DE60025644D1 - Hemmer für das 20-hete-produzierende enzym - Google Patents

Hemmer für das 20-hete-produzierende enzym

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Publication number
DE60025644D1
DE60025644D1 DE60025644T DE60025644T DE60025644D1 DE 60025644 D1 DE60025644 D1 DE 60025644D1 DE 60025644 T DE60025644 T DE 60025644T DE 60025644 T DE60025644 T DE 60025644T DE 60025644 D1 DE60025644 D1 DE 60025644D1
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DE
Germany
Prior art keywords
produzenenz
hemmer
hete
enzym
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60025644T
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English (en)
Other versions
DE60025644T2 (de
DE60025644T8 (de
Inventor
Masakazu Sato
Noriyuki Miyata
Takaaki Ishii
Yuko Kobayashi
Hideaki Amada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of DE60025644D1 publication Critical patent/DE60025644D1/de
Publication of DE60025644T2 publication Critical patent/DE60025644T2/de
Application granted granted Critical
Publication of DE60025644T8 publication Critical patent/DE60025644T8/de
Active legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
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    • A61K31/275—Nitriles; Isonitriles
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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DE60025644T 1999-11-01 2000-11-01 Hemmer für das 20-hete-produzierende enzym Active DE60025644T8 (de)

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AU7453501A (en) * 2000-06-15 2001-12-24 Taisho Pharmaceutical Co Ltd Hydroxyformamidine derivatives and medicines containing the same
JP2004512361A (ja) 2000-11-03 2004-04-22 エムシーダブリユー　リサーチ　フオンデーシヨン　インコーポレーテツド 脳血管疾患治療法としての２０−ｈｅｔｅ合成酵素阻害薬の使用
CN1272313C (zh) 2001-04-26 2006-08-30 大正制药株式会社 20－羟基二十碳四烯酸生成抑制剂
US6818662B2 (en) 2002-05-28 2004-11-16 Taisho Pharmaceutical Co., Ltd. Pharmaceutical composition
CN1293049C (zh) * 2002-09-12 2007-01-03 大正制药株式会社 N－羟基甲脒衍生物
JP2008230968A (ja) * 2005-06-30 2008-10-02 Taisho Pharmaceutical Co Ltd 脳梗塞治療用の医薬
US8846764B2 (en) 2006-09-13 2014-09-30 The Medical College Of Wisconsin, Inc. Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases
AU2018312680A1 (en) 2017-08-10 2020-03-19 Taisho Pharmaceutical Co., Ltd. Pyridine compound substituted with azole

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CH609024A5 (en) * 1974-09-30 1979-02-15 Lafon Labor Process for the preparation of new sulphur-containing diaryl and oxygen-containing diaryl compounds
DE2717437A1 (de) * 1977-04-20 1978-10-26 Hoechst Ag Substituierte n-phenylformamidoxime und verfahren zu ihrer herstellung
US4237168A (en) * 1979-06-11 1980-12-02 The Dow Chemical Company N-(4-Chloro-2-methylphenyl)-N-hydroxy methanimidamide and its pesticidal use
IT1209431B (it) * 1980-11-28 1989-07-16 Angeli Inst Spa Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.
AU3022984A (en) * 1983-07-15 1985-01-17 Nippon Soda Co., Ltd. Formamidoxime derivatives
JPS60132881A (ja) 1983-12-21 1985-07-15 三菱電機株式会社 油圧エレベ−タの制御装置
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
US6395781B1 (en) * 1998-02-26 2002-05-28 Mcw Research Foundation 20-HETE antagonists and agonists

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HK1050141A1 (en) 2003-06-13
CN1250209C (zh) 2006-04-12
US6864254B1 (en) 2005-03-08
DK1226819T3 (da) 2006-05-22
EP1226819A4 (de) 2003-06-04
AU759604B2 (en) 2003-04-17
AU1053301A (en) 2001-05-14
CY1105591T1 (el) 2010-07-28
KR100767508B1 (ko) 2007-10-17
ES2256053T3 (es) 2006-07-16
CA2389378C (en) 2009-11-24
US20040110830A1 (en) 2004-06-10
EP1226819A1 (de) 2002-07-31
EP1226819B1 (de) 2006-01-18
US7078400B2 (en) 2006-07-18
CN1382045A (zh) 2002-11-27
DE60025644T2 (de) 2006-09-07
JP4045099B2 (ja) 2008-02-13
WO2001032164A1 (fr) 2001-05-10
KR100785148B1 (ko) 2007-12-11
KR20020050248A (ko) 2002-06-26
ATE315932T1 (de) 2006-02-15
CA2389378A1 (en) 2001-05-10
DE60025644T8 (de) 2007-03-29

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Inventor name: SATO, MASAKAZU, TAISHO PHARMACEUTICAL CO., LTD., T

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