CL2013002939A1 - Compuestos derivados de nucleosidos 2´-sustituidos , inhibidores ns5a; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. - Google Patents
Compuestos derivados de nucleosidos 2´-sustituidos , inhibidores ns5a; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.Info
- Publication number
- CL2013002939A1 CL2013002939A1 CL2013002939A CL2013002939A CL2013002939A1 CL 2013002939 A1 CL2013002939 A1 CL 2013002939A1 CL 2013002939 A CL2013002939 A CL 2013002939A CL 2013002939 A CL2013002939 A CL 2013002939A CL 2013002939 A1 CL2013002939 A1 CL 2013002939A1
- Authority
- CL
- Chile
- Prior art keywords
- hepatitis
- treatment
- pharmaceutical composition
- compounds derived
- ns5a inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161475068P | 2011-04-13 | 2011-04-13 |
Publications (1)
Publication Number | Publication Date |
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CL2013002939A1 true CL2013002939A1 (es) | 2014-07-04 |
Family
ID=47009665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002939A CL2013002939A1 (es) | 2011-04-13 | 2013-10-11 | Compuestos derivados de nucleosidos 2´-sustituidos , inhibidores ns5a; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
Country Status (25)
Country | Link |
---|---|
US (1) | US9061041B2 (es) |
EP (1) | EP2696681B1 (es) |
JP (1) | JP2014515023A (es) |
KR (1) | KR20130138840A (es) |
CN (1) | CN103582420B (es) |
AR (1) | AR086095A1 (es) |
AU (1) | AU2012242970A1 (es) |
BR (1) | BR112013026345A2 (es) |
CA (1) | CA2832459A1 (es) |
CL (1) | CL2013002939A1 (es) |
CO (1) | CO6791618A2 (es) |
CR (1) | CR20130531A (es) |
DO (1) | DOP2013000238A (es) |
EA (1) | EA201391519A1 (es) |
EC (1) | ECSP13013019A (es) |
IL (1) | IL228860A0 (es) |
MA (1) | MA35109B1 (es) |
MX (1) | MX2013011944A (es) |
NI (1) | NI201300107A (es) |
PE (1) | PE20140522A1 (es) |
SG (1) | SG194485A1 (es) |
TN (1) | TN2013000421A1 (es) |
TW (1) | TW201247695A (es) |
WO (1) | WO2012142085A1 (es) |
ZA (1) | ZA201308019B (es) |
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2012
- 2012-04-11 WO PCT/US2012/033017 patent/WO2012142085A1/en active Application Filing
- 2012-04-11 BR BR112013026345-8A patent/BR112013026345A2/pt not_active IP Right Cessation
- 2012-04-11 AU AU2012242970A patent/AU2012242970A1/en not_active Abandoned
- 2012-04-11 MX MX2013011944A patent/MX2013011944A/es not_active Application Discontinuation
- 2012-04-11 PE PE2013002285A patent/PE20140522A1/es not_active Application Discontinuation
- 2012-04-11 US US14/111,687 patent/US9061041B2/en active Active
- 2012-04-11 SG SG2013076518A patent/SG194485A1/en unknown
- 2012-04-11 EP EP12771566.2A patent/EP2696681B1/en active Active
- 2012-04-11 KR KR1020137029682A patent/KR20130138840A/ko not_active Application Discontinuation
- 2012-04-11 JP JP2014505234A patent/JP2014515023A/ja active Pending
- 2012-04-11 CN CN201280028104.2A patent/CN103582420B/zh not_active Expired - Fee Related
- 2012-04-11 CA CA2832459A patent/CA2832459A1/en not_active Abandoned
- 2012-04-11 EA EA201391519A patent/EA201391519A1/ru unknown
- 2012-04-13 AR ARP120101282A patent/AR086095A1/es unknown
- 2012-04-13 TW TW101113340A patent/TW201247695A/zh unknown
-
2013
- 2013-10-11 CO CO13242985A patent/CO6791618A2/es not_active Application Discontinuation
- 2013-10-11 DO DO2013000238A patent/DOP2013000238A/es unknown
- 2013-10-11 NI NI201300107A patent/NI201300107A/es unknown
- 2013-10-11 CL CL2013002939A patent/CL2013002939A1/es unknown
- 2013-10-13 IL IL228860A patent/IL228860A0/en unknown
- 2013-10-14 TN TNP2013000421A patent/TN2013000421A1/fr unknown
- 2013-10-14 CR CR20130531A patent/CR20130531A/es unknown
- 2013-10-29 ZA ZA2013/08019A patent/ZA201308019B/en unknown
- 2013-11-08 MA MA36408A patent/MA35109B1/fr unknown
- 2013-11-13 EC ECSP13013019 patent/ECSP13013019A/es unknown
Also Published As
Publication number | Publication date |
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TN2013000421A1 (en) | 2015-03-30 |
CN103582420A (zh) | 2014-02-12 |
EP2696681A1 (en) | 2014-02-19 |
ZA201308019B (en) | 2014-08-27 |
IL228860A0 (en) | 2013-12-31 |
CR20130531A (es) | 2013-12-04 |
JP2014515023A (ja) | 2014-06-26 |
MA35109B1 (fr) | 2014-05-02 |
TW201247695A (en) | 2012-12-01 |
EP2696681A4 (en) | 2014-10-01 |
WO2012142085A1 (en) | 2012-10-18 |
NI201300107A (es) | 2014-02-28 |
AU2012242970A1 (en) | 2013-10-24 |
CO6791618A2 (es) | 2013-11-14 |
MX2013011944A (es) | 2014-05-07 |
EA201391519A1 (ru) | 2014-03-31 |
ECSP13013019A (es) | 2014-01-31 |
EP2696681B1 (en) | 2018-10-03 |
CA2832459A1 (en) | 2012-10-18 |
US9061041B2 (en) | 2015-06-23 |
US20140154211A1 (en) | 2014-06-05 |
AR086095A1 (es) | 2013-11-20 |
BR112013026345A2 (pt) | 2019-04-24 |
KR20130138840A (ko) | 2013-12-19 |
SG194485A1 (en) | 2013-12-30 |
CN103582420B (zh) | 2016-10-19 |
PE20140522A1 (es) | 2014-05-03 |
DOP2013000238A (es) | 2014-01-31 |
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