DK1226819T3 - Inhibitor for 20-HETE-producerende enzym - Google Patents

Inhibitor for 20-HETE-producerende enzym

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Publication number
DK1226819T3
DK1226819T3 DK00971721T DK00971721T DK1226819T3 DK 1226819 T3 DK1226819 T3 DK 1226819T3 DK 00971721 T DK00971721 T DK 00971721T DK 00971721 T DK00971721 T DK 00971721T DK 1226819 T3 DK1226819 T3 DK 1226819T3
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DK
Denmark
Prior art keywords
inhibitor
present
hete
producing enzyme
pharmaceutically
Prior art date
Application number
DK00971721T
Other languages
English (en)
Inventor
Masakazu Sato
Noriyuki Miyata
Takaaki Ishii
Yuko Kobayashi
Hideaki Amada
Original Assignee
Taisho Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
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Publication of DK1226819T3 publication Critical patent/DK1226819T3/da

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/18—Sulfonamides
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
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    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
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    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
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DK00971721T 1999-11-01 2000-11-01 Inhibitor for 20-HETE-producerende enzym DK1226819T3 (da)

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US7214714B2 (en) 2001-04-26 2007-05-08 Taisho Pharmaceutical Co. Ltd. 20-hydroxyeicosatetraenoic acid production inhibitors
US6818662B2 (en) 2002-05-28 2004-11-16 Taisho Pharmaceutical Co., Ltd. Pharmaceutical composition
US7288566B2 (en) 2002-09-12 2007-10-30 Taisho Pharmaceutical Co., Ltd. N-hydroxyformamidine derivatives
JP2008230968A (ja) * 2005-06-30 2008-10-02 Taisho Pharmaceutical Co Ltd 脳梗塞治療用の医薬
WO2008034011A2 (en) 2006-09-13 2008-03-20 Mcw Research Foundation, Inc. Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases
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US4237168A (en) * 1979-06-11 1980-12-02 The Dow Chemical Company N-(4-Chloro-2-methylphenyl)-N-hydroxy methanimidamide and its pesticidal use
IT1209431B (it) * 1980-11-28 1989-07-16 Angeli Inst Spa Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.
AU3022984A (en) * 1983-07-15 1985-01-17 Nippon Soda Co., Ltd. Formamidoxime derivatives
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US6864254B1 (en) 2005-03-08
CY1105591T1 (el) 2010-07-28
DE60025644T8 (de) 2007-03-29
DE60025644T2 (de) 2006-09-07
US7078400B2 (en) 2006-07-18
AU1053301A (en) 2001-05-14
HK1050141A1 (en) 2003-06-13
KR100785148B1 (ko) 2007-12-11
EP1226819A1 (en) 2002-07-31
ES2256053T3 (es) 2006-07-16
EP1226819B1 (en) 2006-01-18
KR20020050248A (ko) 2002-06-26
CN1250209C (zh) 2006-04-12
KR100767508B1 (ko) 2007-10-17
KR20070087044A (ko) 2007-08-27
CA2389378C (en) 2009-11-24
DE60025644D1 (de) 2006-04-06
CN1382045A (zh) 2002-11-27
ATE315932T1 (de) 2006-02-15
CA2389378A1 (en) 2001-05-10
AU759604B2 (en) 2003-04-17

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