AR031168A1 - Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos - Google Patents
Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicosInfo
- Publication number
- AR031168A1 AR031168A1 ARP010105068A ARP010105068A AR031168A1 AR 031168 A1 AR031168 A1 AR 031168A1 AR P010105068 A ARP010105068 A AR P010105068A AR P010105068 A ARP010105068 A AR P010105068A AR 031168 A1 AR031168 A1 AR 031168A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkylene
- alkoxy
- alkyl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a los derivados de indolil piperidinil de la formula (1), donde A1 representa un grupo alquileno, alquilenoxi, alquilentio, alcanoileno o hidroxialquileno; A2 representa un grupo alquileno, alquilenoxi, alquilentio, alcanoileno o alquilenoxialquileno; W1 representa un grupo fenileno, furanileno o piridinileno que es substituido o no substituido por uno o más átomos halogeno, grupos alcoxi y/o grupos alquilo; W2 representa un grupo de 3-10 miembros monocíclico o bicíclico que contiene desde 1 a 3 hetero-átomos, siendo dicho grupo substituido o no substituido por uno o más átomos de halogeno, grupo alquilo, grupo alcoxi y/o grupos oxo; R1 representa un átomo de hidrogeno o halogeno o un grupo alquilo, alcoxi o metilamino; y R2 representa un grupo carboxilo, y las sales farmacéuticamente aceptables de los mismos; a los procesos para su preparacion; a las composiciones farmacéuticas que los contienen; y a su uso médico como agentes antihistamínicos y antialérgicos..
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002615A ES2172436B1 (es) | 2000-10-31 | 2000-10-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR031168A1 true AR031168A1 (es) | 2003-09-10 |
Family
ID=8495472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010105068A AR031168A1 (es) | 2000-10-31 | 2001-10-30 | Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos |
Country Status (16)
Country | Link |
---|---|
US (1) | US7189741B2 (es) |
EP (1) | EP1330453B1 (es) |
JP (1) | JP4184785B2 (es) |
AR (1) | AR031168A1 (es) |
AT (1) | ATE321761T1 (es) |
AU (1) | AU2002223655A1 (es) |
CA (1) | CA2427589A1 (es) |
DE (1) | DE60118434T2 (es) |
DK (1) | DK1330453T3 (es) |
ES (2) | ES2172436B1 (es) |
MY (1) | MY155914A (es) |
PE (1) | PE20020543A1 (es) |
PT (1) | PT1330453E (es) |
SI (1) | SI1330453T1 (es) |
UY (1) | UY27001A1 (es) |
WO (1) | WO2002036589A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
ES2201907B1 (es) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos. |
JP4326468B2 (ja) * | 2002-06-24 | 2009-09-09 | シェーリング コーポレイション | ヒスタミンh3アンタゴニストとして有用なインドール誘導体 |
WO2004047769A2 (en) * | 2002-11-26 | 2004-06-10 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antibacterials |
US20080015214A1 (en) * | 2005-10-24 | 2008-01-17 | Bignan Gilles C | 3-piperidin-4-yl-indole orl-1 receptor modulators |
JP5581055B2 (ja) * | 2006-10-27 | 2014-08-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピペリジル−プロパン−チオールccr3モジュレーター |
PE20090188A1 (es) * | 2007-03-15 | 2009-03-20 | Novartis Ag | Compuestos heterociclicos como moduladores de la senda de hedgehog |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK471479A (da) | 1978-12-13 | 1980-06-14 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
US4843068A (en) | 1985-12-27 | 1989-06-27 | Nihon Nohyaku Co., Ltd. | Pyrazole oxime derivatives and compositions |
DK733788A (da) | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
CA2129995C (en) * | 1992-02-13 | 2000-04-11 | Albert A. Carr | Piperidinyl thiacyclic derivatives |
JP3338913B2 (ja) * | 1993-06-29 | 2002-10-28 | 大鵬薬品工業株式会社 | テトラゾール誘導体 |
IT1271417B (it) | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono. |
DE19500689A1 (de) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
DE19707628A1 (de) | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
ES2165274B1 (es) | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
AR028685A1 (es) | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
-
2000
- 2000-10-31 ES ES200002615A patent/ES2172436B1/es not_active Expired - Fee Related
-
2001
- 2001-10-26 AU AU2002223655A patent/AU2002223655A1/en not_active Abandoned
- 2001-10-26 AT AT01992709T patent/ATE321761T1/de not_active IP Right Cessation
- 2001-10-26 DE DE60118434T patent/DE60118434T2/de not_active Expired - Lifetime
- 2001-10-26 DK DK01992709T patent/DK1330453T3/da active
- 2001-10-26 EP EP01992709A patent/EP1330453B1/en not_active Expired - Lifetime
- 2001-10-26 US US10/415,693 patent/US7189741B2/en not_active Expired - Fee Related
- 2001-10-26 ES ES01992709T patent/ES2259052T3/es not_active Expired - Lifetime
- 2001-10-26 SI SI200130521T patent/SI1330453T1/sl unknown
- 2001-10-26 WO PCT/EP2001/012450 patent/WO2002036589A1/en active IP Right Grant
- 2001-10-26 JP JP2002539348A patent/JP4184785B2/ja not_active Expired - Fee Related
- 2001-10-26 CA CA002427589A patent/CA2427589A1/en not_active Abandoned
- 2001-10-26 PT PT01992709T patent/PT1330453E/pt unknown
- 2001-10-30 MY MYPI20015021A patent/MY155914A/en unknown
- 2001-10-30 AR ARP010105068A patent/AR031168A1/es not_active Application Discontinuation
- 2001-10-30 PE PE2001001079A patent/PE20020543A1/es not_active Application Discontinuation
- 2001-10-31 UY UY27001A patent/UY27001A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
ES2172436B1 (es) | 2004-01-16 |
DE60118434D1 (de) | 2006-05-18 |
ATE321761T1 (de) | 2006-04-15 |
DE60118434T2 (de) | 2006-12-14 |
EP1330453A1 (en) | 2003-07-30 |
PT1330453E (pt) | 2006-07-31 |
JP4184785B2 (ja) | 2008-11-19 |
CA2427589A1 (en) | 2002-05-10 |
PE20020543A1 (es) | 2002-07-17 |
ES2259052T3 (es) | 2006-09-16 |
WO2002036589A1 (en) | 2002-05-10 |
SI1330453T1 (sl) | 2006-08-31 |
DK1330453T3 (da) | 2006-08-07 |
UY27001A1 (es) | 2001-12-28 |
US20040116471A1 (en) | 2004-06-17 |
US7189741B2 (en) | 2007-03-13 |
AU2002223655A1 (en) | 2002-05-15 |
JP2004513127A (ja) | 2004-04-30 |
EP1330453B1 (en) | 2006-03-29 |
ES2172436A1 (es) | 2002-09-16 |
MY155914A (en) | 2015-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |