MA38315B1 - Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales - Google Patents

Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales

Info

Publication number
MA38315B1
MA38315B1 MA38315A MA38315A MA38315B1 MA 38315 B1 MA38315 B1 MA 38315B1 MA 38315 A MA38315 A MA 38315A MA 38315 A MA38315 A MA 38315A MA 38315 B1 MA38315 B1 MA 38315B1
Authority
MA
Morocco
Prior art keywords
heterocycle
substituted tetracyclic
methods
treatment
tetracyclic compounds
Prior art date
Application number
MA38315A
Other languages
English (en)
Other versions
MA38315A1 (fr
Inventor
Wensheng Yu
Ling Tong
Joseph A Kozlowski
Oleg Selyutin
Lei Chen
Jae-Hun Kim
Deyou Sha
Razia Rizvi
Bandarpalle Shankar
Bin Hu
Bin Zhong
Dahai Wang
Jinglai Hao
Wei Wei
Tao Ji
shuai Zan
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA38315A1 publication Critical patent/MA38315A1/fr
Publication of MA38315B1 publication Critical patent/MA38315B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La présente invention concerne de nouveaux composés tétracycliques substitués par un hétérocycle de formule (i): (i) et leurs sels pharmaceutiquement acceptables, où a, a', r2, r3, r4 et r sont définis ici. La présente invention concerne également des compositions comprenant au moins un composé tétracyclique substitué par un hétérocycle et des procédés d'utilisation des composés tétracycliques substitués par un hétérocycle pour traiter ou prévenir une infection par le vhc chez un patient.
MA38315A 2013-01-16 2013-12-31 Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales MA38315B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2013/000038 WO2014110687A1 (fr) 2013-01-16 2013-01-16 Composés tétracycliques substitués par thiazolyle et leurs procédés d'utilisation pour le traitement de maladies virales
PCT/CN2013/001676 WO2014110705A1 (fr) 2013-01-16 2013-12-31 Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales

Publications (2)

Publication Number Publication Date
MA38315A1 MA38315A1 (fr) 2017-02-28
MA38315B1 true MA38315B1 (fr) 2018-05-31

Family

ID=51208906

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38315A MA38315B1 (fr) 2013-01-16 2013-12-31 Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales

Country Status (26)

Country Link
US (1) US9555038B2 (fr)
EP (1) EP2945952B1 (fr)
JP (3) JP6093451B2 (fr)
KR (1) KR101748974B1 (fr)
CN (1) CN105073755B (fr)
AP (1) AP2015008625A0 (fr)
AR (1) AR094496A1 (fr)
AU (1) AU2013374112B2 (fr)
BR (1) BR112015016325A2 (fr)
CA (1) CA2898049C (fr)
CL (1) CL2015001971A1 (fr)
CR (1) CR20150378A (fr)
DO (1) DOP2015000169A (fr)
EA (1) EA030554B1 (fr)
EC (1) ECSP15035530A (fr)
HK (1) HK1211290A1 (fr)
IL (1) IL239832A0 (fr)
MA (1) MA38315B1 (fr)
MD (1) MD20150075A2 (fr)
MX (1) MX356203B (fr)
PE (1) PE20151892A1 (fr)
PH (1) PH12015501560A1 (fr)
SG (1) SG11201505536RA (fr)
TN (1) TN2015000293A1 (fr)
TW (1) TW201441231A (fr)
WO (2) WO2014110687A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110687A1 (fr) * 2013-01-16 2014-07-24 Merck Sharp & Dohme Corp. Composés tétracycliques substitués par thiazolyle et leurs procédés d'utilisation pour le traitement de maladies virales
WO2016196932A1 (fr) * 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Procédé de préparation de composés hétérocycliques tétracycliques substitués
WO2017023716A1 (fr) * 2015-08-04 2017-02-09 Merck Sharp & Dohme Corp. Combinaisons à dose fixe de composés antiviraux
WO2017023714A1 (fr) * 2015-08-04 2017-02-09 Merck Sharp & Dohme Corp. Combinaisons à dose fixée de composés antiviraux
US20190002480A1 (en) * 2015-12-21 2019-01-03 Merck Sharp & Dohme Corp. Silane-Containing Heterocyclic Compounds and Methods of Use Thereof for the Treatment of Viral Diseases
WO2017181383A1 (fr) 2016-04-21 2017-10-26 Merck Sharp & Dohme Corp. Inhibiteurs du virus de l'hépatite c
CN107522716B (zh) * 2016-06-21 2021-02-02 浙江柏拉阿图医药科技有限公司 丙型肝炎病毒抑制剂及应用
WO2018032467A1 (fr) 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Composés tétracycliques substitués par chromane et leurs utilisations dans le traitement de maladies virales
WO2018032468A1 (fr) 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Composés tétracycliques substitués par hétérocycles et leurs procédés d'utilisation pour le traitement de maladies virales
CN109206396B (zh) * 2017-07-05 2023-03-28 上海迪赛诺化学制药有限公司 2-c-甲基-4,5-o-(1-甲基乙烯基)-d-阿拉伯糖酸乙酯的制备方法
CN109232612A (zh) * 2017-07-11 2019-01-18 周龙兴 抑制丙肝病毒的化合物、药物组合物及其用途
WO2020086414A1 (fr) * 2018-10-26 2020-04-30 Merck Sharp & Dohme Corp. Formulations de composés antiviraux
WO2022266497A1 (fr) * 2021-06-17 2022-12-22 Atea Pharmaceuticals, Inc. Polythérapie anti-vhc avantageuse

