MA35109B1 - Derives de nucleoside 2-substitues et procedes d'utilisation de ceux-ci pour le traitement de maladies virales - Google Patents
Derives de nucleoside 2-substitues et procedes d'utilisation de ceux-ci pour le traitement de maladies viralesInfo
- Publication number
- MA35109B1 MA35109B1 MA36408A MA36408A MA35109B1 MA 35109 B1 MA35109 B1 MA 35109B1 MA 36408 A MA36408 A MA 36408A MA 36408 A MA36408 A MA 36408A MA 35109 B1 MA35109 B1 MA 35109B1
- Authority
- MA
- Morocco
- Prior art keywords
- substituted nucleoside
- methods
- nucleoside derivatives
- treatment
- viral diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des dérivés de nucléoside 2'-substitués de formule (i) : et des sels pharmaceutiquement acceptables de ceux-ci, dans lesquels a, b, x, r1, r2 et r3 sont tels que présentement définis. La présente invention concerne en outre des compositions comprenant au moins un dérivé de nucléoside 2'-substitué, et des procédés d'utilisation des dérivés de nucléoside 2'-substitués pour traiter ou prévenir une infection par le vhc chez un patient.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161475068P | 2011-04-13 | 2011-04-13 | |
PCT/US2012/033017 WO2012142085A1 (fr) | 2011-04-13 | 2012-04-11 | Dérivés de nucléoside 2'-substitués et procédés d'utilisation de ceux-ci pour le traitement de maladies virales |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35109B1 true MA35109B1 (fr) | 2014-05-02 |
Family
ID=47009665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36408A MA35109B1 (fr) | 2011-04-13 | 2013-11-08 | Derives de nucleoside 2-substitues et procedes d'utilisation de ceux-ci pour le traitement de maladies virales |
Country Status (25)
Country | Link |
---|---|
US (1) | US9061041B2 (fr) |
EP (1) | EP2696681B1 (fr) |
JP (1) | JP2014515023A (fr) |
KR (1) | KR20130138840A (fr) |
CN (1) | CN103582420B (fr) |
AR (1) | AR086095A1 (fr) |
AU (1) | AU2012242970A1 (fr) |
BR (1) | BR112013026345A2 (fr) |
CA (1) | CA2832459A1 (fr) |
CL (1) | CL2013002939A1 (fr) |
CO (1) | CO6791618A2 (fr) |
CR (1) | CR20130531A (fr) |
DO (1) | DOP2013000238A (fr) |
EA (1) | EA201391519A1 (fr) |
EC (1) | ECSP13013019A (fr) |
IL (1) | IL228860A0 (fr) |
MA (1) | MA35109B1 (fr) |
MX (1) | MX2013011944A (fr) |
NI (1) | NI201300107A (fr) |
PE (1) | PE20140522A1 (fr) |
SG (1) | SG194485A1 (fr) |
TN (1) | TN2013000421A1 (fr) |
TW (1) | TW201247695A (fr) |
WO (1) | WO2012142085A1 (fr) |
ZA (1) | ZA201308019B (fr) |
Families Citing this family (71)
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MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
NZ547204A (en) * | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
WO2004046331A2 (fr) | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | Nucleoside a ramification en 2’ et mutation de flaviviridae |
US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
CN105061534A (zh) | 2010-09-22 | 2015-11-18 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
EP2691409B1 (fr) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Composés et compositions pharmaceutiques pour le traitement d'infections virales |
US9156872B2 (en) * | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
US9408863B2 (en) | 2011-07-13 | 2016-08-09 | Merck Sharp & Dohme Corp. | 5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases |
EP2731434A4 (fr) | 2011-07-13 | 2014-12-31 | Merck Sharp & Dohme | Dérivés de nucléosides 5'-substitués et leurs procédés d'utilisation pour le traitement de maladies virales |
WO2013033900A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques et leurs procédés d'utilisation pour le traitement de maladies virales |
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WO2013033899A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Composés benzofuranes substitués et leur procédés d'utilisation pour le traitement de maladies virales |
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US20150057246A1 (en) * | 2011-09-14 | 2015-02-26 | Michael P. Dwyer | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
TW201331221A (zh) | 2011-10-14 | 2013-08-01 | Idenix Pharmaceuticals Inc | 嘌呤核苷酸化合物類之經取代的3’,5’-環磷酸酯及用於治療病毒感染之醫藥組成物 |
WO2013084165A1 (fr) * | 2011-12-05 | 2013-06-13 | Medivir Ab | Inhibiteurs de vhc polymérase |
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US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
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- 2012-04-11 CN CN201280028104.2A patent/CN103582420B/zh not_active Expired - Fee Related
- 2012-04-13 TW TW101113340A patent/TW201247695A/zh unknown
- 2012-04-13 AR ARP120101282A patent/AR086095A1/es unknown
-
2013
- 2013-10-11 DO DO2013000238A patent/DOP2013000238A/es unknown
- 2013-10-11 CO CO13242985A patent/CO6791618A2/es not_active Application Discontinuation
- 2013-10-11 CL CL2013002939A patent/CL2013002939A1/es unknown
- 2013-10-11 NI NI201300107A patent/NI201300107A/es unknown
- 2013-10-13 IL IL228860A patent/IL228860A0/en unknown
- 2013-10-14 TN TNP2013000421A patent/TN2013000421A1/fr unknown
- 2013-10-14 CR CR20130531A patent/CR20130531A/es unknown
- 2013-10-29 ZA ZA2013/08019A patent/ZA201308019B/en unknown
- 2013-11-08 MA MA36408A patent/MA35109B1/fr unknown
- 2013-11-13 EC ECSP13013019 patent/ECSP13013019A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20130138840A (ko) | 2013-12-19 |
TW201247695A (en) | 2012-12-01 |
CN103582420A (zh) | 2014-02-12 |
IL228860A0 (en) | 2013-12-31 |
US9061041B2 (en) | 2015-06-23 |
EP2696681B1 (fr) | 2018-10-03 |
PE20140522A1 (es) | 2014-05-03 |
EP2696681A1 (fr) | 2014-02-19 |
ZA201308019B (en) | 2014-08-27 |
TN2013000421A1 (en) | 2015-03-30 |
EP2696681A4 (fr) | 2014-10-01 |
AR086095A1 (es) | 2013-11-20 |
CO6791618A2 (es) | 2013-11-14 |
CL2013002939A1 (es) | 2014-07-04 |
BR112013026345A2 (pt) | 2019-04-24 |
AU2012242970A1 (en) | 2013-10-24 |
US20140154211A1 (en) | 2014-06-05 |
DOP2013000238A (es) | 2014-01-31 |
SG194485A1 (en) | 2013-12-30 |
ECSP13013019A (es) | 2014-01-31 |
CR20130531A (es) | 2013-12-04 |
CN103582420B (zh) | 2016-10-19 |
CA2832459A1 (fr) | 2012-10-18 |
WO2012142085A1 (fr) | 2012-10-18 |
JP2014515023A (ja) | 2014-06-26 |
EA201391519A1 (ru) | 2014-03-31 |
MX2013011944A (es) | 2014-05-07 |
NI201300107A (es) | 2014-02-28 |
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