EA200300071A1 - Терапевтический препарат для лечения невроза страха (тревоги) или депрессии и производные пиперазина - Google Patents
Терапевтический препарат для лечения невроза страха (тревоги) или депрессии и производные пиперазинаInfo
- Publication number
- EA200300071A1 EA200300071A1 EA200300071A EA200300071A EA200300071A1 EA 200300071 A1 EA200300071 A1 EA 200300071A1 EA 200300071 A EA200300071 A EA 200300071A EA 200300071 A EA200300071 A EA 200300071A EA 200300071 A1 EA200300071 A1 EA 200300071A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- hydrogen atom
- formula
- treatment
- piperazine
- Prior art date
Links
- 206010029333 Neurosis Diseases 0.000 title abstract 2
- 208000015238 neurotic disease Diseases 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000001624 naphthyl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- -1 1-cyanoethyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 108010030017 midkine receptors Proteins 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Представлен терапевтический препарат для лечения невроза страха или депрессии, который содержит антагонист рецептора MKв качестве эффективного ингредиента; и производное пиперазина, представленное формулой [1][где Arявляется фенильной группой, замещенной фенильной группой, нафтильной группой или замещенной нафтильной группой;Arявляется нафтильной группой, замещенной нафтильной группой, хинолильной группой, группой, представленной формулой(где Rявляется атомом водорода или атомом галогена; и X-Y является CH-NH, CH-O, CH-S или N-O) или группой, представленной формулой(где Rявляется атомом водорода, гидроксильной группой или Cалкоксигруппой);Rявляется атомом водорода, Cалкильной группой, Cциклоалкильной группой, Cалкенильной группой, фенильной группой, 1-цианоэтильной группой, пиримидин-2-ильной группой или амидильной группой; Rи Rявляются одинаковыми или разными и каждый является атомом водорода или Cалкильной группой; A-B является N-CH, CH-CH, C(OH)-CHили C=CH; Tявляется одинарной связью, -N(R)- (где Rявляется атомом водорода или Cалкильной группой), -O-, -CH=CH- или -C(=O)-; n является целым числом от 1 до 10, если Tявляется одинарной связью, -CH=CH- или -C(=O)-, и n является целым числом от 2 до 10, если Tявляется -N(R)- или -O-], или его фармацевтически приемлемая соль.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000192856 | 2000-06-27 | ||
PCT/JP2001/005524 WO2002000259A1 (fr) | 2000-06-27 | 2001-06-27 | Agent therapeutique contre l'anxiete nevrotique ou la depression et derive de piperazine |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200300071A1 true EA200300071A1 (ru) | 2003-06-26 |
EA005737B1 EA005737B1 (ru) | 2005-06-30 |
Family
ID=18691931
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500087A EA200500087A1 (ru) | 2000-06-27 | 2001-06-27 | Производные пиперазина |
EA200300071A EA005737B1 (ru) | 2000-06-27 | 2001-06-27 | Терапевтический препарат для лечения невроза страха (тревоги) или депрессии |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500087A EA200500087A1 (ru) | 2000-06-27 | 2001-06-27 | Производные пиперазина |
Country Status (22)
Country | Link |
---|---|
US (1) | US6949552B2 (ru) |
EP (1) | EP1295608A4 (ru) |
JP (1) | JP5002881B2 (ru) |
KR (1) | KR20030013470A (ru) |
CN (1) | CN1438897A (ru) |
AU (2) | AU2001266342B2 (ru) |
BG (1) | BG107371A (ru) |
BR (1) | BR0111976A (ru) |
CA (1) | CA2413506A1 (ru) |
CZ (1) | CZ20024165A3 (ru) |
EA (2) | EA200500087A1 (ru) |
EE (1) | EE200200717A (ru) |
HR (1) | HRP20030056A2 (ru) |
HU (1) | HUP0301719A2 (ru) |
IL (1) | IL153706A0 (ru) |
MX (1) | MXPA02012707A (ru) |
NO (1) | NO20026122L (ru) |
NZ (1) | NZ523800A (ru) |
PL (1) | PL360286A1 (ru) |
SK (1) | SK18322002A3 (ru) |
WO (1) | WO2002000259A1 (ru) |
ZA (1) | ZA200210386B (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200500087A1 (ru) | 2000-06-27 | 2005-06-30 | Тайсо Фармасьютикал Ко., Лтд. | Производные пиперазина |
US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
AU2002331064B2 (en) | 2001-08-10 | 2007-08-23 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
US7732451B2 (en) | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
EP1468990A4 (en) * | 2001-12-21 | 2006-01-04 | Taisho Pharmaceutical Co Ltd | piperazine derivative |
US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
US7968548B2 (en) * | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
US7419980B2 (en) * | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
US7491723B2 (en) | 2003-10-14 | 2009-02-17 | Wyeth | Alkanol and cycloalkanol-amine derivatives and methods of their use |
