HUP0400545A2 - Uro-szelektív alfa1-adrenoceptor gátlóanyagokként használatos 1,4-diszubsztituált piperazinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Uro-szelektív alfa1-adrenoceptor gátlóanyagokként használatos 1,4-diszubsztituált piperazinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0400545A2
HUP0400545A2 HU0400545A HUP0400545A HUP0400545A2 HU P0400545 A2 HUP0400545 A2 HU P0400545A2 HU 0400545 A HU0400545 A HU 0400545A HU P0400545 A HUP0400545 A HU P0400545A HU P0400545 A2 HUP0400545 A2 HU P0400545A2
Authority
HU
Hungary
Prior art keywords
uro
compounds
pharmaceutical compositions
compositions containing
piperazine derivatives
Prior art date
Application number
HU0400545A
Other languages
English (en)
Inventor
Nitya Anand
Anita Chugh
Jang Bahadur Gupta
Laxminarayan G. Hegde
Sanjay Jain
Neelima Sinha
Original Assignee
Ranbaxy Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Limited filed Critical Ranbaxy Laboratories Limited
Publication of HUP0400545A2 publication Critical patent/HUP0400545A2/hu
Publication of HUP0400545A3 publication Critical patent/HUP0400545A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Jelen találmány (I) általános képletű új 1,4-diszubsztituált piperazinszármazékokra vonatkozik és gyógyászatilag elfogadható savas addícióssóira, amelynek kiváló uro-szelektív a1-adrenoceptor antagonistaaktivitással rendelkeznek. A jelen találmány szerinti vegyületekjelentős ígérettel bírnak a jóindulatú prosztata hyperplasia tünetekkezelésére. A találmány eljárásokra is vonatkozik az új vegyületek, avegyületeket tartalmazó gyógyászati kompozíciók készítésére, ésmódszerre a jóindulatú prosztata hyperplasia tünetek kezelésére avegyületek alkalmazásával. Az (I) általános képletben A jelentéseegyenes vagy elágazó C1-C4 alkilcsoport; R jelentése cinnamil-,benzil- vagy szubsztituált benzil-, fenilcsoport. Ó
HU0400545A 2000-11-30 2001-11-29 1,4-disubstituted piperazine derivatives useful as uro-selectives alpha1-adrenoceptor blockers, and pharmaceutical compositions containing them HUP0400545A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1097DE2000 2000-11-30
PCT/IB2001/002261 WO2002044151A1 (en) 2000-11-30 2001-11-29 1,4-disubstituted piperazine derivatives useful as uro-selective $g(a)1-adrenoceptor blockers

Publications (2)

Publication Number Publication Date
HUP0400545A2 true HUP0400545A2 (hu) 2004-07-28
HUP0400545A3 HUP0400545A3 (en) 2007-05-02

Family

ID=11097130

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400545A HUP0400545A3 (en) 2000-11-30 2001-11-29 1,4-disubstituted piperazine derivatives useful as uro-selectives alpha1-adrenoceptor blockers, and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US6914064B2 (hu)
EP (1) EP1339682A1 (hu)
JP (1) JP2004514711A (hu)
KR (1) KR20030068164A (hu)
CN (1) CN1230423C (hu)
AP (1) AP2003002810A0 (hu)
AR (1) AR035930A1 (hu)
AU (2) AU2231502A (hu)
BG (1) BG107943A (hu)
BR (1) BR0115865A (hu)
CA (1) CA2430343A1 (hu)
CZ (1) CZ20031698A3 (hu)
DO (1) DOP2001000296A (hu)
EA (1) EA006941B1 (hu)
EE (1) EE200300250A (hu)
HU (1) HUP0400545A3 (hu)
MA (1) MA26064A1 (hu)
MX (1) MXPA03004850A (hu)
NZ (1) NZ526226A (hu)
OA (1) OA12537A (hu)
PA (1) PA8534001A1 (hu)
PL (1) PL362210A1 (hu)
SK (1) SK8052003A3 (hu)
WO (1) WO2002044151A1 (hu)
ZA (1) ZA200304242B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005527578A (ja) * 2002-04-08 2005-09-15 ランバクシー ラボラトリーズ リミテッド 有用な尿選択的α１Ａアドレナリン受容体遮断薬としてのα，ω−ジカルボキシイミド誘導体
AU2003278403A1 (en) * 2003-10-15 2005-05-05 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist
WO2005092341A1 (en) * 2004-03-22 2005-10-06 Ranbaxy Laboratories Limited Combination therapy for lower urinary tract symptoms
WO2005113498A1 (en) * 2004-05-19 2005-12-01 Ranbaxy Laboratories Limited Adrenergic receptor antagonists
EP1758583A2 (en) * 2004-05-31 2007-03-07 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as adrenergic receptor antagonists
WO2006018815A1 (en) * 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Piperazine derivatives as adrenergic receptor antagonists
WO2006051374A2 (en) * 2004-11-11 2006-05-18 Ranbaxy Laboratories Limited Arylpiperazines useful as adrenergic receptor antagonists
WO2006051399A1 (en) * 2004-11-11 2006-05-18 Ranbaxy Laboratories Limited Piperazine derivatives useful as adrenergic receptor antagonists
WO2006092710A1 (en) * 2005-03-02 2006-09-08 Ranbaxy Laboratories Limited Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione
WO2006117760A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Adrenergic receptor antagonists
WO2007029156A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Isoindoledione derivatives as adrenergic receptor antagonists
WO2007039809A1 (en) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited Metabolites of 2- {3-[4-(5-fluoro-2-isopropoxy-phenyl)-piperazin-1-yl]-propyl} -5,6-dihydroxy-hexahydro-isoindole-1,3-dione
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
WO2010040274A1 (zh) 2008-10-10 2010-04-15 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
WO2010129709A1 (en) 2009-05-05 2010-11-11 Alnylam Pharmaceuticals, Inc. Lipid compositions

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Publication number Priority date Publication date Assignee Title
JPS57197265A (en) * 1981-05-29 1982-12-03 Eisai Co Ltd Carboxylic acid imide derivative, its preparation and medicament containing the same
JPS5936661A (ja) * 1982-08-26 1984-02-28 Eisai Co Ltd カルボン酸イミド誘導体およびその製造方法ならびにそれを含有する医薬
JPS5976059A (ja) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd 環状イミド誘導体及びその酸付加塩
JPS5995267A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd カルボン酸イミド誘導体およびその製造方法
AT387773B (de) * 1983-09-12 1989-03-10 Bristol Myers Co Verfahren zur herstellung von 1-heteroaryl-4-((2,5-pyrrolidindion-1-yl)aklyl) iperazin-derivaten
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
JPS60204784A (ja) 1984-03-29 1985-10-16 Eisai Co Ltd カルボン酸イミド誘導体
JP2918899B2 (ja) 1989-03-09 1999-07-12 住友製薬株式会社 環状イミド誘導体の製造方法
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
EP0748800B1 (en) * 1995-06-09 2001-05-09 F. Hoffmann-La Roche Ag Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists
WO1998037893A1 (fr) 1997-02-26 1998-09-03 Sumitomo Pharmaceuticals Co., Ltd. Antagoniste du recepteur dopaminergique d4
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Also Published As

Publication number Publication date
HUP0400545A3 (en) 2007-05-02
BG107943A (bg) 2004-08-31
AU2002222315B2 (en) 2007-06-21
NZ526226A (en) 2004-05-28
MXPA03004850A (es) 2004-01-26
EA006941B1 (ru) 2006-06-30
ZA200304242B (en) 2004-03-02
MA26064A1 (fr) 2004-04-01
BR0115865A (pt) 2003-12-23
WO2002044151A1 (en) 2002-06-06
AU2231502A (en) 2002-06-11
KR20030068164A (ko) 2003-08-19
AR035930A1 (es) 2004-07-28
CN1230423C (zh) 2005-12-07
US6914064B2 (en) 2005-07-05
CN1486300A (zh) 2004-03-31
CZ20031698A3 (cs) 2003-11-12
AP2003002810A0 (en) 2003-06-30
US20020156085A1 (en) 2002-10-24
PA8534001A1 (es) 2002-12-11
EE200300250A (et) 2003-10-15
PL362210A1 (en) 2004-10-18
OA12537A (en) 2006-06-05
EA200300620A1 (ru) 2003-12-25
JP2004514711A (ja) 2004-05-20
DOP2001000296A (es) 2003-03-15
EP1339682A1 (en) 2003-09-03
SK8052003A3 (en) 2003-12-02
CA2430343A1 (en) 2002-06-06

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Owner name: RANBAXY LABORATORIES LIMITED, IN

Free format text: FORMER OWNER(S): RANBAXY LABORATORIES LIMITED, IN

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished