ES2172436A1 - Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. - Google Patents
Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.Info
- Publication number
- ES2172436A1 ES2172436A1 ES200002615A ES200002615A ES2172436A1 ES 2172436 A1 ES2172436 A1 ES 2172436A1 ES 200002615 A ES200002615 A ES 200002615A ES 200002615 A ES200002615 A ES 200002615A ES 2172436 A1 ES2172436 A1 ES 2172436A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- antihistaminic
- groups
- antiallergic agents
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Derivados de indolilpiperidina como agentes antihistamínicos y antialérgicos de fórmula (I): **Figura01** en donde A{sup,1} y A{sup,2} son grupos orgánicos insaturados: W{sup,1} es un grupo cíclico insaturado; W{sup,2} es un grupo monocíclico o bicíclico de 3 a 10 miembros; R{sup,1} es H o Hal o un grupo alquilo, alcoxi o metilamino; y R{sup,2} es -COOH o un grupo tetrazolilo, y sus correspondientes sales farmacéuticamente aceptables; procedimientos para su preparación; composiciones farmacéuticas que los contengan; y su uso médico como agentes antihistamínicos y antialérgicos.
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002615A ES2172436B1 (es) | 2000-10-31 | 2000-10-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
US10/415,693 US7189741B2 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
JP2002539348A JP4184785B2 (ja) | 2000-10-31 | 2001-10-26 | 抗ヒスタミン薬及び抗アレルギー薬としてのインドリルピペリジン誘導体 |
DE60118434T DE60118434T2 (de) | 2000-10-31 | 2001-10-26 | Indolylpiperidinderivate als antihistaminische und antiallergische mittel |
CA002427589A CA2427589A1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
ES01992709T ES2259052T3 (es) | 2000-10-31 | 2001-10-26 | Derivados de indolipiperidina como agentes antihistaminicos y antialergicos. |
EP01992709A EP1330453B1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
PCT/EP2001/012450 WO2002036589A1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
DK01992709T DK1330453T3 (da) | 2000-10-31 | 2001-10-26 | Indolylpiperidinderivater som antihistamin- og anti-allergimidler |
SI200130521T SI1330453T1 (sl) | 2000-10-31 | 2001-10-26 | Derivati indolilpiperidina kot antihistaminicna in antialergijska sredstva |
PT01992709T PT1330453E (pt) | 2000-10-31 | 2001-10-26 | Derivados de indolilpiperidina como agentes anti-histaminicos e antialergicos |
AT01992709T ATE321761T1 (de) | 2000-10-31 | 2001-10-26 | Indolylpiperidinderivate als antihistaminische und antiallergische mittel |
AU2002223655A AU2002223655A1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
PE2001001079A PE20020543A1 (es) | 2000-10-31 | 2001-10-30 | Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos |
MYPI20015021A MY155914A (en) | 2000-10-31 | 2001-10-30 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
ARP010105068A AR031168A1 (es) | 2000-10-31 | 2001-10-30 | Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos |
UY27001A UY27001A1 (es) | 2000-10-31 | 2001-10-31 | Derivados de la indolilpiperidina como agentes antihistamínicos y antialérgicos |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002615A ES2172436B1 (es) | 2000-10-31 | 2000-10-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2172436A1 true ES2172436A1 (es) | 2002-09-16 |
ES2172436B1 ES2172436B1 (es) | 2004-01-16 |
Family
ID=8495472
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002615A Expired - Fee Related ES2172436B1 (es) | 2000-10-31 | 2000-10-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
ES01992709T Expired - Lifetime ES2259052T3 (es) | 2000-10-31 | 2001-10-26 | Derivados de indolipiperidina como agentes antihistaminicos y antialergicos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01992709T Expired - Lifetime ES2259052T3 (es) | 2000-10-31 | 2001-10-26 | Derivados de indolipiperidina como agentes antihistaminicos y antialergicos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7189741B2 (es) |
EP (1) | EP1330453B1 (es) |
JP (1) | JP4184785B2 (es) |
AR (1) | AR031168A1 (es) |
AT (1) | ATE321761T1 (es) |
AU (1) | AU2002223655A1 (es) |
CA (1) | CA2427589A1 (es) |
DE (1) | DE60118434T2 (es) |
DK (1) | DK1330453T3 (es) |
ES (2) | ES2172436B1 (es) |
MY (1) | MY155914A (es) |
PE (1) | PE20020543A1 (es) |
PT (1) | PT1330453E (es) |
SI (1) | SI1330453T1 (es) |
UY (1) | UY27001A1 (es) |
WO (1) | WO2002036589A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
ES2201907B1 (es) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos. |
NZ537200A (en) | 2002-06-24 | 2007-09-28 | Schering Corp | Indole piperidine derivatives useful as histamine H3 antagonists |
WO2004047769A2 (en) * | 2002-11-26 | 2004-06-10 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antibacterials |
JP2009515833A (ja) * | 2005-10-24 | 2009-04-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 3−ピペリジン−4−イル−インドールorl−1受容体モジュレーター |
WO2008049874A1 (en) * | 2006-10-27 | 2008-05-02 | Boehringer Ingelheim International Gmbh | Piperidyl-propane-thiol ccr3 modulators |
JP5550352B2 (ja) * | 2007-03-15 | 2014-07-16 | ノバルティス アーゲー | 有機化合物およびその使用 |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0224919A2 (en) * | 1985-12-05 | 1987-06-10 | Fujisawa Pharmaceutical Co., Ltd. | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
WO1995001350A1 (en) * | 1993-06-29 | 1995-01-12 | Sumitomo Metal Industries, Ltd. | Tetrazole derivatives having antihistaminic and antiallergic activity |
US5650416A (en) * | 1992-02-13 | 1997-07-22 | Merrell Pharmaceuticals Inc. | Piperidinyl thiacyclic derivatives |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK471479A (da) | 1978-12-13 | 1980-06-14 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
US4843068A (en) | 1985-12-27 | 1989-06-27 | Nihon Nohyaku Co., Ltd. | Pyrazole oxime derivatives and compositions |
DK733788A (da) | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
IT1271417B (it) | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono. |
DE19500689A1 (de) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
DE19707628A1 (de) | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
ES2165274B1 (es) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
AR028685A1 (es) | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
-
2000
- 2000-10-31 ES ES200002615A patent/ES2172436B1/es not_active Expired - Fee Related
-
2001
- 2001-10-26 CA CA002427589A patent/CA2427589A1/en not_active Abandoned
- 2001-10-26 JP JP2002539348A patent/JP4184785B2/ja not_active Expired - Fee Related
- 2001-10-26 SI SI200130521T patent/SI1330453T1/sl unknown
- 2001-10-26 DE DE60118434T patent/DE60118434T2/de not_active Expired - Lifetime
- 2001-10-26 WO PCT/EP2001/012450 patent/WO2002036589A1/en active IP Right Grant
- 2001-10-26 PT PT01992709T patent/PT1330453E/pt unknown
- 2001-10-26 AU AU2002223655A patent/AU2002223655A1/en not_active Abandoned
- 2001-10-26 EP EP01992709A patent/EP1330453B1/en not_active Expired - Lifetime
- 2001-10-26 AT AT01992709T patent/ATE321761T1/de not_active IP Right Cessation
- 2001-10-26 ES ES01992709T patent/ES2259052T3/es not_active Expired - Lifetime
- 2001-10-26 DK DK01992709T patent/DK1330453T3/da active
- 2001-10-26 US US10/415,693 patent/US7189741B2/en not_active Expired - Fee Related
- 2001-10-30 AR ARP010105068A patent/AR031168A1/es not_active Application Discontinuation
- 2001-10-30 MY MYPI20015021A patent/MY155914A/en unknown
- 2001-10-30 PE PE2001001079A patent/PE20020543A1/es not_active Application Discontinuation
- 2001-10-31 UY UY27001A patent/UY27001A1/es unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0224919A2 (en) * | 1985-12-05 | 1987-06-10 | Fujisawa Pharmaceutical Co., Ltd. | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
