DK1780197T3 - 5-Substituerede 2-phenylamino-benzamider som MEK-inhibitorer - Google Patents

5-Substituerede 2-phenylamino-benzamider som MEK-inhibitorer

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Publication number
DK1780197T3
DK1780197T3 DK05767184.4T DK05767184T DK1780197T3 DK 1780197 T3 DK1780197 T3 DK 1780197T3 DK 05767184 T DK05767184 T DK 05767184T DK 1780197 T3 DK1780197 T3 DK 1780197T3
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DK
Denmark
Prior art keywords
benzamides
phenylamino
substituted
mek inhibitors
present
Prior art date
Application number
DK05767184.4T
Other languages
English (en)
Inventor
Yoshiaki Isshiki
Yasunori Kohchi
Eisaku Mizuguchi
Hitoshi Iikura
Yasuaki Matsubara
Shinji Tsujii
Nobuo Shimma
Masanori Miwa
Satoshi Aida
Masami Kohchi
Takeshi Murata
Kosuke Aso
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DK1780197T3 publication Critical patent/DK1780197T3/da

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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
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    • C07D263/18—Oxygen atoms
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
DK05767184.4T 2004-07-26 2005-07-26 5-Substituerede 2-phenylamino-benzamider som MEK-inhibitorer DK1780197T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004218004 2004-07-26
JP2005072093 2005-03-14
PCT/JP2005/013620 WO2006011466A1 (ja) 2004-07-26 2005-07-26 Mek阻害物質としての５－置換－２－フェニルアミノ－ベンズアミド類

Publications (1)

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DK1780197T3 true DK1780197T3 (da) 2011-01-31

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DK05767184.4T DK1780197T3 (da) 2004-07-26 2005-07-26 5-Substituerede 2-phenylamino-benzamider som MEK-inhibitorer

Country Status (27)

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US (2) US7745663B2 (da)
EP (1) EP1780197B9 (da)
JP (1) JP4090070B2 (da)
KR (1) KR101153556B1 (da)
CN (1) CN101124199B (da)
AT (1) ATE485265T1 (da)
AU (1) AU2005265769B2 (da)
BR (1) BRPI0513750A (da)
CA (1) CA2575232C (da)
CY (1) CY1110969T1 (da)
DE (1) DE602005024279D1 (da)
DK (1) DK1780197T3 (da)
ES (1) ES2354822T3 (da)
HK (1) HK1116766A1 (da)
HR (1) HRP20110006T1 (da)
IL (1) IL179634A (da)
MX (1) MX2007000736A (da)
MY (1) MY144232A (da)
NO (1) NO20071042L (da)
NZ (1) NZ551812A (da)
PL (1) PL1780197T3 (da)
PT (1) PT1780197E (da)
RS (1) RS51783B (da)
SG (2) SG151260A1 (da)
SI (1) SI1780197T1 (da)
TW (1) TWI361066B (da)
WO (1) WO2006011466A1 (da)

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WO2006011466A1 (ja) 2006-02-02
CN101124199B (zh) 2011-12-14
EP1780197B1 (en) 2010-10-20
EP1780197B9 (en) 2011-04-06
PT1780197E (pt) 2010-12-17
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CA2575232A1 (en) 2006-02-02
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