DE60025644T8 - Hemmer für das 20-hete-produzierende enzym - Google Patents

Hemmer für das 20-hete-produzierende enzym Download PDF

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Publication number
DE60025644T8
DE60025644T8 DE60025644T DE60025644T DE60025644T8 DE 60025644 T8 DE60025644 T8 DE 60025644T8 DE 60025644 T DE60025644 T DE 60025644T DE 60025644 T DE60025644 T DE 60025644T DE 60025644 T8 DE60025644 T8 DE 60025644T8
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present
hemmer
hete
producing enzyme
pharmaceutically
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DE60025644T
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DE60025644T2 (de
DE60025644D1 (de
Inventor
Masakazu Taisho Pharmaceutical Co. Ltd. Sato
Noriyuki Taisho Pharmaceutical Co. Ltd. MIYATA
Takaaki Taisho Pharmaceutical Co. Ltd. ISHII
Yuko Taisho Pharmaceutical Co. Ltd. KOBAYASHI
Hideaki Taisho Pharmaceutical Co. Ltd. AMADA
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Taisho Pharmaceutical Co Ltd
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Taisho Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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DE60025644T 1999-11-01 2000-11-01 Hemmer für das 20-hete-produzierende enzym Active DE60025644T8 (de)

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JP31113799 1999-11-01
JP31113799 1999-11-01
JP37234799 1999-12-28
JP37234799 1999-12-28
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JP2000180478 2000-06-15
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JP2000180476 2000-06-15
JP2000180473 2000-06-15
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AU7453501A (en) * 2000-06-15 2001-12-24 Taisho Pharmaceutical Co Ltd Hydroxyformamidine derivatives and medicines containing the same
EP1330240A2 (de) * 2000-11-03 2003-07-30 MCW Research Foundation Verwendung von inhibitoren der 20-hete bildenden enzymen als therapie für zerebrovasculäre erkrankungen
US7214714B2 (en) 2001-04-26 2007-05-08 Taisho Pharmaceutical Co. Ltd. 20-hydroxyeicosatetraenoic acid production inhibitors
US6818662B2 (en) 2002-05-28 2004-11-16 Taisho Pharmaceutical Co., Ltd. Pharmaceutical composition
US7288566B2 (en) 2002-09-12 2007-10-30 Taisho Pharmaceutical Co., Ltd. N-hydroxyformamidine derivatives
JP2008230968A (ja) * 2005-06-30 2008-10-02 Taisho Pharmaceutical Co Ltd 脳梗塞治療用の医薬
WO2008034011A2 (en) 2006-09-13 2008-03-20 Mcw Research Foundation, Inc. Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases
KR20200038457A (ko) 2017-08-10 2020-04-13 다이쇼 세이야꾸 가부시끼가이샤 아졸로 치환된 피리딘 화합물

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CH609024A5 (en) * 1974-09-30 1979-02-15 Lafon Labor Process for the preparation of new sulphur-containing diaryl and oxygen-containing diaryl compounds
DE2717437A1 (de) 1977-04-20 1978-10-26 Hoechst Ag Substituierte n-phenylformamidoxime und verfahren zu ihrer herstellung
US4237168A (en) * 1979-06-11 1980-12-02 The Dow Chemical Company N-(4-Chloro-2-methylphenyl)-N-hydroxy methanimidamide and its pesticidal use
IT1209431B (it) * 1980-11-28 1989-07-16 Angeli Inst Spa Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.
AU3022984A (en) * 1983-07-15 1985-01-17 Nippon Soda Co., Ltd. Formamidoxime derivatives
JPS60132881A (ja) 1983-12-21 1985-07-15 三菱電機株式会社 油圧エレベ−タの制御装置
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
US6395781B1 (en) * 1998-02-26 2002-05-28 Mcw Research Foundation 20-HETE antagonists and agonists

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JP4045099B2 (ja) 2008-02-13
WO2001032164A1 (fr) 2001-05-10
EP1226819A4 (de) 2003-06-04
US6864254B1 (en) 2005-03-08
DK1226819T3 (da) 2006-05-22
CY1105591T1 (el) 2010-07-28
DE60025644T2 (de) 2006-09-07
US7078400B2 (en) 2006-07-18
AU1053301A (en) 2001-05-14
HK1050141A1 (en) 2003-06-13
KR100785148B1 (ko) 2007-12-11
EP1226819A1 (de) 2002-07-31
ES2256053T3 (es) 2006-07-16
EP1226819B1 (de) 2006-01-18
KR20020050248A (ko) 2002-06-26
CN1250209C (zh) 2006-04-12
KR100767508B1 (ko) 2007-10-17
KR20070087044A (ko) 2007-08-27
CA2389378C (en) 2009-11-24
DE60025644D1 (de) 2006-04-06
CN1382045A (zh) 2002-11-27
ATE315932T1 (de) 2006-02-15
CA2389378A1 (en) 2001-05-10
AU759604B2 (en) 2003-04-17

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Inventor name: SATO, MASAKAZU, TAISHO PHARMACEUTICAL CO., LTD., T

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Inventor name: ISHII, TAKAAKI, TAISHO PHARMACEUTICAL CO., LTD., T

Inventor name: KOBAYASHI, YUKO, TAISHO PHARMACEUTICAL CO., LTD.,

Inventor name: AMADA, HIDEAKI, TAISHO PHARMACEUTICAL CO., LTD., T