 2017-08-18
AP2015008625A0 (en) 2015-07-31
MA38315B1 (en) 2018-05-31
JP2017075158A (en) 2017-04-20
TN2015000293A1 (en) 2016-10-03
PE20151892A1 (en) 2015-12-24
JP6148779B2 (en) 2017-06-14
EA201591328A1 (en) 2015-11-30
HK1211290A1 (en) 2016-05-20
EP2945952A1 (en) 2015-11-25
EA030554B1 (en) 2018-08-31
CA2898049A1 (en) 2014-07-24
PH12015501560A1 (en) 2015-09-21
AU2013374112B2 (en) 2016-11-17
WO2014110705A1 (en) 2014-07-24
WO2014110705A9 (en) 2015-03-05
US9555038B2 (en) 2017-01-31
JP6417380B2 (en) 2018-11-07
MX2015009225A (en) 2015-10-15
CN105073755A (en) 2015-11-18
KR20150104630A (en) 2015-09-15
KR101748974B1 (en) 2017-06-19
BR112015016325A2 (en) 2017-08-22

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