MX356203B - Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas. - Google Patents

Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas.

Info

Publication number
MX356203B
MX356203B MX2015009225A MX2015009225A MX356203B MX 356203 B MX356203 B MX 356203B MX 2015009225 A MX2015009225 A MX 2015009225A MX 2015009225 A MX2015009225 A MX 2015009225A MX 356203 B MX356203 B MX 356203B
Authority
MX
Mexico
Prior art keywords
heterocycle
substituted tetracyclic
methods
treatment
tetracyclic compounds
Prior art date
Application number
MX2015009225A
Other languages
English (en)
Other versions
MX2015009225A (es
Inventor
Ling Tong
Lei Chen
Joseph A Kozlowski
Wensheng Yu
Razia Rizvi
Jae-Hun Kim
Bin Hu
Bin Zhong
Tao Ji
Deyou Sha
Jinglai Hao
Oleg Selyutin
Bandarpalle Shankar
Dahai Wang
Wei Wei
shuai Zan
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2015009225A publication Critical patent/MX2015009225A/es
Publication of MX356203B publication Critical patent/MX356203B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a nuevos Compuestos Tetracíclicos Sustituidos con Heterociclo de Fórmula (I): (Ver Fórmula) y sales farmacéuticamente aceptables de los mismos, en la que A, A1, R2, R3, R4 y R5 son como se han definido en el presente documento; la presente invención también se refiere a composiciones que comprenden al menos un Compuesto Tetracíclico Sustituido con Heterociclo, y métodos de uso de los Compuestos Tetracíclicos Sustituidos con Heterociclopara tratar o prevenir la infección por el VHC en un paciente.
MX2015009225A 2013-01-16 2013-12-31 Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas. MX356203B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2013/000038 WO2014110687A1 (en) 2013-01-16 2013-01-16 Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases
PCT/CN2013/001676 WO2014110705A1 (en) 2013-01-16 2013-12-31 Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases

Publications (2)

Publication Number Publication Date
MX2015009225A MX2015009225A (es) 2015-10-15
MX356203B true MX356203B (es) 2018-05-18

Family

ID=51208906

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015009225A MX356203B (es) 2013-01-16 2013-12-31 Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas.

Country Status (26)

Country Link
US (1) US9555038B2 (es)
EP (1) EP2945952B1 (es)
JP (3) JP6093451B2 (es)
KR (1) KR101748974B1 (es)
CN (1) CN105073755B (es)
AP (1) AP2015008625A0 (es)
AR (1) AR094496A1 (es)
AU (1) AU2013374112B2 (es)
BR (1) BR112015016325A2 (es)
CA (1) CA2898049C (es)
CL (1) CL2015001971A1 (es)
CR (1) CR20150378A (es)
DO (1) DOP2015000169A (es)
EA (1) EA030554B1 (es)
EC (1) ECSP15035530A (es)
HK (1) HK1211290A1 (es)
IL (1) IL239832A0 (es)
MA (1) MA38315B1 (es)
MD (1) MD20150075A2 (es)
MX (1) MX356203B (es)
PE (1) PE20151892A1 (es)
PH (1) PH12015501560A1 (es)
SG (1) SG11201505536RA (es)
TN (1) TN2015000293A1 (es)
TW (1) TW201441231A (es)
WO (2) WO2014110687A1 (es)

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WO2017023714A1 (en) * 2015-08-04 2017-02-09 Merck Sharp & Dohme Corp. Fixed-dose combinations of antiviral compounds
WO2017023716A1 (en) * 2015-08-04 2017-02-09 Merck Sharp & Dohme Corp. Fixed-dose combinations of antiviral compounds
US20190002480A1 (en) * 2015-12-21 2019-01-03 Merck Sharp & Dohme Corp. Silane-Containing Heterocyclic Compounds and Methods of Use Thereof for the Treatment of Viral Diseases
WO2017181383A1 (en) 2016-04-21 2017-10-26 Merck Sharp & Dohme Corp. Hepatitis c virus inhibitors
CN107522716B (zh) * 2016-06-21 2021-02-02 浙江柏拉阿图医药科技有限公司 丙型肝炎病毒抑制剂及应用
WO2018032468A1 (en) * 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases
WO2018032467A1 (en) 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Chromane-substitued tetracyclic compounds and uses thereof for treatment of viral diseases
CN109206396B (zh) * 2017-07-05 2023-03-28 上海迪赛诺化学制药有限公司 2-c-甲基-4,5-o-(1-甲基乙烯基)-d-阿拉伯糖酸乙酯的制备方法
CN109232612A (zh) * 2017-07-11 2019-01-18 周龙兴 抑制丙肝病毒的化合物、药物组合物及其用途
WO2020086414A1 (en) * 2018-10-26 2020-04-30 Merck Sharp & Dohme Corp. Formulations of antiviral compounds
TW202317145A (zh) * 2021-06-17 2023-05-01 美商亞堤製藥公司 有利之抗hcv組合療法

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Also Published As

Publication number Publication date
IL239832A0 (en) 2015-08-31
PE20151892A1 (es) 2015-12-24
EP2945952A1 (en) 2015-11-25
CN105073755A (zh) 2015-11-18
MA38315A1 (fr) 2017-02-28
WO2014110705A9 (en) 2015-03-05
MA38315B1 (fr) 2018-05-31
US9555038B2 (en) 2017-01-31
MX2015009225A (es) 2015-10-15
CL2015001971A1 (es) 2015-10-23
EA201591328A1 (ru) 2015-11-30
MD20150075A2 (ro) 2016-02-29
KR101748974B1 (ko) 2017-06-19
BR112015016325A2 (pt) 2017-08-22
WO2014110705A1 (en) 2014-07-24
TW201441231A (zh) 2014-11-01
AP2015008625A0 (en) 2015-07-31
SG11201505536RA (en) 2015-08-28
JP6417380B2 (ja) 2018-11-07
JP6093451B2 (ja) 2017-03-08
EA030554B1 (ru) 2018-08-31
EP2945952B1 (en) 2019-08-28
DOP2015000169A (es) 2015-12-31
ECSP15035530A (es) 2017-08-31
HK1211290A1 (en) 2016-05-20
CR20150378A (es) 2015-12-09
AU2013374112A1 (en) 2015-07-16
PH12015501560A1 (en) 2015-09-21
KR20150104630A (ko) 2015-09-15
JP6148779B2 (ja) 2017-06-14
EP2945952A4 (en) 2016-07-20
TN2015000293A1 (en) 2016-10-03
JP2017095450A (ja) 2017-06-01
WO2014110687A1 (en) 2014-07-24
CN105073755B (zh) 2017-08-18
CA2898049A1 (en) 2014-07-24
JP2017075158A (ja) 2017-04-20
US20150335648A1 (en) 2015-11-26
AU2013374112B2 (en) 2016-11-17
AR094496A1 (es) 2015-08-05
JP2016510321A (ja) 2016-04-07
CA2898049C (en) 2018-04-17

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