US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
JP5259181B2 (ja) * | 2005-04-04 | 2013-08-07 | 武田薬品工業株式会社 | うつ病または不安神経症の予防または治療剤 |
US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
WO2008039863A2 (en) * | 2006-09-27 | 2008-04-03 | Braincells, Inc. | Composition comprising a melanocortin receptor (mcr) modulating agent alone or in combination with a second neurogenic agent for treating nervous system disorders |
EP2072050A1 (en) * | 2007-12-21 | 2009-06-24 | Santhera Pharmaceuticals (Schweiz) AG | Compounds with anti-emetic effect |
TW201113274A (en) | 2009-09-07 | 2011-04-16 | Vifor Int Ag | Novel ethanediamine hepcidine antagonists |
US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
CA2825098C (en) | 2011-01-27 | 2020-03-10 | Universite De Montreal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1317053A (fr) | 1961-03-17 | 1963-02-01 | Soc Ind Fab Antibiotiques Sifa | Nouveaux dérivés de la pipérazine, et procédé de préparation |
CA918659A (en) | 1969-07-31 | 1973-01-09 | Yoshitomi Pharmaceutical Industries | 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines |
FR2601364B1 (fr) * | 1986-07-09 | 1988-10-21 | Adir | Nouveaux derives de la piperazine dione-2,6, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
GB9021453D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
JPH0641071A (ja) * | 1991-09-06 | 1994-02-15 | Taisho Pharmaceut Co Ltd | インドール酢酸エステル誘導体 |
GB9200293D0 (en) * | 1992-01-08 | 1992-02-26 | Wyeth John & Brother Ltd | Piperazine derivatives |
SE9700620D0 (sv) * | 1997-02-21 | 1997-02-21 | Wapharm Ab | Cykliska peptider med selektivitet för MSH-receptor subtyper |
WO1999064002A1 (en) * | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
EA200500087A1 (ru) | 2000-06-27 | 2005-06-30 | Тайсо Фармасьютикал Ко., Лтд. | Производные пиперазина |
-
2001
- 2001-06-27 EA EA200500087A patent/EA200500087A1/ru unknown
- 2001-06-27 MX MXPA02012707A patent/MXPA02012707A/es unknown
- 2001-06-27 US US10/311,429 patent/US6949552B2/en not_active Expired - Fee Related
- 2001-06-27 EP EP01943844A patent/EP1295608A4/en not_active Withdrawn
- 2001-06-27 AU AU2001266342A patent/AU2001266342B2/en not_active Ceased
- 2001-06-27 HU HU0301719A patent/HUP0301719A2/hu unknown
- 2001-06-27 PL PL36028601A patent/PL360286A1/xx not_active Application Discontinuation
- 2001-06-27 CA CA002413506A patent/CA2413506A1/en not_active Abandoned
- 2001-06-27 EA EA200300071A patent/EA005737B1/ru not_active IP Right Cessation
- 2001-06-27 KR KR1020027017682A patent/KR20030013470A/ko not_active Application Discontinuation
- 2001-06-27 EE EEP200200717A patent/EE200200717A/xx unknown
- 2001-06-27 AU AU6634201A patent/AU6634201A/xx not_active Withdrawn
- 2001-06-27 IL IL15370601A patent/IL153706A0/xx unknown
- 2001-06-27 WO PCT/JP2001/005524 patent/WO2002000259A1/ja not_active Application Discontinuation
- 2001-06-27 SK SK1832-2002A patent/SK18322002A3/sk unknown
- 2001-06-27 CZ CZ20024165A patent/CZ20024165A3/cs unknown
- 2001-06-27 CN CN01811767A patent/CN1438897A/zh active Pending
- 2001-06-27 JP JP2002505040A patent/JP5002881B2/ja not_active Expired - Fee Related
- 2001-06-27 BR BR0111976-1A patent/BR0111976A/pt not_active IP Right Cessation
- 2001-06-27 NZ NZ523800A patent/NZ523800A/en unknown
-
2002
- 2002-12-11 BG BG107371A patent/BG107371A/bg unknown
- 2002-12-19 NO NO20026122A patent/NO20026122L/no not_active Application Discontinuation
- 2002-12-20 ZA ZA200210386A patent/ZA200210386B/en unknown
-
2003
- 2003-01-27 HR HR20030056A patent/HRP20030056A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1438897A (zh) | 2003-08-27 |
HRP20030056A2 (en) | 2005-02-28 |
BG107371A (bg) | 2003-08-29 |
EA005737B1 (ru) | 2005-06-30 |
NZ523800A (en) | 2005-02-25 |
AU6634201A (en) | 2002-01-08 |
EP1295608A1 (en) | 2003-03-26 |
CZ20024165A3 (cs) | 2004-03-17 |
CA2413506A1 (en) | 2002-12-20 |
KR20030013470A (ko) | 2003-02-14 |
AU2001266342B2 (en) | 2005-01-27 |
EE200200717A (et) | 2004-08-16 |
WO2002000259A1 (fr) | 2002-01-03 |
BR0111976A (pt) | 2003-12-09 |
EP1295608A4 (en) | 2004-03-31 |
US20030186992A1 (en) | 2003-10-02 |
SK18322002A3 (sk) | 2003-09-11 |
US6949552B2 (en) | 2005-09-27 |
ZA200210386B (en) | 2004-02-10 |
EA200500087A1 (ru) | 2005-06-30 |
MXPA02012707A (es) | 2003-04-25 |
HUP0301719A2 (hu) | 2003-09-29 |
NO20026122D0 (no) | 2002-12-19 |
NO20026122L (no) | 2003-02-25 |
PL360286A1 (en) | 2004-09-06 |
IL153706A0 (en) | 2003-07-06 |
JP5002881B2 (ja) | 2012-08-15 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |