YU83602A - Derivati fenilglicina - Google Patents

Derivati fenilglicina

Info

Publication number
YU83602A
YU83602A YU83602A YUP83602A YU83602A YU 83602 A YU83602 A YU 83602A YU 83602 A YU83602 A YU 83602A YU P83602 A YUP83602 A YU P83602A YU 83602 A YU83602 A YU 83602A
Authority
YU
Yugoslavia
Prior art keywords
phenylglycine derivatives
physiologically acceptable
derivatives
phenylglycine
carbamimidoyl
Prior art date
Application number
YU83602A
Other languages
English (en)
Inventor
Leo Alig
Zbinden Katrin Groebke
Kurt Hilpert
Holger Kuehne
Ulrike Obst
Hans Peter Wessel
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU83602A publication Critical patent/YU83602A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Pronalazak se odnosi na nove N-(4-karbamimidoil-fenil)-glicin derivate formule (I), naznačene time što X i R1 do R5 imaju značenje dato u opisu i zahtevima pronalaska, kao i na vodene rastvore i rastvore i/ili na njihove fiziološki prihvatljive soli i/ili na njihove fiziološki prihvatljive estre.[The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula (I) wherein X and R1 to R5 are as defined in the description and in the claims, as well as hydrates or solvates and/or physiologically acceptable salts thereof and/or physiologically acceptable esters thereof.
YU83602A 2000-05-23 2001-05-17 Derivati fenilglicina YU83602A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00110881 2000-05-23

Publications (1)

Publication Number Publication Date
YU83602A true YU83602A (sh) 2006-05-25

Family

ID=8168800

Family Applications (1)

Application Number Title Priority Date Filing Date
YU83602A YU83602A (sh) 2000-05-23 2001-05-17 Derivati fenilglicina

Country Status (23)

Country Link
US (1) US6548694B2 (sh)
EP (1) EP1289939A1 (sh)
JP (1) JP3842132B2 (sh)
KR (1) KR100569517B1 (sh)
CN (1) CN1305839C (sh)
AR (1) AR028596A1 (sh)
AU (2) AU8177401A (sh)
BR (1) BR0110998A (sh)
CA (1) CA2408602C (sh)
EC (1) ECSP024360A (sh)
HU (1) HUP0302073A2 (sh)
IL (1) IL152581A0 (sh)
MA (1) MA26905A1 (sh)
MX (1) MXPA02011466A (sh)
NO (1) NO20025590D0 (sh)
NZ (1) NZ522412A (sh)
PE (1) PE20011314A1 (sh)
PL (1) PL361355A1 (sh)
RU (1) RU2268257C2 (sh)
UY (1) UY26721A1 (sh)
WO (1) WO2001090051A1 (sh)
YU (1) YU83602A (sh)
ZA (1) ZA200208899B (sh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101744T2 (tr) * 1998-12-14 2001-12-21 F. Hoffmann-La Roche Ag Fenilglisin türevleri.
DE10300049A1 (de) * 2003-01-03 2004-07-15 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Faktor VIIa inhibieren
US6642386B2 (en) 2002-02-06 2003-11-04 Hoffmann-La Roche Inc. N-(4-carbamimidoyl-phenyl)-glycine derivatives
GB0211931D0 (en) * 2002-05-23 2002-07-03 Univ Liverpool Methods & device utilizing adsorption of molecules at a surface or interface
TW200410921A (en) * 2002-11-25 2004-07-01 Hoffmann La Roche Mandelic acid derivatives
EP1594505A4 (en) 2003-02-11 2008-08-13 Bristol Myers Squibb Co PHENYLGLYCIN DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS
JP2006517589A (ja) 2003-02-11 2006-07-27 ブリストル−マイヤーズ　スクイブ　カンパニー セリンプロテアーゼ・インヒビターとして有用なベンゼンアセトアミド化合物
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
US7917130B1 (en) 2003-03-21 2011-03-29 Stratosaudio, Inc. Broadcast response method and system
US7776804B2 (en) * 2005-03-16 2010-08-17 The Lubrizol Corporation Viscosity improver compositions providing improved low temperature characteristics to lubricating oil
US7056932B2 (en) 2003-12-19 2006-06-06 Hoffman-La Roche Inc. Heterocyclyl substituted 1-alkoxy acetic acid amides
WO2006041119A1 (ja) * 2004-10-13 2006-04-20 Eisai R & D Management Co., Ltd. ヒドラジド誘導体
WO2006045010A2 (en) * 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
PE20061117A1 (es) 2005-01-10 2006-10-13 Bristol Myers Squibb Co DERIVADOS DE FENILGLICINAMIDA COMO INHIBIDORES DEL FACTOR VIIa
ATE455103T1 (de) * 2005-06-24 2010-01-15 Bristol Myers Squibb Co Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate
WO2007103996A1 (en) * 2006-03-09 2007-09-13 Bristol-Myers Squibb Company 2-(aryloxy)acetamide factor viia inhibitors useful as anticoagulants
JP5016592B2 (ja) * 2006-03-24 2012-09-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 トリアゾロン誘導体
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
DK2118074T3 (en) 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
EP1967522A1 (en) * 2007-03-07 2008-09-10 Novo Nordisk A/S New blood coagulation factor inhibitors
JPWO2009038157A1 (ja) * 2007-09-21 2011-01-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 ２，３−ジヒドロ−イミノイソインドール誘導体
WO2009079417A1 (en) 2007-12-14 2009-06-25 Stratosaudio, Inc. Systems and methods for scheduling interactive media and events
RU2520098C2 (ru) * 2008-06-26 2014-06-20 Ресверлоджикс Корп. Способы получения производных хиназолинона
JP5635535B2 (ja) 2009-01-08 2014-12-03 レスバーロジックス コーポレイション 心血管疾患の予防および治療のための化合物
CA2992231C (en) 2009-03-18 2022-03-29 Resverlogix Corp. Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents
KR20190091564A (ko) 2009-04-22 2019-08-06 리스버로직스 코퍼레이션 신규한 소염제
CN102887836B (zh) * 2011-07-18 2014-03-26 西南大学 L-苯甘氨酸衍生物及其应用
CN103945848B (zh) 2011-11-01 2016-09-07 雷斯韦洛吉克斯公司 被取代的喹唑啉酮的口服即释制剂
GB201118876D0 (en) * 2011-11-01 2011-12-14 Astex Therapeutics Ltd Pharmaceutical compounds
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
CA2895905A1 (en) 2012-12-21 2014-06-26 Zenith Epigenetics Corp. Novel heterocyclic compounds as bromodomain inhibitors
KR102662814B1 (ko) 2015-03-13 2024-05-03 리스버로직스 코퍼레이션 보체 관련 질환을 치료하기 위한 조성물 및 치료 방법
CN111072562B (zh) * 2019-11-07 2021-12-07 中山大学 一种四氢异喹啉衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE243192T1 (de) 1997-12-04 2003-07-15 Hoffmann La Roche N-(4-carbamimido-phenyl)-glycinamidderivate
WO1999041231A1 (fr) * 1998-02-17 1999-08-19 Ono Pharmaceutical Co., Ltd. Derives amidino utilises comme ingredients actifs et medicaments les contenant
TR200101744T2 (tr) * 1998-12-14 2001-12-21 F. Hoffmann-La Roche Ag Fenilglisin türevleri.