US5650416A (en) * | 1992-02-13 | 1997-07-22 | Merrell Pharmaceuticals Inc. | Piperidinyl thiacyclic derivatives |
WO1995001350A1 (en) * | 1993-06-29 | 1995-01-12 | Sumitomo Metal Industries, Ltd. | Tetrazole derivatives having antihistaminic and antiallergic activity |
Also Published As
Publication number | Publication date |
---|---|
DK1330453T3 (da) | 2006-08-07 |
ES2259052T3 (es) | 2006-09-16 |
WO2002036589A1 (en) | 2002-05-10 |
DE60118434T2 (de) | 2006-12-14 |
EP1330453B1 (en) | 2006-03-29 |
CA2427589A1 (en) | 2002-05-10 |
PT1330453E (pt) | 2006-07-31 |
JP2004513127A (ja) | 2004-04-30 |
UY27001A1 (es) | 2001-12-28 |
MY155914A (en) | 2015-12-15 |
AU2002223655A1 (en) | 2002-05-15 |
AR031168A1 (es) | 2003-09-10 |
ES2172436B1 (es) | 2004-01-16 |
US20040116471A1 (en) | 2004-06-17 |
SI1330453T1 (sl) | 2006-08-31 |
ATE321761T1 (de) | 2006-04-15 |
EP1330453A1 (en) | 2003-07-30 |
JP4184785B2 (ja) | 2008-11-19 |
PE20020543A1 (es) | 2002-07-17 |
US7189741B2 (en) | 2007-03-13 |
DE60118434D1 (de) | 2006-05-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200200938A1 (ru) | Фармацевтические композиции, содержащие производные азетидина, новые производные азетидина и их получение | |
DK0889877T3 (da) | Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer | |
DK0889876T3 (da) | Meta-substituerede phenylensulfonamidderivater | |
BR0111263A (pt) | Derivados de 2-aminocarbonil-9h-purina | |
TR200101155T2 (tr) | 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III | |
PL315636A1 (en) | Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives | |
AR020032A1 (es) | Derivados de 1,3 -metil eritromicina. | |
DK0928788T3 (da) | Imidazolidin-4-on-derivater, der er nyttige som anticancer-midler | |
EA200600811A1 (ru) | НОВЫЕ ПРОИЗВОДНЫЕ ТЕТРАГИДРОСПИРО {ПИПЕРИДИН-2,7'-ПИРРОЛО [3,2-b]ПИРИДИНА} И НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С 5-HT-РЕЦЕПТОРОМ | |
WO2002051819A3 (en) | Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them | |
ES2165274A1 (es) | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. | |
YU53100A (sh) | Derivati 2-ariletil-(piperidin-4-ilmetil)amina kao antagonisti muskarinskih receptora | |
EA200200774A1 (ru) | Новые соединения, обладающие гиполипидемической, гипохолестеринемической активностью, способ их получения и содержащие их композиции | |
MXPA03000161A (es) | Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen. | |
EA200300071A1 (ru) | Терапевтический препарат для лечения невроза страха (тревоги) или депрессии и производные пиперазина | |
PT992509E (pt) | Novos derivados macrolidos | |
ES2172436A1 (es) | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. | |
EA200301203A1 (ru) | Новые соединения и композиции как ингибиторы катепсина | |
EA200100916A1 (ru) | Лекарственное средство, содержащее производное сульфопиранозилацилглицерина | |
HUP0400545A2 (hu) | Uro-szelektív alfa1-adrenoceptor gátlóanyagokként használatos 1,4-diszubsztituált piperazinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
NO983444D0 (no) | Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer | |
HU0004701D0 (es) | ||
DE60130628D1 (de) | Aminophenoxyacetamid derivate und diese enthaltende pharmazeutische zusammensetzungen | |
GR900300046T1 (en) | Oxabicycloheptane derivatives, pharmaceutical composition and use | |
NZ225528A (en) | Benzimidazoles substituted in the 2 position by n(4-n-guanidyl) piperidinyl radicals; preparations thereof; pharmaceutical compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20020916 Kind code of ref document: A1 Effective date: 20020916 |
|
FG2A | Definitive protection |
Ref document number: 2172436B1 Country of ref document: ES |
|
FD1A | Patent lapsed |
Effective date: 20100315 |