ES2165274A1 - Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. - Google Patents

Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Info

Publication number
ES2165274A1
ES2165274A1 ES009901232A ES9901232A ES2165274A1 ES 2165274 A1 ES2165274 A1 ES 2165274A1 ES 009901232 A ES009901232 A ES 009901232A ES 9901232 A ES9901232 A ES 9901232A ES 2165274 A1 ES2165274 A1 ES 2165274A1
Authority
ES
Spain
Prior art keywords
group
antihistaminic
antiallergic agents
alkylene
indolylpiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009901232A
Other languages
English (en)
Other versions
ES2165274B1 (es
Inventor
Santacana Lluis Pages
Pou Silvia Fonquerna
Duran Carles Puig
Forner Dolors Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009901232A priority Critical patent/ES2165274B1/es
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to CA002375985A priority patent/CA2375985A1/en
Priority to BR0011340-9A priority patent/BR0011340A/pt
Priority to EEP200100653A priority patent/EE04717B1/xx
Priority to EP00940296A priority patent/EP1183251B1/en
Priority to UA2001118222A priority patent/UA72517C2/uk
Priority to PL353164A priority patent/PL196774B1/pl
Priority to ES00940296T priority patent/ES2211559T3/es
Priority to PE2000000524A priority patent/PE20010208A1/es
Priority to RU2002100073/04A priority patent/RU2246493C2/ru
Priority to IL14662900A priority patent/IL146629A0/xx
Priority to JP2001502413A priority patent/JP2003501424A/ja
Priority to TR2001/03490T priority patent/TR200103490T2/xx
Priority to DE2000608239 priority patent/DE60008239T2/de
Priority to SI200030323T priority patent/SI1183251T1/xx
Priority to MXPA01012425A priority patent/MXPA01012425A/es
Priority to PCT/EP2000/005010 priority patent/WO2000075130A1/en
Priority to CNB008112819A priority patent/CN1191246C/zh
Priority to MYPI20002439A priority patent/MY127033A/en
Priority to CZ20014334A priority patent/CZ20014334A3/cs
Priority to AU55276/00A priority patent/AU773164B2/en
Priority to KR1020017015570A priority patent/KR100683454B1/ko
Priority to SK1704-2001A priority patent/SK17042001A3/sk
Priority to DK00940296T priority patent/DK1183251T3/da
Priority to AT00940296T priority patent/ATE259362T1/de
Priority to HU0203320A priority patent/HUP0203320A3/hu
Priority to NZ515649A priority patent/NZ515649A/en
Priority to PT00940296T priority patent/PT1183251E/pt
Priority to CO00041546A priority patent/CO5180556A1/es
Priority to ARP000102755A priority patent/AR029640A1/es
Priority to TW089110816A priority patent/TWI226889B/zh
Priority to ZA200109676A priority patent/ZA200109676B/en
Priority to BG106168A priority patent/BG106168A/bg
Priority to NO20015897A priority patent/NO20015897L/no
Priority to US10/006,416 priority patent/US6683096B2/en
Publication of ES2165274A1 publication Critical patent/ES2165274A1/es
Priority to HK02102119.0A priority patent/HK1040990A1/zh
Application granted granted Critical
Publication of ES2165274B1 publication Critical patent/ES2165274B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevos derivados de indolilpiperidina como agentes antihistamínicos y antialérgicos de fórmula (1) **FORMULA**en donde A{sup,1} representa un grupo alquileno, alquilenoxi, alquilentio, alquilenamino, alcanoilo o hidroxialquileno; A{sup,2} representa un enlace sencillo, un grupo alquileno o alquenileno; W representa un enlace sencillo, o un grupo fenileno o furanileno opcionalmente sustituido por uno o más átomos de halógeno, o grupos alcoxi o alquilo; R{sup,1} representa un átomo de hidrógeno o un grupo alquilo, alcoxialquilo, alcoxi-alcoxialquilo o fenilalquilo donde el anillo fenilo está opcionalmente sustituido por uno o más átomos de halógeno o grupos alquilo o alcoxi; R{sup,2} representa un átomo de hidrógeno o halógeno, o un grupo alquilo, alcoxi, amino, aminoalquilo, tioalquilo o alcanoilo; y R{sup,3} representa un grupo carboxilo o un grupo tetrazol;
ES009901232A 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. Expired - Fee Related ES2165274B1 (es)

Priority Applications (36)

Application Number Priority Date Filing Date Title
ES009901232A ES2165274B1 (es) 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU55276/00A AU773164B2 (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
EEP200100653A EE04717B1 (et) 1999-06-04 2000-05-31 Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine
EP00940296A EP1183251B1 (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
UA2001118222A UA72517C2 (uk) 1999-06-04 2000-05-31 Похідні індолілпіперидину як антигістамінні та антиалергенні агенти
PL353164A PL196774B1 (pl) 1999-06-04 2000-05-31 Pochodne indolilopiperydyny jako środki przeciwhistaminowe i przeciwalergiczne
CZ20014334A CZ20014334A3 (cs) 1999-06-04 2000-05-31 Derivát indolylpiperidinu jako antihistaminické a antialergické činidlo
PE2000000524A PE20010208A1 (es) 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos
RU2002100073/04A RU2246493C2 (ru) 1999-06-04 2000-05-31 Производные индолилпиперидина в качестве антигистаминных и противоаллергических средств
IL14662900A IL146629A0 (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
JP2001502413A JP2003501424A (ja) 1999-06-04 2000-05-31 抗ヒスタミンおよび抗アレルギー剤としてのインドリルピペリジン誘導体
TR2001/03490T TR200103490T2 (tr) 1999-06-04 2000-05-31 Antihistaminik ve antialerjik maddeler olarak indolilpiperidin türevleri
DE2000608239 DE60008239T2 (de) 1999-06-04 2000-05-31 Indolylpiperidinderivate als antihistaminische und antiallergische mittel
BR0011340-9A BR0011340A (pt) 1999-06-04 2000-05-31 Composto, processo para preparar o composto, composição, uso de um composto, e, método de tratar doenças alérgicas incluindo a asma brÈnquica, rinite, conjuntivite, dematose e urticária
MXPA01012425A MXPA01012425A (es) 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
PCT/EP2000/005010 WO2000075130A1 (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
CNB008112819A CN1191246C (zh) 1999-06-04 2000-05-31 作为抗组胺剂和抗过敏剂的吲哚基哌啶衍生物
KR1020017015570A KR100683454B1 (ko) 1999-06-04 2000-05-31 항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체
CA002375985A CA2375985A1 (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
ES00940296T ES2211559T3 (es) 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes anhistaminicos y antialergicos.
MYPI20002439A MY127033A (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents.
SK1704-2001A SK17042001A3 (sk) 1999-06-04 2000-05-31 Derivát indolylpiperidínu ako antihistaminické a antialergické činidlo
DK00940296T DK1183251T3 (da) 1999-06-04 2000-05-31 Indolylpiperidinderivater som antihistamin- og antiallergimidler
AT00940296T ATE259362T1 (de) 1999-06-04 2000-05-31 Indolylpiperidinderivate als antihistaminische und antiallergische mittel
HU0203320A HUP0203320A3 (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives and their use as antihistaminic and antiallergic agents, process for their preparation, pharmaceutical compositions containing them
NZ515649A NZ515649A (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
PT00940296T PT1183251E (pt) 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes anti-histaminicos e anti-alergicos
SI200030323T SI1183251T1 (en) 1999-06-04 2000-05-31 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
CO00041546A CO5180556A1 (es) 1999-06-04 2000-06-02 Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos
ARP000102755A AR029640A1 (es) 1999-06-04 2000-06-02 Derivados de indolilpiperidinas que poseen actividad antihistaminica y antialergica, procesos para preparar dichos derivados y compuestos intermediarios utilizables en dicho proceso, composiciones formuladas con dichos derivados y uso de los derivados mencionados para el tratamiento del cuerpo human
TW089110816A TWI226889B (en) 1999-06-04 2000-06-02 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
ZA200109676A ZA200109676B (en) 1999-06-04 2001-11-23 Indolylpiperidine derivatives as antihistaminic and anti-allergic agents.
BG106168A BG106168A (bg) 1999-06-04 2001-12-03 Индолилпиперидинови производни като антихистаминови и антиалергични средства
NO20015897A NO20015897L (no) 1999-06-04 2001-12-03 Indolylpiperidinderivater som antihistaminiske og antiallergiske midler
US10/006,416 US6683096B2 (en) 1999-06-04 2001-12-04 Indolylpiperidine derivatives as antihistaminic and antiallergic agents
HK02102119.0A HK1040990A1 (zh) 1999-06-04 2002-03-20 作為抗組胺劑和抗過敏劑的吲基哌啶衍生物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901232A ES2165274B1 (es) 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Publications (2)