Also Published As

Publication number Publication date
AU8177401A (en) 2001-12-03
AR028596A1 (es) 2003-05-14
CA2408602A1 (en) 2001-11-29
IL152581A0 (en) 2003-05-29
KR100569517B1 (ko) 2006-04-07
MXPA02011466A (es) 2003-04-25
EP1289939A1 (en) 2003-03-12
UY26721A1 (es) 2001-12-28
AU2001281774B2 (en) 2005-03-10
US6548694B2 (en) 2003-04-15
KR20030007678A (ko) 2003-01-23
NZ522412A (en) 2004-05-28
NO20025590L (no) 2002-11-21
JP3842132B2 (ja) 2006-11-08
HUP0302073A2 (hu) 2003-09-29
MA26905A1 (fr) 2004-12-20
CA2408602C (en) 2008-01-08
NO20025590D0 (no) 2002-11-21
WO2001090051A1 (en) 2001-11-29
RU2268257C2 (ru) 2006-01-20
PE20011314A1 (es) 2002-01-04
ZA200208899B (en) 2004-02-19
CN1305839C (zh) 2007-03-21
JP2003534311A (ja) 2003-11-18
BR0110998A (pt) 2003-04-08
ECSP024360A (es) 2003-03-31
CN1430599A (zh) 2003-07-16
PL361355A1 (en) 2004-10-04
US20020004608A1 (en) 2002-01-10

Similar Documents

Publication Publication Date Title
YU83602A (sh) Derivati fenilglicina
YU41801A (sh) Derivati fenilglicina
BG106013A (en) New compounds and compositions as protease inhibitors
BE2017C018I2 (sh)
AP2002002637A0 (en) Novel piperazine
DK1204654T3 (da) Benzofurylpiperaziner og benzofurylhomopiperaziner: Serotonin agonister
EA200200510A1 (ru) 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
HK1045990A1 (en) Novel derivatives and analogues of galanthamin.
ZA200404752B (en) 6-aminomorphinane derivatives method for the production and use thereof
MY133969A (en) Indoloquinazolinones
MXPA03009548A (es) Arilsulfonamidas como agentes antivirales.
SI1086096T1 (en) Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
YU30603A (sh) Derivati premošćenog piperazina
MXPA05009282A (es) Derivados de anilina sustituidos.
SE9903290D0 (sv) Novel compounds
PT1204659E (pt) Benzofuranos serotoninergicos
SI1377574T1 (sh)
MY136938A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
MXPA03003971A (es) Derivados de indol como inhibidores de pde5.
MXPA03008248A (es) Agentes colorantes para fibras de queratina que contienen derivados de n-heteroarilmetil-m-fenilendiamina, asi como nuevos derivados de n-heteroarilmetil-m-fenilendiamina.
SG171472A1 (en) Substituted aniline derivatives
MXPA02001406A (es) Heterociclilos-2h-cromenos substituidos.
AP2002002595A0 (en) Heterocyclic amide derivatives.
MY136638A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts