MXPA03000161A - Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen. - Google Patents

Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen.

Info

Publication number
MXPA03000161A
MXPA03000161A MXPA03000161A MXPA03000161A MXPA03000161A MX PA03000161 A MXPA03000161 A MX PA03000161A MX PA03000161 A MXPA03000161 A MX PA03000161A MX PA03000161 A MXPA03000161 A MX PA03000161A MX PA03000161 A MXPA03000161 A MX PA03000161A
Authority
MX
Mexico
Prior art keywords
compositions containing
preparation
pharmaceutical compositions
novel compounds
antiinflammatory activity
Prior art date
Application number
MXPA03000161A
Other languages
English (en)
Inventor
Rajagopalan Ramanujam
Original Assignee
Reddy Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddy Research Foundation filed Critical Reddy Research Foundation
Publication of MXPA03000161A publication Critical patent/MXPA03000161A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

La presente invencion se relaciona a compuestos heterociclicos novedosos de la formula general (I), sus derivados, sus analogos, sus formas tautomericas, sus estereoisomeros, sus regioisomeros, sus polimorfos, sus sales aceptables farmaceuticamente, sus solvatos aceptables farmaceuticamente y composiciones aceptables farmaceuticamente que los contienen.
MXPA03000161A 2000-05-22 2001-05-21 Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen. MXPA03000161A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN388MA2000 2000-05-22
IN436MA2000 2000-06-08
PCT/IB2001/000883 WO2001090097A2 (en) 2000-05-22 2001-05-21 Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MXPA03000161A true MXPA03000161A (es) 2004-02-26

Family

ID=26324893

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000161A MXPA03000161A (es) 2000-05-22 2001-05-21 Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen.

Country Status (6)

Country Link
US (1) US6686390B2 (es)
CN (1) CN1443180A (es)
AU (1) AU2001258677A1 (es)
CA (1) CA2412651A1 (es)
MX (1) MXPA03000161A (es)
WO (1) WO2001090097A2 (es)

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DE19818732A1 (de) * 1998-04-27 1999-10-28 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
US6900242B2 (en) * 2001-06-13 2005-05-31 Magnachem International Laboratories, Inc. Lactone formulations and method of use
MXPA05004794A (es) * 2002-11-05 2005-08-19 Magnachem Int Lab Inc Formulaciones de lactonas y metodos de uso.
ES2213485B1 (es) * 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
ES2214129B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 3-fenilfuran-2-onas.
ES2214130B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 2-3'-bipiridinas.
WO2005102315A1 (en) * 2004-04-23 2005-11-03 Magnachem International Laboratories, Inc. Synthetic lactone formulations for pain control
EP1916240A1 (en) * 2006-10-25 2008-04-30 Syngeta Participations AG Pyridazine derivatives
CA2741526A1 (en) * 2008-10-24 2010-04-29 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with rad9
US8921585B2 (en) 2010-08-18 2014-12-30 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
US9630938B2 (en) 2010-08-18 2017-04-25 Delmar Pharmaceuticals, Inc. Method of synthesis of substituted hexitols such as dianhydrogalactitol
US9085544B2 (en) 2010-08-18 2015-07-21 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
BR112013004481B1 (pt) * 2010-08-18 2021-12-21 Del Mar Pharmaceuticals Método para a síntese de hexitóis substituídos tal como dianidrogalactitol
JP2012087113A (ja) * 2010-09-22 2012-05-10 Daicel Corp フェニル酢酸化合物
PL3639828T3 (pl) 2013-12-24 2022-05-02 Virginia Commonwealth University Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby
EP3487494A1 (en) 2016-07-21 2019-05-29 Unilever PLC Lactams for the treatment of respiratory tract infections
CN117224534A (zh) 2016-07-21 2023-12-15 联合利华知识产权控股有限公司 用于治疗皮肤损伤的内酰胺
CN109475525A (zh) 2016-07-21 2019-03-15 荷兰联合利华有限公司 4-(4-氯苯基)-5-亚甲基-吡咯-2-酮和5-亚甲基-4-(对甲苯基)吡咯-2-酮用于治疗革兰氏阴性细菌感染
CN107056733B (zh) * 2017-03-24 2019-09-03 中国药科大学 具有抗癌活性的3－o－（对甲磺酸酯苯甲基）抗坏血酸及制备方法
US11191752B2 (en) 2017-04-28 2021-12-07 Case Western Reserve University Compounds and methods of treating retinal degeneration
CN110526844B (zh) * 2018-05-25 2021-11-12 江苏中旗科技股份有限公司 一种苯唑草酮中间体2,3-二甲基苯甲硫醚的合成方法
CN115925597A (zh) * 2022-12-20 2023-04-07 黄冈鲁班药业股份有限公司 双(4-磺酸基苯基)二硫化物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE895151C (de) * 1951-07-29 1953-11-02 Robert Dr Pfleger Verfahren zur Herstellung von Chlormethylsulfiden
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
WO1998041516A1 (en) * 1997-03-14 1998-09-24 Merck Frosst Canada & Co. (methylsulfonyl)phenyl-2-(5h)-furanones with oxygen link as cox-2 inhibitors
GB9615867D0 (en) * 1996-07-03 1996-09-11 Merck & Co Inc Process of preparing phenyl heterocycles useful as cox-2 inhibitors
WO1999023087A1 (en) * 1997-10-30 1999-05-14 Merck Frosst Canada & Co. Diaryl-5-alkyl-5-methyl-2(5h)-furanones as selective cyclooxygenase-2 inhibitors
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
DE60007267T2 (de) * 1999-04-14 2004-09-16 Pacific Corp. 4,5-diaryl-3(2h)-furanon derivate als cyclooxygenase-2 inhibitoren

Also Published As

Publication number Publication date
US20020032230A1 (en) 2002-03-14
CA2412651A1 (en) 2001-11-29
AU2001258677A1 (en) 2001-12-03
WO2001090097A2 (en) 2001-11-29
CN1443180A (zh) 2003-09-17
US6686390B2 (en) 2004-02-03
WO2001090097A3 (en) 2002-04-04

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