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3927630B2 (ja) 1996-09-27 2007-06-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウイルス感染症の予防・治療剤
AU2001293817A1 (en) 2000-09-20 2002-04-02 Merck Patent Gmbh 4-amino-quinazolines
ES2291898T3 (es) 2003-07-10 2008-03-01 Takeda Cambridge Limited Compuestos de silicio y su utilizacion.
DE602005013922D1 (de) 2004-02-24 2009-05-28 Japan Tobacco Inc Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
WO2007084413A2 (fr) 2004-07-14 2007-07-26 Ptc Therapeutics, Inc. Procedes de traitement de l’hepatite c
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
JP2008517987A (ja) 2004-10-26 2008-05-29 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー 抗ウイルス薬としての四環式インドール誘導体
GB2438802A (en) 2005-02-28 2007-12-05 Univ Rockefeller Structure of the hepatitis C virus NS5A protein
US7994360B2 (en) 2005-05-16 2011-08-09 Xtl Biopharmaceuticals Ltd. Benzofuran compounds
US20110104109A1 (en) 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
PL1910338T3 (pl) 2005-07-14 2011-02-28 Irm Llc Związki heterotetracykliczne jako mimetyki TPO
US7473784B2 (en) 2005-08-01 2009-01-06 Bristol-Myers Squibb Company Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
FR2894963A1 (fr) 2005-12-16 2007-06-22 Inst Nat Sante Rech Med Nouveaux composes interagissant avec pea-15
US7745636B2 (en) 2006-08-11 2010-06-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7642251B2 (en) 2007-08-09 2010-01-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
WO2009020589A1 (fr) 2007-08-09 2009-02-12 Merck & Co., Inc. Dérivés de silicium sous la forme d'inhibiteurs d'histone désacétylase
JP2010535773A (ja) 2007-08-10 2010-11-25 グラクソスミスクライン エルエルシー ウイルス感染を治療するための窒素含有二環式化学物質
SI2242752T1 (sl) 2008-02-13 2013-03-29 Bristol-Myers Squibb Company Imidazolil bifnil imidazoli kot hepatitis c virusni inhibitorji
US7704992B2 (en) 2008-02-13 2010-04-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
RS53420B (en) 2008-07-22 2014-12-31 Msd Italia S.R.L. MACROCYCLIC COMPOUNDS OF HINOXALINE, WHICH IS AN INHIBITOR OF HCV NS3 PROTEASES WITH OTHER HCV AGENTS
WO2010041687A1 (fr) 2008-10-09 2010-04-15 コニカミノルタホールディングス株式会社 Élément de conversion photoélectrique organique, cellule solaire, et réseau de capteurs optiques
WO2010062821A1 (fr) 2008-11-28 2010-06-03 Glaxosmithkline Llc Composés antiviraux, compositions, et procédés d’utilisation
BRPI0922366B8 (pt) 2008-12-03 2021-05-25 Presidio Pharmaceuticals Inc composto, composição farmacêutica e uso de um composto
EP2411038B1 (fr) 2009-03-27 2016-12-28 Van Andel Research Institute Peptides de l'hormone parathyroïdienne et peptides de la protéine apparentée à l'hormone parathyroïdienne ainsi que des procédés d'utilisation
UA108351C2 (uk) 2009-03-27 2015-04-27 Інгібітори реплікації вірусу гепатиту c
US9150554B2 (en) 2009-03-27 2015-10-06 Presidio Pharmaceuticals, Inc. Fused ring inhibitors of hepatitis C
CA2762885A1 (fr) 2009-05-29 2010-12-02 Schering Corporation Composes antiviraux constitues de trois fractions d'aryle alignees pour traiter des maladies telles que l'hepatite c
US8221737B2 (en) 2009-06-16 2012-07-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20130156731A1 (en) 2009-12-22 2013-06-20 Kevin X. Chen Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas
PE20130062A1 (es) 2010-03-09 2013-02-28 Merck Sharp & Dohme Compuestos de sililo triciclicos fusionados para el tratamiento de enfermedades virales
US20130280214A1 (en) * 2010-09-29 2013-10-24 Merck Sharp & Dohme Corp. Polycyclic heterocycle derivatives and methods of use thereof for the treatment of viral diseases
WO2012040923A1 (fr) * 2010-09-29 2012-04-05 Merck Sharp & Dohme Corp. Dérivés d'indoles tétracycliques et leurs méthodes d'utilisation pour le traitement de maladies virales
CA2811662A1 (fr) * 2010-09-29 2012-04-05 Merck Sharp & Dohme Corp. Derives d'indoles tetracycliques pour le traitement d'une infection par le virus de l'hepatite c
WO2014110688A1 (fr) * 2013-01-16 2014-07-24 Merck Sharp & Dohme Corp. Composés tétracycliques à substitution thiophène et leurs procédés d'utilisation pour le traitement des maladies virales
WO2014110687A1 (fr) 2013-01-16 2014-07-24 Merck Sharp & Dohme Corp. Composés tétracycliques substitués par thiazolyle et leurs procédés d'utilisation pour le traitement de maladies virales

Also Published As

Publication number Publication date
HK1211290A1 (en) 2016-05-20
AU2013374112A1 (en) 2015-07-16
AR094496A1 (es) 2015-08-05
SG11201505536RA (en) 2015-08-28
EP2945952A4 (fr) 2016-07-20
JP6148779B2 (ja) 2017-06-14
WO2014110705A1 (fr) 2014-07-24
TN2015000293A1 (en) 2016-10-03
JP2017075158A (ja) 2017-04-20
MD20150075A2 (ro) 2016-02-29
KR101748974B1 (ko) 2017-06-19
CR20150378A (es) 2015-12-09
ECSP15035530A (es) 2017-08-31
EA201591328A1 (ru) 2015-11-30
EA030554B1 (ru) 2018-08-31
MX356203B (es) 2018-05-18
CN105073755A (zh) 2015-11-18
MA38315A1 (fr) 2017-02-28
WO2014110705A9 (fr) 2015-03-05
CL2015001971A1 (es) 2015-10-23
BR112015016325A2 (pt) 2017-08-22
CA2898049C (fr) 2018-04-17
PE20151892A1 (es) 2015-12-24
AP2015008625A0 (en) 2015-07-31
WO2014110687A1 (fr) 2014-07-24
CN105073755B (zh) 2017-08-18
EP2945952B1 (fr) 2019-08-28
CA2898049A1 (fr) 2014-07-24
AU2013374112B2 (en) 2016-11-17
KR20150104630A (ko) 2015-09-15
MX2015009225A (es) 2015-10-15
IL239832A0 (en) 2015-08-31
US20150335648A1 (en) 2015-11-26
DOP2015000169A (es) 2015-12-31
US9555038B2 (en) 2017-01-31
JP6093451B2 (ja) 2017-03-08
TW201441231A (zh) 2014-11-01
EP2945952A1 (fr) 2015-11-25
JP6417380B2 (ja) 2018-11-07
JP2017095450A (ja) 2017-06-01
JP2016510321A (ja) 2016-04-07
PH12015501560A1 (en) 2015-09-21

Similar Documents

Publication Publication Date Title
MA38315B1 (fr) Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales
MA35109B1 (fr) Derives de nucleoside 2-substitues et procedes d'utilisation de ceux-ci pour le traitement de maladies virales
MA41134B1 (fr) Composés substitués de 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione pour le traitement et la prophylaxie des infections virales
MA37400B1 (fr) Composés hétérocyclyle en tant qu'inhibiteurs de mek
MA41338B1 (fr) Composés de pyrazine pour le traitement de maladies infectieuses
MA40225A (fr) Composés dihydroisoquinolinone substitués
MA37712B1 (fr) Inhibiteurs macrocycliques de virus flaviviridae
MX2010009995A (es) Heterociclos puenteados como inhibidores de la integrasa del virus de inmunodeficiencia humana.
MA46038B1 (fr) Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale
MA42410A (fr) Oxystérols et leurs méthodes d'utilisation
MA39211B1 (fr) Composés tricycliques comme agents anti-cancers
MA32135B1 (fr) Inhibiteurs de pim kinase et leurs procedes d'utilisation
MX2009008439A (es) Nuevos inhibidores de la replicacion del virus de hepatitis c.
MX2013005478A (es) Compuestos heterociclicos condensados antivirales.
MA33745B1 (fr) Piperidines substituees qui accroissent l'activite de p53, et utilisation de ces composes
MA34147B1 (fr) Composes tricycliques fusionnes de silyle et leurs methodes d'utilisation dans le cadre du traitement de maladies virales
MA34604B1 (fr) Derives de la pyrazine en tant que bloqueurs de l'enac
EA200802329A1 (ru) Производные триазола ii
EA200901241A1 (ru) Соединения для лечения гепатита с
MA37891B1 (fr) Alcoxypyrazoles comme activateurs de guanylate cyclase soluble
TN2016000188A1 (fr) Derives de purines 2,6-substitues et leur utilisation dans le traitement de troubles proliferatifs.
MA34547B1 (fr) Traitement d'association pour traiter une infection par le vhc
DE602007011434D1 (de) 1h-indol-5-ylpiperazin-1-ylmethanonderivate
DE602007001463D1 (de) Pyrimidin-, chinazolin-, pteridin- und triazinderivate
MA38009B1 (fr) Composes d'azaindoline substitues qui ont une activite inhibitrice de la proteine d'apoptose pour leurs utilisations dans le traitement et/ou la prophylaxie du cancer