Publication Number Publication Date
ES2165274A1 true ES2165274A1 (es) 2002-03-01
ES2165274B1 ES2165274B1 (es) 2003-04-01

Family

ID=8308707

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009901232A Expired - Fee Related ES2165274B1 (es) 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
ES00940296T Expired - Lifetime ES2211559T3 (es) 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes anhistaminicos y antialergicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00940296T Expired - Lifetime ES2211559T3 (es) 1999-06-04 2000-05-31 Derivados de indolilpiperidina como agentes anhistaminicos y antialergicos.

Country Status (35)

Country Link
US (1) US6683096B2 (es)
EP (1) EP1183251B1 (es)
JP (1) JP2003501424A (es)
KR (1) KR100683454B1 (es)
CN (1) CN1191246C (es)
AR (1) AR029640A1 (es)
AT (1) ATE259362T1 (es)
AU (1) AU773164B2 (es)
BG (1) BG106168A (es)
BR (1) BR0011340A (es)
CA (1) CA2375985A1 (es)
CO (1) CO5180556A1 (es)
CZ (1) CZ20014334A3 (es)
DE (1) DE60008239T2 (es)
DK (1) DK1183251T3 (es)
EE (1) EE04717B1 (es)
ES (2) ES2165274B1 (es)
HK (1) HK1040990A1 (es)
HU (1) HUP0203320A3 (es)
IL (1) IL146629A0 (es)
MX (1) MXPA01012425A (es)
MY (1) MY127033A (es)
NO (1) NO20015897L (es)
NZ (1) NZ515649A (es)
PE (1) PE20010208A1 (es)
PL (1) PL196774B1 (es)
PT (1) PT1183251E (es)
RU (1) RU2246493C2 (es)
SI (1) SI1183251T1 (es)
SK (1) SK17042001A3 (es)
TR (1) TR200103490T2 (es)
TW (1) TWI226889B (es)
UA (1) UA72517C2 (es)
WO (1) WO2000075130A1 (es)
ZA (1) ZA200109676B (es)

Families Citing this family (21)

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BR0107624A (pt) 2000-01-17 2002-11-12 Bayer Ag Arilcetonas substituìdas
ES2172436B1 (es) 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU2002243394A1 (en) * 2000-11-16 2002-06-24 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
ES2201899B1 (es) * 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES2201907B1 (es) * 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
CN1882565A (zh) 2003-11-17 2006-12-20 贝林格尔.英格海姆国际有限公司 哌啶取代的吲哚或其杂环衍生物以及它们作为趋化因子－受体(ccr－3)调节剂的用途
US20050245540A1 (en) * 2003-12-09 2005-11-03 Fujisawa Pharmaceutical Co., Ltd. New methods
WO2005101838A2 (en) 2004-04-13 2005-10-27 Incyte Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
NZ551603A (en) 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
US20060009491A1 (en) * 2004-06-24 2006-01-12 Incyte Corporation Amido compounds and their use as pharmaceuticals
DE602006012650D1 (de) * 2005-04-26 2010-04-15 Hypnion Inc Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung
CA2606550C (en) 2005-04-30 2014-05-27 Boehringer Ingelheim International Gmbh Piperidine-substituted indoles
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
WO2008030853A2 (en) * 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
ATE537166T1 (de) * 2006-10-27 2011-12-15 Boehringer Ingelheim Int Piperidylpropanthiole als ccr3-modulatoren
SG182205A1 (en) 2007-03-15 2012-07-30 Novartis Ag Organic compounds and their uses
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN101560179B (zh) * 2009-05-25 2012-04-18 浙江大学 具有h3受体亲和能力的含氮吲哚衍生物和用途
CN101747321B (zh) * 2009-12-22 2013-01-02 浙江大学 吲哚-3-苄胺衍生物及制备方法和用途
EP3040334A1 (en) * 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
IL310330A (en) * 2021-07-30 2024-03-01 Confo Therapeutics N V Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders associated with AT2R and/or AT2R-mediated signaling

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EP0224919A2 (en) * 1985-12-05 1987-06-10 Fujisawa Pharmaceutical Co., Ltd. New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
EP0324431A1 (en) * 1988-01-14 1989-07-19 Fujisawa Pharmaceutical Co., Ltd. New indolylpiperidine compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
EP0378255A2 (en) * 1989-01-09 1990-07-18 Janssen Pharmaceutica N.V. 2-Aminopyrimidinone derivatives
EP0648759A1 (en) * 1993-10-15 1995-04-19 ERREGIERRE S.p.A. Antihistaminic compounds, process for their preparation and pharmaceutical compositions containing them

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PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
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DE19707628A1 (de) 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol

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Publication number Priority date Publication date Assignee Title
EP0224919A2 (en) * 1985-12-05 1987-06-10 Fujisawa Pharmaceutical Co., Ltd. New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
EP0324431A1 (en) * 1988-01-14 1989-07-19 Fujisawa Pharmaceutical Co., Ltd. New indolylpiperidine compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
EP0378255A2 (en) * 1989-01-09 1990-07-18 Janssen Pharmaceutica N.V. 2-Aminopyrimidinone derivatives
EP0648759A1 (en) * 1993-10-15 1995-04-19 ERREGIERRE S.p.A. Antihistaminic compounds, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EE200100653A (et) 2003-02-17
ES2165274B1 (es) 2003-04-01
NO20015897D0 (no) 2001-12-03
DE60008239D1 (de) 2004-03-18
ZA200109676B (en) 2003-02-24
UA72517C2 (uk) 2005-03-15
JP2003501424A (ja) 2003-01-14
RU2002100073A (ru) 2004-01-10
DE60008239T2 (de) 2004-11-18
US20020147344A1 (en) 2002-10-10
CO5180556A1 (es) 2002-07-30
US6683096B2 (en) 2004-01-27
HK1040990A1 (zh) 2002-06-28
MXPA01012425A (es) 2002-06-04
EP1183251A1 (en) 2002-03-06
PE20010208A1 (es) 2001-03-19
SK17042001A3 (sk) 2002-04-04
SI1183251T1 (en) 2004-06-30
EE04717B1 (et) 2006-10-16
CN1191246C (zh) 2005-03-02
ATE259362T1 (de) 2004-02-15
AU773164B2 (en) 2004-05-20
CZ20014334A3 (cs) 2002-03-13
KR20020020721A (ko) 2002-03-15
NO20015897L (no) 2001-12-03
ES2211559T3 (es) 2004-07-16
EP1183251B1 (en) 2004-02-11
PL353164A1 (en) 2003-10-20
BG106168A (bg) 2002-07-31
PT1183251E (pt) 2004-05-31
AU5527600A (en) 2000-12-28
CA2375985A1 (en) 2000-12-14
NZ515649A (en) 2003-08-29
KR100683454B1 (ko) 2007-02-20
AR029640A1 (es) 2003-07-10
BR0011340A (pt) 2002-03-05
HUP0203320A2 (hu) 2003-02-28
HUP0203320A3 (en) 2004-01-28
DK1183251T3 (da) 2004-06-07
IL146629A0 (en) 2002-07-25
RU2246493C2 (ru) 2005-02-20
TR200103490T2 (tr) 2002-04-22
TWI226889B (en) 2005-01-21
PL196774B1 (pl) 2008-01-31
CN1368969A (zh) 2002-09-11
MY127033A (en) 2006-11-30
WO2000075130A1 (en) 2000-12-14

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