NZ631726A - Therapeutic compounds for the treatment of viral infections - Google Patents

Therapeutic compounds for the treatment of viral infections

Info

Publication number
NZ631726A
NZ631726A NZ631726A NZ63172614A NZ631726A NZ 631726 A NZ631726 A NZ 631726A NZ 631726 A NZ631726 A NZ 631726A NZ 63172614 A NZ63172614 A NZ 63172614A NZ 631726 A NZ631726 A NZ 631726A
Authority
NZ
New Zealand
Prior art keywords
formula
treatment
viral infections
therapeutic compounds
compounds
Prior art date
Application number
NZ631726A
Inventor
John O Link
Steven S Bondy
Carina E Cannizzaro
Chien-Hung Chou
Yunfeng Eric Hu
Qi Liu
Scott D Schroeder
Winston C Tse
Jennifer R Zhang
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority to NZ727792A priority Critical patent/NZ727792A/en
Publication of NZ631726A publication Critical patent/NZ631726A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Disclosed are compounds of formula I, wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
NZ631726A 2013-01-09 2014-01-09 Therapeutic compounds for the treatment of viral infections NZ631726A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ727792A NZ727792A (en) 2013-01-09 2014-01-09 Therapeutic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361750759P 2013-01-09 2013-01-09
PCT/US2014/010937 WO2014110296A1 (en) 2013-01-09 2014-01-09 Therapeutic compounds for the treatment of viral infections

Publications (1)

Publication Number Publication Date
NZ631726A true NZ631726A (en) 2017-01-27

Family

ID=50023885

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ727792A NZ727792A (en) 2013-01-09 2014-01-09 Therapeutic compounds
NZ631726A NZ631726A (en) 2013-01-09 2014-01-09 Therapeutic compounds for the treatment of viral infections

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NZ727792A NZ727792A (en) 2013-01-09 2014-01-09 Therapeutic compounds

Country Status (12)

Country Link
US (1) US9012441B2 (en)
EP (1) EP2943493B1 (en)
JP (1) JP5860197B1 (en)
AU (1) AU2014205315B2 (en)
CA (1) CA2897268C (en)
ES (1) ES2642265T3 (en)
HK (1) HK1216421A1 (en)
NZ (2) NZ727792A (en)
PL (1) PL2943493T3 (en)
PT (1) PT2943493T (en)
SI (1) SI2943493T1 (en)
WO (1) WO2014110296A1 (en)

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TWI694071B (en) 2013-03-01 2020-05-21 美商基利科學股份有限公司 Therapeutic compounds for treating a retroviridae viral infection
US10202353B2 (en) 2014-02-28 2019-02-12 Gilead Sciences, Inc. Therapeutic compounds
EP3186239B1 (en) 2014-08-29 2018-10-10 Gilead Sciences, Inc. Antiretroviral agents
AU2015370004B2 (en) 2014-12-26 2021-03-11 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
LT3597646T (en) 2016-08-19 2023-09-25 Gilead Sciences, Inc. Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection
UY37710A (en) 2017-05-02 2018-11-30 Viiv Healthcare Uk No 5 Ltd INHIBITORS OF THE HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
AR112412A1 (en) 2017-08-17 2019-10-23 Gilead Sciences Inc CHOLINE SALT FORMS OF AN HIV CAPSID INHIBITOR
TWI687415B (en) 2017-08-17 2020-03-11 美商基利科學股份有限公司 Solid forms of an hiv capsid inhibitor
SG11202004403QA (en) 2017-12-07 2020-06-29 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
US10836746B2 (en) 2018-02-15 2020-11-17 Gilead Sciences, Inc. Therapeutic compounds
AR114631A1 (en) 2018-02-16 2020-09-30 Gilead Sciences Inc METHODS AND INTERMEDIATES FOR PREPARING PYRIDINE COMPOUNDS
ES2962736T3 (en) 2018-04-11 2024-05-24 Viiv Healthcare Uk No 5 Ltd 4-oxo-3,4-dihydroquinazoline compounds as inhibitors of human immunodeficiency virus replication
KR20230141905A (en) 2018-07-16 2023-10-10 길리애드 사이언시즈, 인코포레이티드 Capsid inhibitors for the treatment of hiv
US11958834B2 (en) 2018-08-09 2024-04-16 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
US20220089598A1 (en) 2018-09-14 2022-03-24 Viiv Healthcare Uk (No. 5) Limited Inhibitors of human immunodeficiency virus replication
JP7433303B2 (en) 2018-09-20 2024-02-19 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Inhibitor of human immunodeficiency virus replication
PE20211781A1 (en) 2018-10-24 2021-09-08 Viiv Healthcare Uk No 5 Ltd HUMAN IMMUNODEFICIENCY VIRUS REPLICATION INHIBITORS
JP7532354B2 (en) 2018-10-24 2024-08-13 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Inhibitors of human immunodeficiency virus replication
JP7500555B2 (en) 2018-10-25 2024-06-17 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Inhibitors of human immunodeficiency virus replication
US20210403465A1 (en) 2018-10-29 2021-12-30 VIIV Healthcare UK (No.5) Limited Quinazolinyl-indazole derivatives and their use as inhibitors of human immunodeficiency virus replication
EP3877387A1 (en) 2018-11-05 2021-09-15 ViiV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
WO2020095176A1 (en) 2018-11-05 2020-05-14 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
EP3903788A4 (en) * 2018-12-27 2022-09-07 Taisho Pharmaceutical Co., Ltd. Pyrazolo[1,5-a]pyrimidine macrocyclic compound
UY38559A (en) 2019-02-01 2020-07-31 Viiv Healthcare Uk No 5 Ltd HUMAN IMMUNODEFICIENCY VIRUS REPLICATION INHIBITORS
JP7545414B2 (en) 2019-04-30 2024-09-04 ビーブ、ヘルスケア、ユーケー、（ナンバー５）、リミテッド Human immunodeficiency virus replication inhibitors
CR20210664A (en) 2019-06-19 2022-01-21 Viiv Healthcare Uk No 5 Ltd Pyrido[2,3-d]pyrimidine derivatives as inhibitors of human immunodeficiency virus replication
JP2022551254A (en) 2019-10-01 2022-12-08 ビーブ、ヘルスケア、ユーケー、（ナンバー５）、リミテッド Replication inhibitor of human immunodeficiency virus
WO2021064570A1 (en) 2019-10-01 2021-04-08 VIIV Healthcare UK (No.5) Limited N-substututed-6-oxo-1,6-dihydropyrimidine-2-yl derivatives as inhibitors of the human immunodeficiency virus replication
TW202128648A (en) 2019-10-04 2021-08-01 英商Ｖｉｉｖ醫療保健英國(Ｎｏ 5)有限公司 Inhibitors of human immunodeficiency virus replication
US20220370451A1 (en) 2019-10-08 2022-11-24 VIIV HEALTHCARE UK ( No. 5) LIMITED Inhibitors of human immunodeficiency virus replication
KR20220106165A (en) 2019-11-26 2022-07-28 길리애드 사이언시즈, 인코포레이티드 Capsid inhibitors for the prevention of HIV
EP4066839A4 (en) 2019-11-28 2023-12-27 Shionogi & Co., Ltd Prophylactic and therapeutic pharmaceutical agent for hiv infectious diseases characterized by comprising combination of integrase inhibitor and anti-hiv agent
IL296182A (en) 2020-03-06 2022-11-01 Viiv Healthcare Uk No 5 Ltd Inhibitors of human immunodeficiency virus replication
WO2021176367A1 (en) 2020-03-06 2021-09-10 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
CN115397424A (en) 2020-04-15 2022-11-25 Viiv保健英国第五有限公司 Inhibitors of human immunodeficiency virus replication
TW202208362A (en) 2020-06-25 2022-03-01 美商基利科學股份有限公司 Capsid inhibitors for the treatment of hiv
AU2022399845A1 (en) 2021-12-03 2024-05-23 Gilead Sciences, Inc. Therapeutic compounds for hiv virus infection
TW202412779A (en) 2021-12-03 2024-04-01 美商基利科學股份有限公司 Therapeutic compounds for hiv virus infection

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US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
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PT2588450T (en) 2010-07-02 2017-08-03 Gilead Sciences Inc Napht-2-ylacetic acid derivatives to treat aids
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ES2553449T3 (en) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compounds for HIV treatment
CN102863512B (en) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 Antiviral compound
TWI480271B (en) 2012-04-20 2015-04-11 Gilead Sciences Inc Therapeutic compounds
GB201213087D0 (en) 2012-07-24 2012-09-05 Medical Res Council Inhibition of HIV-1 infection
TW201443037A (en) 2013-01-09 2014-11-16 Gilead Sciences Inc Therapeutic compounds
AU2014205317B2 (en) 2013-01-09 2016-11-24 Gilead Sciences, Inc. 5-membered heteroaryls and their use as antiviral agents

Also Published As

Publication number Publication date
JP2016508150A (en) 2016-03-17
US20140221417A1 (en) 2014-08-07
AU2014205315A1 (en) 2015-07-16
ES2642265T3 (en) 2017-11-16
EP2943493A1 (en) 2015-11-18
AU2014205315B2 (en) 2016-11-17
HK1216421A1 (en) 2016-11-11
SI2943493T1 (en) 2017-11-30
WO2014110296A1 (en) 2014-07-17
CA2897268C (en) 2018-12-04
US9012441B2 (en) 2015-04-21
PT2943493T (en) 2017-10-23
CA2897268A1 (en) 2014-07-17
EP2943493B1 (en) 2017-08-02
PL2943493T3 (en) 2017-12-29
JP5860197B1 (en) 2016-02-16
NZ727792A (en) 2018-04-27

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Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 09 JAN 2019 BY COMPUTER PACKAGES INC

Effective date: 20171219

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 09 JAN 2020 BY COMPUTER PACKAGES INC

Effective date: 20181218

LAPS Patent lapsed