BR0111976A - Preparação terapêutica para neurose ou depressão por ansiedade, e, derivado de piperazina - Google Patents
Preparação terapêutica para neurose ou depressão por ansiedade, e, derivado de piperazinaInfo
- Publication number
- BR0111976A BR0111976A BR0111976-1A BR0111976A BR0111976A BR 0111976 A BR0111976 A BR 0111976A BR 0111976 A BR0111976 A BR 0111976A BR 0111976 A BR0111976 A BR 0111976A
- Authority
- BR
- Brazil
- Prior art keywords
- depression
- hydrogen
- therapeutic preparation
- formula
- piperazine derivative
- Prior art date
Links
- 208000019901 Anxiety disease Diseases 0.000 title abstract 2
- 208000020401 Depressive disease Diseases 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 206010029333 Neurosis Diseases 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000015238 neurotic disease Diseases 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 abstract 1
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical class C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 abstract 1
- 229940075559 piperine Drugs 0.000 abstract 1
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 abstract 1
- 235000019100 piperine Nutrition 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PREPARAçãO TERAPêUTICA PARA NEUROSE OU DEPRESSãO POR ANSIEDADE, E, DERIVADO DE PIPERAZINA". Um remédio para neurose ou depressão por ansiedade, que contém um antagonista receptor de MC4 como ingrediente ativo; e um derivado de piperazina, representado pela fórmula (1) ou um seu sal farmaceuticamente aceitável, em que Ar' representa fenila (in)substituída etc.; Ar2 representa (in)substituída fenila, quinolila, um grupo representado pela fórmula (a) (em que R4 é um hidrogênio ou halogênio; e X-Y é CH-NH, CH-O, CH-S ou N-O), ou um grupo representado pela fórmula (b) (em que R^ 5^ é um átomo de hidrogênio, um grupo hidroxila ou um grupo C~ 1-10~ alcóxi); R^ 1^ representa hidrogênio, C~ 1-10~ alquila etc.; R^ 2^ e R^ 3^ são iguais ou diferentes e cada um é hidrogênio ou C~ 1-10~ alquila; A-B representa N-CH~ 2~, CH-CH~ 2~, C(OH)CH~ 2~ ou C=CH; T^ 1^ representa uma ligação simples, -N(R^ 6^)- (em que é um átomo de hidrogênio ou um gupo C~ 1-10~ alquila), -O-, -CH=CH- ou -C(=O)-, n é um inteiro de 1 a 10 e quando T^ 1^ for uma ligação simples, -CH=CH- ou -C(=O)-, n é um inteiro de 2 a 10 quando T^ 1^ for -N(R^ 6^)- ou -O-, ou um seu sal farmaceuticamente aceitável.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000192856 | 2000-06-27 | ||
PCT/JP2001/005524 WO2002000259A1 (fr) | 2000-06-27 | 2001-06-27 | Agent therapeutique contre l'anxiete nevrotique ou la depression et derive de piperazine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0111976A true BR0111976A (pt) | 2003-12-09 |
Family
ID=18691931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0111976-1A BR0111976A (pt) | 2000-06-27 | 2001-06-27 | Preparação terapêutica para neurose ou depressão por ansiedade, e, derivado de piperazina |
Country Status (22)
Country | Link |
---|---|
US (1) | US6949552B2 (pt) |
EP (1) | EP1295608A4 (pt) |
JP (1) | JP5002881B2 (pt) |
KR (1) | KR20030013470A (pt) |
CN (1) | CN1438897A (pt) |
AU (2) | AU6634201A (pt) |
BG (1) | BG107371A (pt) |
BR (1) | BR0111976A (pt) |
CA (1) | CA2413506A1 (pt) |
CZ (1) | CZ20024165A3 (pt) |
EA (2) | EA200500087A1 (pt) |
EE (1) | EE200200717A (pt) |
HR (1) | HRP20030056A2 (pt) |
HU (1) | HUP0301719A2 (pt) |
IL (1) | IL153706A0 (pt) |
MX (1) | MXPA02012707A (pt) |
NO (1) | NO20026122L (pt) |
NZ (1) | NZ523800A (pt) |
PL (1) | PL360286A1 (pt) |
SK (1) | SK18322002A3 (pt) |
WO (1) | WO2002000259A1 (pt) |
ZA (1) | ZA200210386B (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL360286A1 (en) | 2000-06-27 | 2004-09-06 | Taisho Pharmaceutical Co.Ltd. | Remedial agent for anxiety neurosis or depression and piperazine derivative |
EP1425029A4 (en) | 2001-08-10 | 2006-06-07 | Palatin Technologies Inc | PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES |
US7732451B2 (en) | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
JPWO2003053927A1 (ja) * | 2001-12-21 | 2005-04-28 | 大正製薬株式会社 | ピペラジン誘導体 |
US7968548B2 (en) * | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
US7491723B2 (en) | 2003-10-14 | 2009-02-17 | Wyeth | Alkanol and cycloalkanol-amine derivatives and methods of their use |
US7419980B2 (en) * | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
AR054435A1 (es) * | 2005-04-04 | 2007-06-27 | Takeda Pharmaceutical | Agente para profilaxis o terapia contra la depresion o desorden de ansiedad |
US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
WO2008039863A2 (en) * | 2006-09-27 | 2008-04-03 | Braincells, Inc. | Composition comprising a melanocortin receptor (mcr) modulating agent alone or in combination with a second neurogenic agent for treating nervous system disorders |
EP2072050A1 (en) | 2007-12-21 | 2009-06-24 | Santhera Pharmaceuticals (Schweiz) AG | Compounds with anti-emetic effect |
JP2013503835A (ja) | 2009-09-07 | 2013-02-04 | ヴィフォール (インターナショナル) アクチェンゲゼルシャフト | 新規なエタンジアミン系ヘプシジン拮抗薬 |
WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
CA2825098C (en) | 2011-01-27 | 2020-03-10 | Universite De Montreal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1317053A (fr) * | 1961-03-17 | 1963-02-01 | Soc Ind Fab Antibiotiques Sifa | Nouveaux dérivés de la pipérazine, et procédé de préparation |
CA918659A (en) * | 1969-07-31 | 1973-01-09 | Yoshitomi Pharmaceutical Industries | 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines |
FR2601364B1 (fr) * | 1986-07-09 | 1988-10-21 | Adir | Nouveaux derives de la piperazine dione-2,6, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
GB9021453D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
JPH0641071A (ja) * | 1991-09-06 | 1994-02-15 | Taisho Pharmaceut Co Ltd | インドール酢酸エステル誘導体 |
GB9200293D0 (en) * | 1992-01-08 | 1992-02-26 | Wyeth John & Brother Ltd | Piperazine derivatives |
SE9700620D0 (sv) * | 1997-02-21 | 1997-02-21 | Wapharm Ab | Cykliska peptider med selektivitet för MSH-receptor subtyper |
AU742425B2 (en) | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
PL360286A1 (en) | 2000-06-27 | 2004-09-06 | Taisho Pharmaceutical Co.Ltd. | Remedial agent for anxiety neurosis or depression and piperazine derivative |
-
2001
- 2001-06-27 PL PL36028601A patent/PL360286A1/xx not_active Application Discontinuation
- 2001-06-27 EA EA200500087A patent/EA200500087A1/ru unknown
- 2001-06-27 CZ CZ20024165A patent/CZ20024165A3/cs unknown
- 2001-06-27 IL IL15370601A patent/IL153706A0/xx unknown
- 2001-06-27 BR BR0111976-1A patent/BR0111976A/pt not_active IP Right Cessation
- 2001-06-27 WO PCT/JP2001/005524 patent/WO2002000259A1/ja not_active Application Discontinuation
- 2001-06-27 EE EEP200200717A patent/EE200200717A/xx unknown
- 2001-06-27 AU AU6634201A patent/AU6634201A/xx not_active Withdrawn
- 2001-06-27 JP JP2002505040A patent/JP5002881B2/ja not_active Expired - Fee Related
- 2001-06-27 CN CN01811767A patent/CN1438897A/zh active Pending
- 2001-06-27 EP EP01943844A patent/EP1295608A4/en not_active Withdrawn
- 2001-06-27 US US10/311,429 patent/US6949552B2/en not_active Expired - Fee Related
- 2001-06-27 HU HU0301719A patent/HUP0301719A2/hu unknown
- 2001-06-27 MX MXPA02012707A patent/MXPA02012707A/es unknown
- 2001-06-27 AU AU2001266342A patent/AU2001266342B2/en not_active Ceased
- 2001-06-27 NZ NZ523800A patent/NZ523800A/en unknown
- 2001-06-27 CA CA002413506A patent/CA2413506A1/en not_active Abandoned
- 2001-06-27 KR KR1020027017682A patent/KR20030013470A/ko not_active Application Discontinuation
- 2001-06-27 SK SK1832-2002A patent/SK18322002A3/sk unknown
- 2001-06-27 EA EA200300071A patent/EA005737B1/ru not_active IP Right Cessation
-
2002
- 2002-12-11 BG BG107371A patent/BG107371A/bg unknown
- 2002-12-19 NO NO20026122A patent/NO20026122L/no not_active Application Discontinuation
- 2002-12-20 ZA ZA200210386A patent/ZA200210386B/en unknown
-
2003
- 2003-01-27 HR HR20030056A patent/HRP20030056A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1295608A4 (en) | 2004-03-31 |
EA200300071A1 (ru) | 2003-06-26 |
EP1295608A1 (en) | 2003-03-26 |
HRP20030056A2 (en) | 2005-02-28 |
BG107371A (bg) | 2003-08-29 |
HUP0301719A2 (hu) | 2003-09-29 |
PL360286A1 (en) | 2004-09-06 |
AU2001266342B2 (en) | 2005-01-27 |
NO20026122D0 (no) | 2002-12-19 |
WO2002000259A1 (fr) | 2002-01-03 |
EA005737B1 (ru) | 2005-06-30 |
SK18322002A3 (sk) | 2003-09-11 |
NO20026122L (no) | 2003-02-25 |
IL153706A0 (en) | 2003-07-06 |
US6949552B2 (en) | 2005-09-27 |
US20030186992A1 (en) | 2003-10-02 |
EA200500087A1 (ru) | 2005-06-30 |
CN1438897A (zh) | 2003-08-27 |
KR20030013470A (ko) | 2003-02-14 |
CA2413506A1 (en) | 2002-12-20 |
EE200200717A (et) | 2004-08-16 |
ZA200210386B (en) | 2004-02-10 |
JP5002881B2 (ja) | 2012-08-15 |
AU6634201A (en) | 2002-01-08 |
CZ20024165A3 (cs) | 2004-03-17 |
NZ523800A (en) | 2005-02-25 |
MXPA02012707A (es) | 2003-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009. |