ES2172436A1 - Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. - Google Patents

Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Info

Publication number
ES2172436A1
ES2172436A1 ES200002615A ES200002615A ES2172436A1 ES 2172436 A1 ES2172436 A1 ES 2172436A1 ES 200002615 A ES200002615 A ES 200002615A ES 200002615 A ES200002615 A ES 200002615A ES 2172436 A1 ES2172436 A1 ES 2172436A1
Authority
ES
Spain
Prior art keywords
group
antihistaminic
groups
antiallergic agents
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200002615A
Other languages
English (en)
Other versions
ES2172436B1 (es
Inventor
Pou Silvia Fonquerna
Santacana Lluis Pages
Duran Carles Puig
Pueyo Lidia Soca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200002615A priority Critical patent/ES2172436B1/es
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to DE60118434T priority patent/DE60118434T2/de
Priority to PCT/EP2001/012450 priority patent/WO2002036589A1/en
Priority to SI200130521T priority patent/SI1330453T1/sl
Priority to US10/415,693 priority patent/US7189741B2/en
Priority to EP01992709A priority patent/EP1330453B1/en
Priority to CA002427589A priority patent/CA2427589A1/en
Priority to DK01992709T priority patent/DK1330453T3/da
Priority to AT01992709T priority patent/ATE321761T1/de
Priority to AU2002223655A priority patent/AU2002223655A1/en
Priority to JP2002539348A priority patent/JP4184785B2/ja
Priority to ES01992709T priority patent/ES2259052T3/es
Priority to PT01992709T priority patent/PT1330453E/pt
Priority to ARP010105068A priority patent/AR031168A1/es
Priority to MYPI20015021A priority patent/MY155914A/en
Priority to PE2001001079A priority patent/PE20020543A1/es
Priority to UY27001A priority patent/UY27001A1/es
Publication of ES2172436A1 publication Critical patent/ES2172436A1/es
Application granted granted Critical
Publication of ES2172436B1 publication Critical patent/ES2172436B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Derivados de indolilpiperidina como agentes antihistamínicos y antialérgicos de fórmula (I): **Figura01** en donde A{sup,1} y A{sup,2} son grupos orgánicos insaturados: W{sup,1} es un grupo cíclico insaturado; W{sup,2} es un grupo monocíclico o bicíclico de 3 a 10 miembros; R{sup,1} es H o Hal o un grupo alquilo, alcoxi o metilamino; y R{sup,2} es -COOH o un grupo tetrazolilo, y sus correspondientes sales farmacéuticamente aceptables; procedimientos para su preparación; composiciones farmacéuticas que los contengan; y su uso médico como agentes antihistamínicos y antialérgicos.
ES200002615A 2000-10-31 2000-10-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. Expired - Fee Related ES2172436B1 (es)

Priority Applications (17)

Application Number Priority Date Filing Date Title
ES200002615A ES2172436B1 (es) 2000-10-31 2000-10-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
PT01992709T PT1330453E (pt) 2000-10-31 2001-10-26 Derivados de indolilpiperidina como agentes anti-histaminicos e antialergicos
SI200130521T SI1330453T1 (sl) 2000-10-31 2001-10-26 Derivati indolilpiperidina kot antihistaminicna in antialergijska sredstva
US10/415,693 US7189741B2 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
EP01992709A EP1330453B1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
CA002427589A CA2427589A1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
DK01992709T DK1330453T3 (da) 2000-10-31 2001-10-26 Indolylpiperidinderivater som antihistamin- og anti-allergimidler
AT01992709T ATE321761T1 (de) 2000-10-31 2001-10-26 Indolylpiperidinderivate als antihistaminische und antiallergische mittel
DE60118434T DE60118434T2 (de) 2000-10-31 2001-10-26 Indolylpiperidinderivate als antihistaminische und antiallergische mittel
JP2002539348A JP4184785B2 (ja) 2000-10-31 2001-10-26 抗ヒスタミン薬及び抗アレルギー薬としてのインドリルピペリジン誘導体
ES01992709T ES2259052T3 (es) 2000-10-31 2001-10-26 Derivados de indolipiperidina como agentes antihistaminicos y antialergicos.
PCT/EP2001/012450 WO2002036589A1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
AU2002223655A AU2002223655A1 (en) 2000-10-31 2001-10-26 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
ARP010105068A AR031168A1 (es) 2000-10-31 2001-10-30 Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos
MYPI20015021A MY155914A (en) 2000-10-31 2001-10-30 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
PE2001001079A PE20020543A1 (es) 2000-10-31 2001-10-30 Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos
UY27001A UY27001A1 (es) 2000-10-31 2001-10-31 Derivados de la indolilpiperidina como agentes antihistamínicos y antialérgicos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002615A ES2172436B1 (es) 2000-10-31 2000-10-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Publications (2)

Publication Number Publication Date
ES2172436A1 true ES2172436A1 (es) 2002-09-16
ES2172436B1 ES2172436B1 (es) 2004-01-16

Family

ID=8495472

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200002615A Expired - Fee Related ES2172436B1 (es) 2000-10-31 2000-10-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
ES01992709T Expired - Lifetime ES2259052T3 (es) 2000-10-31 2001-10-26 Derivados de indolipiperidina como agentes antihistaminicos y antialergicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01992709T Expired - Lifetime ES2259052T3 (es) 2000-10-31 2001-10-26 Derivados de indolipiperidina como agentes antihistaminicos y antialergicos.

Country Status (16)

Country Link
US (1) US7189741B2 (es)
EP (1) EP1330453B1 (es)
JP (1) JP4184785B2 (es)
AR (1) AR031168A1 (es)
AT (1) ATE321761T1 (es)
AU (1) AU2002223655A1 (es)
CA (1) CA2427589A1 (es)
DE (1) DE60118434T2 (es)
DK (1) DK1330453T3 (es)
ES (2) ES2172436B1 (es)
MY (1) MY155914A (es)
PE (1) PE20020543A1 (es)
PT (1) PT1330453E (es)
SI (1) SI1330453T1 (es)
UY (1) UY27001A1 (es)
WO (1) WO2002036589A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2201899B1 (es) 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES2201907B1 (es) * 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
AU2003243709B2 (en) * 2002-06-24 2007-01-18 Schering Corporation Indole derivatives useful as histamine H3 antagonists
WO2004047769A2 (en) * 2002-11-26 2004-06-10 Isis Pharmaceuticals, Inc. Benzimidazoles and analogs thereof as antibacterials
AU2006306497A1 (en) * 2005-10-24 2007-05-03 Janssen Pharmaceutica, N.V. 3-piperidin-4-yl-indole ORL-1 receptor modulators
WO2008049874A1 (en) * 2006-10-27 2008-05-02 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol ccr3 modulators
PE20090188A1 (es) * 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0224919A2 (en) * 1985-12-05 1987-06-10 Fujisawa Pharmaceutical Co., Ltd. New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
WO1995001350A1 (en) * 1993-06-29 1995-01-12 Sumitomo Metal Industries, Ltd. Tetrazole derivatives having antihistaminic and antiallergic activity
US5650416A (en) * 1992-02-13 1997-07-22 Merrell Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK471479A (da) 1978-12-13 1980-06-14 Pfizer Fremgangsmaade til fremstilling af imidazolderivater og salte deraf
US4843068A (en) 1985-12-27 1989-06-27 Nihon Nohyaku Co., Ltd. Pyrazole oxime derivatives and compositions
DK733788A (da) 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
IT1271417B (it) 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
DE19500689A1 (de) 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
DE19707628A1 (de) 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
AR013669A1 (es) 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
ES2165274B1 (es) * 1999-06-04 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AR028685A1 (es) 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0224919A2 (en) * 1985-12-05 1987-06-10 Fujisawa Pharmaceutical Co., Ltd. New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
US5650416A (en) * 1992-02-13 1997-07-22 Merrell Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
WO1995001350A1 (en) * 1993-06-29 1995-01-12 Sumitomo Metal Industries, Ltd. Tetrazole derivatives having antihistaminic and antiallergic activity

Also Published As

Publication number Publication date
JP2004513127A (ja) 2004-04-30
ES2172436B1 (es) 2004-01-16
PE20020543A1 (es) 2002-07-17
ES2259052T3 (es) 2006-09-16
UY27001A1 (es) 2001-12-28
MY155914A (en) 2015-12-15
ATE321761T1 (de) 2006-04-15
SI1330453T1 (sl) 2006-08-31
AU2002223655A1 (en) 2002-05-15
EP1330453A1 (en) 2003-07-30
US7189741B2 (en) 2007-03-13
EP1330453B1 (en) 2006-03-29
JP4184785B2 (ja) 2008-11-19
DK1330453T3 (da) 2006-08-07
PT1330453E (pt) 2006-07-31
CA2427589A1 (en) 2002-05-10
DE60118434T2 (de) 2006-12-14
WO2002036589A1 (en) 2002-05-10
DE60118434D1 (de) 2006-05-18
US20040116471A1 (en) 2004-06-17
AR031168A1 (es) 2003-09-10

Similar Documents

Publication Publication Date Title
EA200200938A1 (ru) Фармацевтические композиции, содержащие производные азетидина, новые производные азетидина и их получение
DK0889877T3 (da) Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
DK0889876T3 (da) Meta-substituerede phenylensulfonamidderivater
BR0111263A (pt) Derivados de 2-aminocarbonil-9h-purina
TR200101155T2 (tr) 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
PL315636A1 (en) Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives
AR020032A1 (es) Derivados de 1,3 -metil eritromicina.
DK0928788T3 (da) Imidazolidin-4-on-derivater, der er nyttige som anticancer-midler
EA200600811A1 (ru) НОВЫЕ ПРОИЗВОДНЫЕ ТЕТРАГИДРОСПИРО {ПИПЕРИДИН-2,7'-ПИРРОЛО [3,2-b]ПИРИДИНА} И НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С 5-HT-РЕЦЕПТОРОМ
WO2002051819A3 (en) Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
ES2165274A1 (es) Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU4205000A (en) Xanthine derivatives and analogs as cell signaling inhibitors
YU53100A (sh) Derivati 2-ariletil-(piperidin-4-ilmetil)amina kao antagonisti muskarinskih receptora
MXPA03000161A (es) Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen.
EA200300071A1 (ru) Терапевтический препарат для лечения невроза страха (тревоги) или депрессии и производные пиперазина
ES2172436A1 (es) Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
EA200301203A1 (ru) Новые соединения и композиции как ингибиторы катепсина
EA200100916A1 (ru) Лекарственное средство, содержащее производное сульфопиранозилацилглицерина
HUP0400545A2 (hu) Uro-szelektív alfa1-adrenoceptor gátlóanyagokként használatos 1,4-diszubsztituált piperazinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
NO983444D0 (no) Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer
ES2172376A1 (es) Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
HU0004701D0 (es)
DE60130628D1 (de) Aminophenoxyacetamid derivate und diese enthaltende pharmazeutische zusammensetzungen
GR900300046T1 (en) Oxabicycloheptane derivatives, pharmaceutical composition and use
NZ225528A (en) Benzimidazoles substituted in the 2 position by n(4-n-guanidyl) piperidinyl radicals; preparations thereof; pharmaceutical compositions

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20020916

Kind code of ref document: A1

Effective date: 20020916

FG2A Definitive protection

Ref document number: 2172436B1

Country of ref document: ES

FD1A Patent lapsed

Effective date: 20100315